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Chinese Medicine Plaster as A New Treatment for Surgical Site Infection in Patients with Cesarean Delivery:A Randomized,Double-Blind,Controlled Trial

引用

Chinese Journal of Integrative Medicine 2023年第6期29卷 483-489页

作者： HAN Guan-ya WU Xiao-li LI Dong-mei CAI Hai-rui ZHOU Jun-jun HE Xiao-bo Department of Obstetrics Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China Department of Medical Intensive Care Unit Ningbo Women and Children's HospitalNingboZhejiang Province(315012)China

Objective To evaluate the efficacy of Chinese plaster containing rhubarb and mirabilite on surgical site infection(SSI)in patients with cesarean delivery(CD)by performing a randomized controlled *** This randomized controlled trial included 560 patients with CD due to fetal head descent enrolled at a tertiary teaching center between December 31,2018 and October 31,*** patients were randomly assigned to a Chinese medicine(CM)group(280 cases)or a placebo group(280 cases)by a random number table,and were treated with CM plaster(made by rhubarb and mirabilite)or a placebo plaster,*** courses of treatment lasted from the day 1 of CD,followed day 2 until *** primary outcome was the total number of patients with superficial,deep and organ/space *** secondary outcome was duration of postoperative hospital stay,antibiotic intake,and unplanned readmission or reoperation due to *** reported efficacy and safety outcomes were confirmed by a central adjudication committee that was unaware of the study-group *** During the recovery process after CD,the rates of localized swelling,redness and heat were significantly lower in the CM group than in the placebo group[7.55%(20/265)vs.17.21%(47/274),P<0.01].The durution of postoperative antibiotic intake was shorter in the CM group than in the placebo group(P<0.01).The duration of postoperative hospital stay was significantly shorter in the CM group than in the placebo group(5.49±2.68 days vs.8.96±2.35 days,P<0.01).The rate of postoperative C-reactive protein elevation(≽100 mg/L)was lower in the CM group than in the placebo group[27.6%(73/265)vs.43.8%(120/274),P<0.01].However,there was no difference in purulent drainage rate from incision and superficial opening of incision between the two *** intestinal reactions and skin allergies were found in the CM *** CM plaster containing rhubarb and mirabilite had an effect on *** is safe for mothers and im

关键词： Chinese medicine plaster rhubarb and mirabilite surgical site infection cesarean delivery randomizedcontrolledtrial

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