检索结果-南通市图书馆

Material basis for inhibition of Dragon's Blood on evoked discharges of wide dynamic range neurons in spinal dorsal horn of rats

在线全文

学校读者我要写书评

暂无评论

引用

Science China(Life Sciences) 2008年第11期51卷 1025-1038页

作者： GUO Min, CHEN Su & LIU XiangMing Department of Biological & Medical Engineering, South-Central University for Nationalities, Wuhan 430074, China 1. Department of Biological & Medical Engineering South-Central University for Nationalities Wuhan 430074 China

In vivo experiments were designed to verify the analgesic effect of Dragon’s Blood and the material basis for this effect. Extracellular microelectrode recordings were used to observe the effects of Dragon’s Blood and various combinations of the three components (cochinchinenin A, cochinchinenin B, and loureirin B) extracted from Dragon’s Blood on the discharge activities of wide dynamic range (WDR) neurons in spinal dorsal horn (SDH) of intact male Wistar rats evoked by electric stimulation at sciatic nerve. When the Hill's coefficients describing the dose-response relations of drugs were dif-ferent, based on the concept of dose equivalence, the equations of additivity surfaces which can be applied to assess the interaction between three drugs were derived. Adopting the equations and Tal-larida's isobole equations used to assess the interaction between two drugs with dissimilar dose-response relations, the effects produced by various combinations of the three components in modulating the evoked discharge activities of WDR neurons were evaluated. Results showed that Dragon’s Blood and its three components could inhibit the evoked discharge frequencies of WDR neurons in a concentration-dependent way. The Hill's coefficients describing dose-response relations of three components were different. Only the combined effect of cochinchinenin A, cochinchinenin B and loureirin B was similar to that of Dragons Blood. Furthermore, the combined effect was synergistic. This investigation demonstrated that through the synergistic interaction of the three components Dragon’s Blood could interfere with the transmission and processing of pain signals in spinal dorsal horn. All these further proved that the combination of cochinchinenin A, cochinchinenin B, and loureirin B was the material basis for the analgesic effect of Dragon’s Blood.

关键词： Dragon’s Blood material basis for the efficacy extracellular microelectrode recordings wide dynamic range neurons interaction between drugs

Source complexity of the 2016 M_W7.8 Kaikoura (New Zealand) earthquake revealed from teleseismic and InSAR data

在线全文

学校读者我要写书评

暂无评论

引用

Earth and Planetary Physics 2018年第4期2卷 310-326页

作者： HaiLin Du Xu Zhang LiSheng Xu WanPeng Feng Lei Yi Peng Li Institute of Geophysics China Earthquake Administration Canada Center for Mapping and Earth Observation Natural Resources Canada School of Geodesy and Geomatics Wuhan University College of Marine Geosciences Ocean University of China

On November 13, 2016, an MW7.8 earthquake struck Kaikoura in South Island of New Zealand. By means of back-projection of array recordings, ASTFs-analysis of global seismic recordings, and joint inversion of global seismic data and co-seismic In SAR data, we investigated complexity of the earthquake source. The result shows that the 2016 MW7.8 Kaikoura earthquake ruptured about 100 s unilaterally from south to northeast(~N28°–33°E), producing a rupture area about 160 km long and about 50 km wide and releasing scalar moment 1.01×1021 Nm. In particular, the rupture area consisted of two slip asperities, with one close to the initial rupture point having a maximal slip value ~6.9 m while the other far away in the northeast having a maximal slip value ~9.3 m. The first asperity slipped for about 65 s and the second one started 40 s after the first one had initiated. The two slipped simultaneously for about 25 ***, the first had a nearly thrust slip while the second had both thrust and strike slip. It is interesting that the rupture velocity was not constant, and the whole process may be divided into 5 stages in which the velocities were estimated to be 1.4 km/s, 0 km/s, 2.1 km/s, 0 km/s and 1.1 km/s, respectively. The high-frequency sources distributed nearly along the lower edge of the rupture area, the highfrequency radiating mainly occurred at launching of the asperities, and it seemed that no high-frequency energy was radiated when the rupturing was going to stop.

关键词： 2016 MW7.8 Kaikoura earthquake back-projection of array recordings ASTFs-analysis of global recordings joint inversion of teleseismic and InSAR data complexity of source

PROJECTION LINKAGE BETWEEN HEGU ACUPOINT AND STN

在线全文

学校读者我要写书评

暂无评论

引用

World Journal of Acupuncture-Moxibustion 1998年第1期8卷 33-36页

作者：孟卓吕国蔚

Alternative stimulation of both the solitary tract nucleus (STN) and Hegu (HG) acupoint were made on the sodium pentobarbital anesthetized rats. The intracellular microelectrode recordings from the spinal drosal horn of C5 - T1 segments were used to search and identify the spinal neurons. A total of 53 neurons responding to the stimulation of both STN and HG was recorded intracellularly. 24 and 29 of them were found to antidromically and synaptically respond to the stimulation of STN, respectively. These neurons were mainly distributed in the laminae III - Vl of spinal dorsal horn. The results indicate that (i) some spinal neurons can receive somatic afferent inputs from HG and convey them to the visceral sensory nucleus - STN; (ii) the other spinal neurons receive afferent impulse from both the STN and HG; (iii) the convergence and integration between somatic and visceral sensory inputs might occur in these spinal neurons and STN.

关键词： Solitary tract nucleus Hegu point Spinal projection neurons Intracellular recordings