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Effects of GABAB receptors in the insula on recognition memory observed with behavioural test

Effects of GABAB receptors in the insula on recognition memo...

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中国神经科学学会第十二届全国学术会议

作者： Nan Wu Feng Wang Zhen Zhang Xi Yang Xiao-peng Zhao Xin-xiao Li Zhen-quan He Tao Sun Ningxia Key Laboratory of Cerebrocranial Disease Incubation Base of National Key Laboratory Ningxia Medical University Department of Neurosurgery General Hospital of Ningxia Medical University

Objective To compare the effects of intellicage and water maze test on effects of GABABR in insula on recognition memory of rats. Methods: Male Sprague-Dawley rats were randomly divided into control, sham, saline, baclofen（selective GABABR agonist） and CGP35348（GABABR antagonist） groups. Different testing procedures were employed using Intellicage and Morris water-maze test to detect changes in rat’s recognition memory. The expression of GABABR（GB1, GB2） in the insulars of rats was determined by immunofluorescence and Western Blotting at protein ***: the results of intellicage test showed that recognition of memory was impaired in position learning, punitive learning and punitive reversal learning by using baclofen and CGP 35348 compared with the control groups. In position reversal learning, there was no significant difference was found in the cognitive memory ability between the control groups with groups of CGP and baclofen. The results of Morris water-maze test showed that recognition of memory was impaired in the testing time. Data from immunofluorescence showed that GABABR（GB1, GB2） expression in the insular while the data of RT-PCR and Western blot showed that the relative expression of GB1 and GB2 was significantly increased in the baclofen group compared with the other control groups. The CGP35348 expression of GB1 and GB2 was significantly decreased. But there was no significant difference between the control groups. Conclusion（1） GABABR of insular plays an important role on the formation of recognition memory in rats.（2）Intellicage can add the lack of Morris water-maze test, and this behavioral system can provide more objective and accurate data.

关键词： GABABR insular recognition of memory intellicage water maze test

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