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A novel method for evaluating the dynamic biocompatibility of degradable biomaterials based on real-time cell analysis

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Regenerative Biomaterials 2020年第3期7卷 321-329页

作者： Xiaoxiao Gai Chenghu Liu Guowei Wang Yang Qin Chunguang Fan Jia Liu Yanping Shi Department of Biological Evaluation Shandong Quality Inspection Center for Medical DevicesNO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China Shandong Key Laboratory of Biological Evaluation for Medical Devices NO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China Department of Biological Evaluation NMPA Key Laboratory for Safety Evaluation of Biomaterials and Medical DevicesNO.15166 Century AvenueH-T Industrial Development ZoneJinan 250101China

Degradable biomaterials have emerged as a promising type of medical materials because of their unique advantages of biocompatibility,biodegradability and *** to their bioabsorbable and biocompatible properties,magnesium-based biomaterials are considered as ideal degradable medical ***,the rapid corrosion of magnesium-based materials not only limits their clinical application but also necessitates a more specific biological evaluation system and biosafety *** this study,extracts of pure Mg and its calcium alloy were prepared using different media based on ISO 10993:12;the Mg^2+ concentration and osmolality of each extract were *** biocompatibility was investigated using the MTT assay and xcelligence real-time cell analysis(RTCA).Cytotoxicity tests were conducted with L929,MG-63 and human umbilical vein endothelial cell *** results of the RTCA highly matched with those of the MTT assay and revealed the different dynamic modes of the cytotoxic process,which are related to the differences in the tested cell lines,Mg-based materials and dilution rates of *** study provides an insight on the biocompatibility of biodegradable materials from the perspective of cytotoxic dynamics and suggests the applicability of RTCA for the cytotoxic evaluation of degradable biomaterials.

关键词： degradable biomaterials biocompatibility real-time cell analysis magnesium-based biomaterials

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