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Wide-spread neuropathic pain behavior in mice following unilateral infraorbital neurectomy is determined genetically and is sexually dimorphic

Wide-spread neuropathic pain behavior in mice following unil...

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中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Ze’ev SELTZER Barry J.SESSLE James HU University of Toronto Centre for the Study of Pain TorontoOntarioM5G1G6Canada

＜正＞Neuropathic pain following nerve injury in humans may spread to areas far beyond the territory of the injured nerve（"Extraterritorial pain"） and contralaterally（"Mirror image pain"）,and in extreme cases occupy large body parts. Certain trigeminal pain syndromes are more prevalent in women than *** aims of this study are 1) to produce a model of trigeminal neuropathic pain in mice of the A/J,C57BL/6J（’B6’） and DBA/2J inbred strains;2) to compare the pain spread in this model in male and female mice,in order to recommend the recombinant inbred（RI） mice lines,which provide a powerful assay to identify Quantitative Trait Loci（QTLs） for chronic pain *** hundred and twenty adult male and female mice of A/J,DBA/2J,B6 strains were divided into 12 groups（n = 10 mice per strain,gender,sham and nerve- injury groups）.The tactile allodynia-like behavior was determined as the average response score to 3 separate poking trials with a stiff Von Frey hair applied to the ears,the plantar surface of the forepaws and hindpaws bilaterally,and the middle part of the tail on days -8 and -2（preoperatively）,and days 1,3,8,13 and 20 postoperatively（TO’）.Heat hyperlagesia was determined from the frequency of withdrawal responses to 5 noxious heat stimuli delivered from an infrared diode laser to the same loci as the tactile allodynia test except for the forepaws on days -10 and -3（preoperatively）,and days 7,14,21,35 and 49 *** males,we found that unilateral ION-X produced significant tactile allodynia in the contralateral ear of A/J *** tactile allodynia was found in other loci of them and in any loci in other ***-X did not produce significant heat hyperalgesia in any tested loci of all three mice ***,heat hyperalgesia was demonstrated in the contralateral ear of female A/J mice and in the tail of female A/J and DBA/2J mice,on d 14 and d 21 *** transection of the infra-orbital nerve produces in mice tactile allodynia and heat hyper

关键词： wide-spread neuropathic pain infraorbital neurectomy recombinant inbred mice quantitative trait loci trigeminal neuropathy

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