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Efficacy of Quxie Capsule in Metastatic Colorectal Cancer:Long-Term Survival Update of A Double-Blind,randomized,Placebo Controlled trial

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Chinese Journal of Integrative Medicine 2022年第11期28卷 971-974页

作者： ZHANG Tong XU Yun SUN Ling-yun HE Bin HAO Jie ZHANG Da YANG Yu-fei Department of Oncology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing(100091)China

Objective:To verify the efficacy of Quxie Capsule in patients with metastatic colorectal cancer(m CRC).Methods:It was a block randomized,double-blind,placebo-controlled *** patients with m CRC were randomized into 2 groups at a 1:1 *** patients in the treatment group received conventional therapy including chemotherapy,radiotherapy,targeted therapy and supportive care,and Chinese herbal medicine combined with Quxie Capsule(each capsule of 0.4 g was orally administered at 50 mg/kg,twice daily,day 1–20,in a 30-day course)for 3 *** patients in the control group received conventional therapy and Chinese herbal medicine combined with placebo for 3 *** outcome measures were overall survival(OS)and progression-free survival(PFS).Subgroup analysis was performed according to therapy lines,right or left-sided colon,targeted therapy and RAS gene status to determine the differences in PFS and OS between the two *** were followed up every 3 months until December 31st,***:Median follow-up time was 19.4 *** median OS was 23.9 months in the treatment group[95%confidence interval(CI)15.9-28.5]vs.14.3 months in the control group(95%CI 11.3-21.4,P0.05).In the subgroups of second-line therapy,non-targeted therapy,RAS gene wild type and left-sided colon,the treatment group showed a significant survival benefit compared with the control group(P<0.05 or P<0.01),***:Quxie Capsule can reduce the risk of death and prolong the OS of patients with m CRC.(Registration *** CTR-IOR-16009733).

关键词： Quxie capsule metastatic colorectal cancer randomized controlles trial Chinese medicine

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