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中国科学B辑(英文版) 1986年第6期29卷 599-608页

作者：董新文沈锷 Shanghai Institute of Physiology Academia Sinica Shanghai Brain Research Institute Academia Sinica

By the use of the fluorescent retrograde tracer, Fast Blue (FB), in combination with monoamine fluorescence histochemistry, the origin of monoaminergic input to the region of the nucleus raphe magnus (NRM) was investigated in the rat. After mieroinjection of FB into the NRM, a great number of FB-laboled NA-containing cells were found in the region of the nucleus reticularis lateralis (corresponding to A1 NA areas), the reticular formation just dorsolateral to the nucleus olivaris inferior (corresponding to the A3 NA area), the ventral part of the locus coeruleus (A6 NA area), and the lateral parts of the nucleus raphe dorsalis (B7 area). In the other NA cell groups of the brain stem, FB-labeled cells could not be observed. Serotoninergic input originating from nucleus raphe obscurus (B2), nucleus raphe pallidus (B1) and nucleus raphe pontis (BS-B6) to the NRM was also observed. A large number of cells containing serotonin (5-HT) in the B2 and B6 areas were labeled by FB, while only a few FB-labeled 5-HT

关键词： nucleus raphe dorsalis labeled ventral locus serotonin inferior retrograde illumination

Ca^2＋ in the dorsal raphe nucleus promotes wakefulness via endogenous sleep-wake regulating pathway in the rats

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中国药理学通报 2015年第B11期31卷 45-46页

Aim Serotonergic neurons in the dorsal raphe nucleus （DRN） are involved in the control of sleep- wake states. Our previous study indicated that calcium （Ca^2＋） modulation in the DRN plays an important role in rapid eye movement sleep （REMS） and non-REMS （NREMS） regulation during pentobarbital hypnosis. Presentstudy was designed to investigate the effects of Ca^2＋ in the DRN on sleep-wake regulation and related neuronal mechanism in freely moving rats. Methods CaC12 （25 or 50 nmol） was microinjected into the DRN and sleep pa- rameters were detective by electroencephalogram （EEG） Monoamine neurotransmitters were detected by HPLC- ECD. c-Fos expression in sleep-wake regulating nucleus was detected by immunohistochemistry. Results Our re- sults showed that microinjection of CaC12 （25 or 50 nmol） into the DRN promoted wakefulness and suppressed NREMS including slow wave sleep （SWS） and REMS in freely moving rats. Meanwhile intro-DRN application of CaC12 （25 or 50 nmol） significantly increased serotonin in DRN and hypothalamus, as well increased noradrenaline in locus coeruleus （LC） and hypothalamus. Immunohistochemistry study indicated that the application CaC12 （25 or 50 nmol） into the DRN significantly increased c-Fos expression ratio in wake-promoting neurons including seroton- ergic neurons in the DRN, noradrenergic neurons in the LC and orxinergic neurons in the perifornical nucleus （Pef） , but decreased c-Fos expression ratio of GABAergic sleep-promoting neurons in the ventrolateral preoptic nu- cleus （VLPO）. Conclusion These results suggest that Ca^2＋ in the DRN exert arousal effects via up-regulation of serotonergic function in endogenous sleep-wake regulating pathways.

关键词： Sleep Calcium Dorsal raphe nucleus Serotonin

STUDIES ON RESPIRATORY PHASESWITCHING EFFECTS OF NUCLEUS raphe MAGNUS

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Chinese Science Bulletin 1988年第12期33卷 1043-1048页

作者：王玉田王楠刘磊 Department of physiology Shandong Medical University Jinan

In recent years, considerable progress has been made in research of the physi- ological functions of nucleus raphe magnus (NRM). It is suggested that the neu- rons in NRM play important roles in the modulation of pain... 详细信息

关键词： raphe nucleus expiratory stimulation histogram regarding stimulus delivered shortening initiating

Oxytocin in rat nucleus raphe magnus influences pain modulation

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World Journal of Neuroscience 2012年第2期2卷 119-125页

作者： Yanjuan Pan Zhikui Yin Jun Yang Ying Zhao Xiqing Yan Peiyong Qiu Daxin Wang College of Pharmacy Xinxiang Medical University Xixiang China Jiangsu Su Bei People’s Hospital Yangzhou University Yangzhou China

The main function of Nucleus raphe magnus (NRM) is mostly pain mediation. Our previous study has demonstrated that oxytocin (OXT) regulates antinociception through the central nervous system rather than the peripheral organs, and pain stimulation increases OXT concentration in the NRM. The experiment was designed to investigate OXT in the rat NRM effect on pain modulation. The results showed that 1) pain stimulation increased OXT concentration in NRM perfusion liquid;2) Intra-NRM microinjection of OXT increased the pain threshold in a dose-dependent manner, whereas intra-NRM microinjection of OXT receptor antagonist, desGly-NH2, d(CH2)5[D-Tyr2, Thr-sup-4]OVT decreased the pain threshold;3) NRM pre-treatment with OXT receptor antagonist completely attenuated the pain threshold increase induced by intra-NRM administration of OXT. The data suggested that OXT in NRM was involved in antinociception via OXT receptors.

关键词： Oxytocin Oxytocin Receptor Antagonist Nucleus raphe Magnus Pain Modulation

INHIBITION OF VISCERO-SOMATIC REFLEX BY MIDBRAIN AND THALAMUS STIMULATION: EFFECT OF LESION OF NUCLEUS raphe MAGNUS

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Chinese Science Bulletin 1980年第11期25卷 964-969页

作者：杜焕基赵燕芳郑瑞康 Shanghai Institute of Physiology Academia Sinica

Our previous studies have shown that the nucleus raphe magnus and its adjacent ventromedial reticular formation in the medulla oblongata is able to exert a descending inhibitory effect on the transmission of visceral pain signals in the spinal cord and play an active part in acupunctural analgesia(1-3)The available evidences indicate that the central tegmental tract（TTC）[4,5] and periaqueductal grey（Gcm）[6-8] in the midbrain and the nucleus centrum medianum（CN） in the thalamus are involved in

关键词： analgesia descending visceral nucleus raphe exert stimulation anesthesia 电功 reflex

SPONTANEOUS DISCHARGES OF HABENULAR NUCLEUS AND ITS INHIBITORY ACTION ON NUCLEUS raphe MAGNUS

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Chinese Science Bulletin 1980年第1期25卷 83-88页

作者：王绍江岩肖家思刘敏芝柳苏平 Department of Physiology Bethune Medical College

It has been shown in our previous work that the impulses from acupuncture points might inhibit the impulses from pain points through presynaptic inhibition in the spinal tract nucleus of trigeminal nerve. The stimulation of nucleus raphe magnus might significantly increase the effect of acupuncture analgesia in spinal tract nucleus of trigeminal nerve. It has also been shown that there are descending

关键词： trigeminal acupuncture analgesia descending nucleus ACTION raphe stimulation inhibit intravenous

THE ROLE OF LOCUS COERULEUS-NORADRENERGIC AND DORSAL raphe NUCLEUS-SEROTONERGIC SYSTEMS IN ANALGESIC EFFECT OF HYPOTHA-LAMIC ARCUATE NUCLEUS STIMULATION

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Chinese Science Bulletin 1987年第11期32卷 773-777页

作者：张卫和龚珊殷伟平印其章 Laboratory of Electrophysiology Suzhou Medical College Laboratory of Electrophysiology Suzhou Medical Collegerevious studies ia our laboratory have shown that hypothalamic arcuate nucleus (ARC)locus coeruleus (LG) and dorsal raphe nucleus (DR) play an important role in pain modulation and acupuncture analgesia There is sufficient evidence that LG and DR are main sites concentrated with noradrenergic (NE) and serotonergic (5-HT) neuronal peri-

Previous studies ia our laboratory have shown that hypothalamic arcuate nucleus (ARC),locus coeruleus (LG) and dorsal raphe nucleus (DR) play an important role in pain modulation and acupuncture analgesia, There is sufficient evidence that LG and DR are main sites concentrated with noradrenergic (NE) and serotonergic (5-HT) neuronal peri-

关键词： neuronal analgesia hypothalamic acupuncture stimulation nucleus raphe locus ventricle dorsal

The Role of Dorsal raphe Nucleus and 5-HT in the Electro-acupunctural Inhibition of the cAMP Induced ECoG Epileptiform Activities in Rabbits

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Journal of Medical Colleges of PLA(China) 1990年第2期5卷 151-156页

作者：娄之聪陈水村 Department of Physiolooy First Military Medical University Guangzhou 510515

Like electroacupuncture (EA),electrical stimulation of the dorsal raphe nucle-us (DRN)also inhibits the cAMP induced cortical epileptic waves and the EA inducedinhibition can be abolished or markedly reduced by iv cyproheptadine (CYP) or destruc-tion of DRN by *** results suggest that 5-HT neurons in the DRN mayplay an important role in the EA inhibition of the generation of cAMP induced elec-trocorticogram (ECoG) epileptic waves.

关键词： epileptic waves electrocorticogram cAMP electroacupuncture dorsal raphe nucleus cyproheptadine

INFLUENCE OF ACUPUNCTURE,raphe STIMULATION OR MORPHINE ON INTERCOSTAL DISCHARGES ELICITED BY STIMULATION OF MOTOR CORTEX

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Chinese Science Bulletin 1982年第11期27卷 1235-1240页

作者：沈锷欧阳守马维祥蓝青 Shanghai Institute of Physiology Academia Sinica Shanghai Institute of Physiology Academia Sinica Anhui Trsditional Medieal CollegeHefei

Previous work showed that acupuncture activated bulbar medial reticular formation (including the nucleus raphe magnus) which in turn sent descending impulses via the dorsolateral funiculi (DLF) to inhibit the visceros... 详细信息

关键词： acupuncture descending evoked medial reflex raphe stimulation nucleus inhibit sensory

Colocalization of SOM and NOS in the neurons of raphe nucleiinnervating the pharyngeal muscles in the rats: PRV,SOMandNADPH-d triplelabelingstudy

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Journal of Medical Colleges of PLA(China) 1999年第2期14卷 79-82页

作者：包新民舒斯云陈活姚大卫

Objective: To investigate the colocalization of Somatostatin (SOM ) and NADPH--diaphorase (NADPHd ) of the neurons in raphe nuclei innervating pharyngeal muscles in the rats. Methods: After PRV was injected into the pharyngeal muscles. PRV and SOM immunofluorescence double labeling procedure was completed at first,then proceeded NADPH -d histochemistry. Results: PRV and SOM double--labled cells were present mainly in the nucleus raphe magnus. but some PRV and SOM double labled neurons were found in the other raphe nuclei as well, such as nucleus raphe pallidus. nucleus raphe obsurus, median raphe nucleus and dorsal raphe *** -d positive neurons were also observed in the raphe nuclei. PRV. SOM and NADPH-d triple labeling neurons were found in the nucleus raphe magnus. Conclusion: It is suggested that the colocalization of SOM and NADPH--d of the neurons in the raphe nuclei innervating pharyngeal muscles may play an important role in the coordination of the pharyngeal motility.

关键词： raphe nuclei somatostatin NADPH-d pseudorabies virus colocalization pharynx