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rapid testing methods for food contaminants and toxicants

Journal of Integrative Agriculture 2015年第11期14卷 2243-2264页

作者： Jiachi Chiou Arthur Ho Hon Leung Hang Wai Lee Wing-tak Wong Department of Applied Biology and Chemical Technology Food Safety and Technology Research CenterThe Hong Kong Polytechnic University Shenzhen Key Laboratory for Food Biological Safety Control Food Safety and Technology Research CentreThe Hong Kong Polytechnic University Shenzhen Research Institute

Food safety is one of the major concerns in every country regardless of the economic and social development. The frequent occurrence of food scandals in the world has led the Chinese government to implement several strategies to fortify the food supply system to a high food safety standard. This relies heavily on laboratory testing services but conventional methods for detection of food contaminants and toxicants are limited by sophisticated sample preparation procedures, long analysis time, large instruments and professional personnel to meet the increasing demands. In this review, we have incorporated most of the current and potential rapid detection methods for many notorious food contaminants and toxicants including microbial agents, toxic ions, pesticides, veterinary drugs and preservatives, as well as detection of genetically modified food genes and adulterated edible oil. Development of rapid, accurate, easy-to-use and affordable testing methods could urge food handlers and the public to actively screen for food contaminants and toxicants instead of passively relying on monitoring by the government examination facility. This review also provides several recommendations including how to encourage the public to engage in the food safety management system and provide optimal education and financial assistance that may improve the current Chinese food safety control system.

关键词： rapid testing food contaminants and toxins microbial agents pesticides veterinary drugs preservatives formaldehyde nitrite nitrate test strips

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Development of a rapid neutralizing antibody test for SARS-CoV-2 and its application for neutralizing antibody screening and vaccinated serum testing

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Infectious Medicine 2022年第2期1卷 95-102页

作者： Yuchang Li Mingyue Wang Hongzhen Wu Hui Zhao Lei Dong Yunfei Li Xiaofeng Li Ying Tang Sen Zhang Jing Li Chengfeng Qin Tao Jiang Yongqiang Deng Xiaoping Kang State Key Laboratory of Pathogen and Biosecurity The Academy of Military Medical Science Institute of Microbiology and EpidemiologyBeijingChina Beijing BGI-GBI Biotech Co. Ltd.BeijingChina Clinical Laboratory Department Air Force Medical CenterBeijingChina

Background:Since the outbreak of coronavirus disease(COVID-19),the high infection rate and mutation fre-quency of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent,have contributed to the ongoing global *** has become the most effective means of controlling ***-ditional neutralizing tests of sera are complex and labor-intensive,therefore,a rapid test for detecting neutralizing antibodies and antibody status post-immunization is ***:Based on the fact that antibodies exhibit neutralizing activity by blocking the binding of the S protein receptor-binding domain(S-RBD)to ACE2,we developed a rapid neutralizing antibody test,*** evaluate the sensitivity and specificity,we used 54 positive and 84 negative serum *** also tested the neutralizing activities of monoclonal antibodies(mAbs)and 214 sera samples from healthy individuals im-munized with the inactivated SARS-CoV-2 ***:The sensitivity and specificity of the ACE2-Block ELISA were 96.3%and 100%,*** neu-tralizing mAb screening,ch-2C5 was selected for its ability to block the ACE2-S-RBD interaction.A plaque assay confirmed that ch-2C5 neutralized SARS-CoV-2,with NT 50 values of 4.19,10.63,and 1.074μg/mL against the SARS-CoV-2 original strain,and the Beta and Delta variants,*** the immunized sera samples,the neutralizing positive rate dropped from 82.14%to 32.16%within 4 months ***:This study developed and validated an ACE2-Block-ELISA to test the neutralizing activities of *** a rapid,inexpensive and easy-to-perform method,this ACE2-Block-ELISA has potential applications in rapid neutralizing mAb screening and SARS-CoV-2 vaccine evaluation.

关键词： SARS-CoV-2 Neutralizing antibodies ACE2-Block-ELISA rapid testing

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