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Thrombolytic efficacy of native recombinant staphylokinase on femoral artery thrombus of rabbits

Acta Pharmacologica Sinica 2007年第1期28卷 58-65页

作者： Chun-jian LI~1 Jun HUANG Zhi-jian YANG Ke-jiang CAO Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China DepartmentofCardiology theFirstAffiliatedHospitalofNanjingMedicalUniversityNanjing210029China

Aim:To investigate the thrombolytic efficacy,ideal dosage and administration ofnative recombinant staphylokinase(r-SAK).Methods:Forty New Zealand rab-bits were randomly assigned into the control,r-SAK low-dose,medial-dose,high-dose,single bolus,allied therapy,recombinant streptokinase(r-SK)and uroki-nase(UK)*** right femoral artery thrombosis models were made byballoon injury,and 120 min after the injury,the thrombolytic agents were infusedthrough the rabbits’ parallel-ear ***:(1)2 h after balloon injury,thepulse pressures of the right femoral arteries reduced to 0 or less than 10% of thatof left femoral arteries in all groups;(2)after thrombolytic therapy,the pulsepressures in some of the femoral arteries markedly enhanced to more than 50% ofthat of left femoral arteries;(3)the reopening rates in the r-SAK medial and high-dose groups were significantly higher than that of the *** reopening rateof the same dose native r-SAK was significant higher than that of UK and r-SK;(4)the patency score of the right femoral arteries tended to be better in the r-SAKmedial and high-dose groups than that of the low-dose group,and the time toreopening in the allied therapy group tended to be ***:(1)r-SAKhas a definite thrombolytic effect on the femoral artery thrombus of rabbits;(2)single bolus is an effective manner of r-SAK therapy,and r-SAK allied therapywith heparin may shorten the time to recanalization;(3)the efficacy of the samedose native r-SAK was superior to that of r-SK and UK.

关键词： recombinant staphylokinase recombinant streptokinase urokinase thrombolytic therapy

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