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Intravascular contrast agents in diagnostic applications： Use of red blood cells to improve the lifespan and efficacy of blood pool contrast agents

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Nano Research 2017年第3期10卷 731-766页

作者： Antonella Antonelli Carla Sfara Mauro Magnani Department of Biomolecular Sciences Biochemistry and Molecular Biology Section University of Urbino 'Carlo Bo' Via Saffi 2 61029Urbino (PU) Italy

In medicine, discrimination between pathologies and normal areas is of great importance, and in most cases, such discrimination is made possible by novel imaging technologies. Numerous modalities have been developed to visualize tissue vascularization in cardiovascular diseases or during angiogenic and vasculogenic processes. Here, we report the recent advances in vasculature imaging, providing an overview of the current non-invasive approaches in biomedical diagnostics and potential future strategies for prognostic assessment of vessel diseases, such as aneurysms and coronary artery occlusion leading to myocardial infarction. There are several contrast agents （CAs） available to improve the visibility of specific tissues at the early stage of diseases, allowing for rapid treatment. However, CAs are also hampered by numerous limitations, including rapid diffusion from blood vessels into the interstitial space, toxicity, and low sensitivity. Extravasation from blood vessels leads to a rapid loss of the image. If the contrast medium can fully be confined to the vascular space, high-resolution structural and functional vascular imaging could be obtained. Many scientists have contributed new materials and/or new carrier systems. For example, the use of red blood cells （RBCs） as CA-delivery systems appears to provide a scalable alternative to current procedures that allows adequate vascular imaging. Recognition and removal of CAs from the circulation can be prevented and/or delayed by using RBCs as biomimetic CA-carriers, and this technology should be clinically validated.

关键词： diagnostic applications magnetic resonanceimaging (MRI) vascular contrast agents red blood cells medical imaging new tomography

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Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

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Nano Research 2018年第4期11卷 2285-2294页

作者： Airui Jiang Bin Song Xiaoyuan Ji Fei Peng Houyu Wang Yuanyuan Su Yao He Laboratory of Nanoscale Biochemical Analysis Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhau Nano Science and Technology (NANO-CIC) Soochow University Suzhou 215123 China

Based on the unique advantages of fluorescent silicon nanoparticles （SiNPs）, long circulation red blood cells （RBCs）, and anti-cancer drug molecules （i.e., doxorubicin （DOX））, we developed multifunctional DOX-loaded SiNPs impregnated into RBCs. Importantly, the resulting drug delivery systems （DDSs） simultaneously exhibited bright fluorescence coupled with robust photostability （i.e., - 24% loss of fluorescent intensity after 25 min continuous laser irradiation） and significantly lengthened blood residency （i.e., t1/2 = 7.31 ± 0.96 h, 3.9-fold longer than pure DOX-loaded SiNPs）. Therefore, this novel DDS featuring multi-functionalities shows high potential for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in a synchronous manner.

关键词： fluorescent silicon nanoparticles mulfi-function red blood cells drug delivery system

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A DLM/FD/IB Method for Simulating Compound Cell Interacting with red blood cells in a Microchannel

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 535-552页

作者： Shihai ZHAO Yao YU Tsorng-Whay PAN Roland GLOWINSKI Department of Mathematics Dongbei University of Finance and EconomicsDalian 116023LiaoningChina CGG HoustonTX 77072USA Department of Mathematics University of HoustonHoustonTX 77204USA Department of Mathematics Hong Kong Baptist UniversityHong KongChina

In this article, a computational model and related methodologies have been tested for simulating the motion of a malaria infected red blood cell （iRBC for short） in Poiseuille flow at low Reynolds numbers. Besides the deformability of the red blood cell membrane, the migration of a neutrally buoyant particle （used to model the malaria parasite inside the membrane） is another factor to determine the iRBC motion. Typically an iRBC oscillates in a Poiseuille flow due to the competition between these two factors. The interaction of an iRBC and several RBCs in a narrow channel shows that, at lower flow speed, the iRBC can be easily pushed toward the wall and stay there to block the channel. But, at higher flow speed, RBCs and iRBC stay in the central region of the channel since their migrations axe dominated by the motion of the RBC membrane.

关键词： Compound cell red blood cells Elastic spring model Fictitious domainmethod Immersed boundary method Microchannel

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Cyclic arginine-glycine-aspartic acid-modified red blood cells for drug delivery:Synthesis and in vitro evaluation

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Journal of Pharmaceutical Analysis 2022年第2期12卷 324-331页

作者： Chen Wang Min Wang Yan Zhang Hongxin Jia Binbin Chen Department of Pharmaceutics School of PharmacyXiamen Medical CollegeXiamenFujian361023China Institute of Respiratory Diseases Xiamen Medical CollegeXiamenFujian361023China Department of Pharmaceutics School of PharmacyHarbin University of CommerceHarbin150076China Department of Pharmacy Xiamen Xianyue HospitalXiamenFujian361012China

red blood cells(RBCs)are an excellent choice for cell preparation research because of their biocompatibility,high drug loading,and long *** this study,doxorubicin(DOX)was encapsulated with RBCs as the *** biotin-avidin system binding principle was used to modify biotinylated cyclic arginine-glycine-aspartic acid(cRGD)onto RBC surfaces for accurate targeting,high drug loading,and sustained drug *** RBC drug delivery system(DDS)was characterized,and the concentration of surface sulfur in the energy spectrum was 6.330%.The physical and chemical properties of RBC DDS were as follows:drug content,0.857 mg/mL;particle size,3339 nm;potential value,12.5 mV;and cumulative release rate,81.35%.There was no significant change in RBC morphology for up to seven *** results of the targeting and cytotoxicity studies of RBC DDS showed that many RBCs covered the surfaces of U251 cells,and the fluorescence intensity was higher than that of MCF-7 *** IC50 value of unmodified drug-loaded RBCs was 2.5 times higher than that of targeted modified drug-loaded RBCs,indicating that the targeting of cancer cells produced satisfactory *** study confirms that the RBC DDS has the characteristics of accurate targeting,high drug loading,and slow drug release,which increases its likelihood of becoming a clinical cancer treatment in the future.

关键词： Cytotoxicity red blood cells Drug delivery Targeting

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Toxic effects of Litsea elliptica Blume essential oil on red blood cells of Sprague-Dawley rats

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第11期10卷 813-819页

作者： Izatus Shima TAIB Siti Balkis BUDIN Seri Maseran SITI NOR AIN Jamaludin MOHAMED Santhana Raj LOUIS Srijit DAS Sulaiman SALLEHUDIN Nor Fadilah RAJAB Othman HIDAYATULFATHI Department of Biomedical Sciences Faculty of Allied Health SciencesUniversiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia Unit of Electron Microscope Institute for Medical ResearchJalan Pahang50588 Kuala LumpurMalaysia Department of Anatomy Universiti Kebangsaan MalaysiaJalan Raja Muda Abdul Aziz50300 Kuala LumpurMalaysia

Litsea elliptica Blume leaves have been traditionally used as medicinal herbs because of its antimutagenicity,chemopreventative and insecticidal properties. In this study,the toxic effects of L. elliptica essential oil against Sprague-Dawley rat’s red blood cells (RBCs) were evaluated. L. elliptica essential oil was given by oral gavage 5 times per week for 3 treated groups in the doses of 125,250,and 500 mg/(kg body weight),respectively,and the control group received distilled water. Full blood count,RBC osmotic fragility,RBC morphological changes,and RBC membrane lipid were analyzed 28 d after the treatment. Although L. elliptica essential oil administration had significantly different effects on hemoglobin (Hb),mean cell hemoglobin concentration (MCHC),mean cell volume (MCV),and mean cell hemoglobin (MCH) in the experimental groups as compared to the control group (P0.05). It is concluded that structural changes in the RBC membrane due to L. elliptica essential oil administration did not cause severe membrane damage.

关键词： Litsea elliptica Toxicity red blood cells Morphology Cell membrane Echinocyte

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Exact Singularity Subtraction from Boundary Integral Equations in Modeling Vesicles and red blood cells

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Numerical Mathematics(Theory,Methods and Applications) 2014年第4期7卷 413-434页

作者： Alexander Farutin Chaouqi Misbah UniversitéGrenoble I/CNRS Laboratoire Interdisciplinaire de Physique/UMR5588Grenoble F-38041France

The study of vesicles,capsules and red blood cells(RBCs)under flow is a field of active research,belonging to the general problematic of fluid/structure ***,we are interested in modeling vesicles,capsules and RBCs using a boundary integral formulation,and focus on exact singularity subtractions of the kernel of the integral equations in *** order to increase the precision of singular and near-singular integration,we propose here a refinement procedure in the vicinity of the pole of the Green-Oseen *** refinement is performed homogeneously everywhere on the source surface in order to reuse the additional quadrature nodes when calculating boundary integrals in multiple target *** also introduce a multi-level look-up algorithm in order to select the additional quadrature nodes in vicinity of the pole of the Green-Oseen *** expected convergence rate of the proposed algorithm is of order δ(1/N^(2))while the computational complexity is of order δ(N^(2) lnN),where N is the number of degrees of freedom used for surface *** numerical tests are presented to demonstrate the convergence and the efficiency of the method.

关键词： Stokes flow fluid structure interaction boundary integral method red blood cells singularity subtraction

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From stem cells to red blood cells:how far away from the clinical application?

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Science China(Life Sciences) 2014年第6期57卷 581-585页

作者： XIE XiaoYan LI YanHua PEI XueTao Stem Cell and Regenerative Medicine Lab Beijing Institute of Transfusion Medicine South China Research Center for Stem Cell and Regenerative Medicine

The generation of red blood cells(RBCs)from stem cells provides a solution for deficiencies in blood ***,primary hematopoietic stem cells,embryonic stem cells and induced pluripotent stem cells have shown the potential to produce fully mature ***,we discuss the advantages,induction protocols,progress and possible clinical applications of stem cells in RBC production.

关键词： stem cells red blood cells differentiation clinical application

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Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 23-31页

作者： Petr Ermolinskiy Matvey Maksimov Andrei Lugovtsov Alexey Muravyov Irina Tikhomirova Alexander Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University Moscow 119991Russia Faculty of Physical Education K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia Faculty of Natural Sciences K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia

red blood cell(RBC)aggregation as well as their deformation significantly affects blood *** processes depend on various factors,one of which is concentration of the nitric oxide,one of the main signaling molecule in the *** purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells(RBCs)in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in *** properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,*** study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100,and 200M,while EDTA-stabilized blood showed slightly decreased aggregation and unchanged *** washed RBCs in dextran solution,the addition of sodium nitroprusside(in the concentrations of 100,and 200M)resulted in decreased aggregation and increased ***-ndings aid in our understanding of nitric oxide's effect on RBC microrheological properties.

关键词： Sodium nitroprusside nitric oxide red blood cells RBC aggregation diffuse light scattering laser diffractometer

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Using Optical Tweezers to Study the Friction of the red blood cells

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Advances in Bioscience and Biotechnology 2024年第2期15卷 100-111页

作者： Edoukoua Jean Michel Konin Pavel Yale Abadê Ange-Boris N’guessan Kouassi Benoit Kouakou Abaka Michel Kouacou Eugene Megnassan Département des Sciences et Techniques Université Alassane Ouattara Bouaké C&#244te d’Ivoire Laboratoire d’Instrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Félix Houphou&#235t-Boigny (INPHB) Yamoussoukro C&#244te d’Ivoire Classes préparatoires aux grandes Ecoles Université de San Pedro San Pedro C&#244te d’Ivoire Laboratoire de Physique Fondamentale et Appliquée Université Nangui Abrogoua (UNA) Abidjan C&#244te d’Ivoire

In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB).

关键词： Friction Indentation Optical Tweezers Tribology red blood cells

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Water Efflux in red blood cells of Sickle Cell Patients under Spontaneous Deoxygenation

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Journal of Biosciences and Medicines 2016年第12期4卷 152-161页

作者： Manuel Arsenio Lores Guevara Yulianela Mengana Torres Juan Carlos García Naranjo Andrés Ramírez Aguilera Lidia Clara Suárez Beyrio María Altagracia Marichal Felue Teresa Simón Brada Jan Philippé Centro de Biofí sica Mé dica Santiago de Cuba Cuba Hospital General “Juan Bruno Zayas Alfonso” Santiago de Cuba Cuba Department of Clinical Chemistry Immunology and Microbiology Ghent University Ghent Belgium

The water transport through red blood cells (RBC) membrane has been previously studied in Sickle Cell Disease (SCD) using oxygenated RBC or under complete deoxygenation. In this work, the water efflux in RBC of sickle cell patients was studied under spontaneous deoxygenation conditions. With that purpose, a magnetic resonance method was used to evaluate the water exchange time (τe) and the permeability through the erythrocyte membrane (P) measuring the spin-spin relaxation time (T2) in doped and non-doped RBC. Carr-Purcell-Meiboon-Gill (CPMG) pulse sequence was used to measure T2 in a magnetic resonance console coupled to one homogeneous magnet system (0.095 T). An increase of the water transport in RBC from sickle cell patients was observed and characterized with a τe value of 15.2 ± 0.8 ms. The abnormal activation of the Psickle, Gardos, and potassium chloride cotransporter channels starting from deoxygenation, as well as, the possible appearance of new pores due to the increase of the hemoglobin-membrane interaction, are suggested to explain this abnormal transport phenotype. The change of the water volume to surface ratio (V/S) in the sickle cells is also suggested to be considered in P calculation under deoxygenation. The results obtained in this work increase the fundamental knowledge about molecular mechanism involved in SCD and could be useful in the development of new methods for diagnostic and treatment evaluation.

关键词： red blood cells Water Permeability Nuclear Magnetic Relaxation Sickle Cell Disease

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