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A randomized controlled clinical trial on Efficacy and Safety of Electroacupuncture on Oral Oxycodone Hydrochloride Prolonged-Release Tablets Related Constipation

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World Journal of Integrated Traditional and Western Medicine 2020年第11期6卷 1-6页

作者： LI Xin SUN Tao Shunyi Hospital Beijing Traditional Chinese Medicine HospitalBeijing 101300China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

Objective:To observe the efficacy and safety of electroacupuncture on oral oxycodone hydrochloride prolonged-release tablets related constipation in Qi(气)deficiency ***:A randomized control trial was conducted in 44 participants,who were divided into the treatment group(electroacupuncture group)and the control group(western medicine group).Two groups were treated by electroacupuncture at Zusanli(ST36),Tianshu(ST25),Zhigou(SJ6)and Shangjuxu(ST37)acupoints every day for 20 mins for 14 consecutive days and lactulose oral solution 30 ml every day for 14 consecutive days *** constipation symptoms,traditional Chinese medicine(TCM)symptoms,quality of life,physical condition before and after the treatments were observed,and the safety indicators were ***:The treatment group was better than the control group in improving constipation symptom score,improving TCM symptom score and improving quality of life score,and the difference was statistically *** was no significant difference between the two groups in improving physical condition *** acupuncture related adverse events were observed in the treatment *** patients in the control group withdrew from the study due to taking emergency defecation therapy and mild diarrhea ***:Electroacupuncture is better than lactulose in the treatment of Qi deficiency constipation related to oxycodone hydrochloride prolonged-release *** can significantly improve the symptoms of constipation,improve the symptoms of TCM,improve the quality of *** is safe and effective.

关键词： Electroacupuncture Opioids randomized controlled clinical trial Constipation

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Effects of Interactive Dynamic Scalp Acupuncture on Motor Function and Gait of Lower Limbs after Stroke:A Multicenter,randomized,controlled clinical trial

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Chinese Journal of Integrative Medicine 2022年第6期28卷 483-491页

作者： ZHANG Shao-hua WANG Yu-long ZHANG Chun-xia ZHANG Chun-ping XIAO Peng LI Qian-feng LIANG Wei-rong PAN Xiao-hua ZHOU Ming-chao Department of Rehabilitation Dapeng New District Nan’ao People’s HospitalShenzhenGuangdong Province518121China Department of Rehabilitation Medicine Shenzhen Second People’s HospitalShenzhenGuangdong Province518037China Department of Rehabilitation Medicine Shenzhen Hospital of Guangzhou University of Chinese MedicineShenzhenGuangdong Province518034China

Objective:To evaluate the effects of interactive dynamic scalp acupuncture(IDSA),simple combination therapy(SCT),and traditional scalp acupuncture(TSA)on motor function and gait of the lower limbs in post-stroke hemiplegia ***:A total of 231 patients with post-stroke hemiplegia was randomly divided into IDSA(78 cases),SCT(78 cases),and TSA(75 cases)groups by a random number *** acupuncture(SA)and lower-limb robot training(LLRT)were both performed in the IDSA and SCT *** patients in the TSA group underwent SA and did not receive *** treatment was administered once daily and 6 times weekly for 8 continuous weeks,each session lasted for 30 *** primary outcome measures included Fugl-Meyer Assessment of the Lower Extremity(FMA-LE),Berg Balance Scale(BBS),Modified Barthel Index(MBI),and 6-min walking test(6 MWT).The secondary outcome measures included stride frequency(SF),stride length(SL),stride width(SW),affected side foot angle(ASFA),passive range of motion(PROM)of the affected hip(PROM-H),knee(PROM-K)and ankle(PROM-A)*** patients were evaluated before treatment,at 1-and 2-month treatment,and 1-,and 2-month follow-up visits,*** events during 2-month treatment were ***:Nineteen patients withdrew from the trial,with 8 in the IDSA group,5 in the SCT group,and 6 in the TSA *** FMA-LE,BBS,6 MWT and MBI scores in the IDSA group were significantly increased after 8-week treatment and2 follow-up visits compared with the SCT and TSA groups(P<0.05 or P<0.01).Compared with pre-treatment,the grade distribution of BBS and MBI scores in the 3 groups were significantly improved at 1,2-month treatment and 2 follow-up visits(P<0.05 or P<0.01).The SF,PROM-H,PFOM-K and PROM-A in the IDSA group was significantly increased compared with the SCT and TSA groups after 8-week of treatment(P<0.05 or P<0.01).Compared with the SCT group,ASFA of the IDSA group was significantly reduced after 8-week of treatment(P<0.05)

关键词： interactive dynamic scalp acupuncture stroke dyskinesia lower extremity motor ability gait self-care capability randomized controlled clinical trial

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Chinese Medicine Sequential Therapy Improves Pregnancy Outcomes after Surgery for Endometriosis-Associated Infertility: A Multicenter randomized Double-blind Placebo Parallel controlled clinical trial

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Chinese Journal of Integrative Medicine 2020年第2期26卷 92-99页

作者： ZHAO Rui-hua LIU Yong LU Dan WU Ying WANG Xiao-yun LI Wei-li ZENG Cheng MENG Qing-wei LIAN Feng-mei ZHOU Jun SHI Yun SUN Wei-wei HAN Qian TANG Yi SHI Guang Departme nt of Gyn ecology Guang'an men HospitalChina Academy of Chinese Medical SciencesBeijing(100053)China Departme nt of Gyn ecology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijing(100026)China Departme nt of Gyn ecology Guan gdong Provincial Hospital of Traditional Chinese MedicineGuangzhou(510120)China Department of Gyn ecology First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei(230031)China Departme nt of Gynecology First Affiliated Hospital of Guangzhou University of Traditional Chinese MedicineGuangzhou(510405)China Department of Gynecology Beijing HospitalBeijing(100730)China Department of Gynecology Dongzhimen Hospital Beijing University of Chinese MedicineBeijing(100700)China Maternal and Child Health Service Center of Pidu District Chengdu(611730)China

Objective:To evaluate the efficacy and safety of Chinese medicine(CM)improving pregnancy outcomes after surgery for endometriosis-associated ***:A multicenter,randomized,doubleblind placebo parallel controlled clinical trial was designed.A total of 202 patients who had laparoscopy for endometriosis-associated infertility with qi stagnation and blood stasis syndrome were included and randomly divided into the CM treatment group and placebo control group at a ratio of 1:1 using a central block randomization from May 2014 to September 2017,101 patients in each *** two groups received continuous intervention at 1–5 days after surgery,for 6 menstrual *** ovulation,the CM group was treated Huoxue Xiaoyi Granule(活血消异颗粒);after ovulation,Bushen Zhuyun Granule(补肾助孕颗粒)was *** control group was treated with *** ultrasonography was performed every menstrual cycle during the treatment,and female hormone levels in the follicular and luteal phases were measured during the 1 st,3 rd and 6 th menstrual *** analysis was continued until *** primary outcomes were clinical pregnancy rate and pregnancy outcome,and the secondary outcomes were follicular development and endometrial *** evaluations were performed before and after ***:(1)clinical pregnancy and live birth rates:the clinical pregnancy and live birth rates of the CM group were significantly higher than those of the placebo group[44.6%(45/101)vs.29.7%(30/101),34.7%(35/101)vs.20.8%(21/101),both P<0.05].(2)Follicle development:the incidence of dominant follicles,rate of cumulative cycle ovulation,and rate of cumulative cycle mature follicle ovulation were significantly higher in the CM group than those in the placebo group[93.8%(350/373)vs.89.5%(341/381),80.4%(275/342)vs.69.1%(253/366),65.8%(181/275)vs 56.1%(142/253),P<0.05 or P<0.01]).The incidence of cumulative cycle luteinized unruptured follicle syndrome was significantly low

关键词： endometriosis infertility Huoxue Xiaoyi Granule Bushen Zhuyun Granule pregnancy rate randomized controlled clinical trial Chinese medicine

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Systematic review and Meta-analysis of 26 randomized controlled clinical trials of Compound Danshen Dripping Pill for non-proliferating diabetic retinopathy

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Chinese Herbal Medicines 2022年第1期14卷 142-153页

作者： Yu Wang Lei Hao Zhipeng Huo Yuanxue Liu Yujing Sun Zhaohui Song State Key Laboratory of Core Technology in Innovative Chinese Medicine Tasly AcademyTasly Holding Group Co.Ltd.Tianjin 300410China

Objective:Diabetic retinopathy(DR) is the retinal consequence of chronic progressive diabetic microvascular leakage and ***-proliferating diabetic retinopathy(NPDR) is the early stage of *** eventually occurs to some degree in all patients with diabetes *** recent years,many clinical trials have shown that Compound Danshen Dripping Pill(CDDP) may be associated with the improvement of NPDR *** aim of this study was to quantitatively summarize the association between CDDP and the therapeutic effects of ***:It was conducted that a systematic literature search of Pub Med,Web of Science,CNKI,VIP and Wanfang Data updated in June 2020 with the following search terms:"diabetic retinopathy° or"retinopathy° or "DR° or "NPDR°,in combination with "Compound Danshen Dripping Pill° or "Salvia miltiorrhiza° or "Danshen°.Risk ratio(RR) and weighted mean difference(WMD) with their 95% confidence interval(CI) was calculated between treatment and control *** sensitivity analyses were undertaken by removing each individual study when high heterogeneity *** analysis,Metaregression,and publication bias analysis were also *** strength of evidence was evaluated with the Grading of Recommendation,Assessment,Development,and Evaluation(GRADE) ***:Twenty-six RCTs involving 2047 subjects were included to conduct a Meta-analysis after screening the studies,extracting the data,and assessing the study *** Stata15.0 software was utilized for ***-analysis indicated that curative effects of treatment group with CDDP was significantly better than control [RR = 0.54,95% CI(0.40,0.73);moderate-quality evidence].In addition,the results showed that CDDP was significantly associated with improving retinal hemorrhages[WMD =-0.62,95% CI(-0.78,-0.46);low-quality evidence],the vision [WMD = 0.14,and 95% CI(0.09,0.19),low-quality evidence],fundus fluorescence angiography [RR = 0.37 and 95% CI(0.23,0.60);low-qualit

关键词： Compound Danshen Dripping Pill diabetic retinopathy Meta-analysis randomized controlled clinical trial systemic review

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Calcium dobesilate for diabetic retinopathy: a systematic review and meta-analysis

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Science China(Life Sciences) 2015年第1期58卷 101-107页

作者： ZHANG XinYuan LIU Wei WU ShanShan JIN JingLong LI WeiHong Wang NingLi Beijing Institute of Ophthalmology Tongren Eye CentreTongren HospitalCapital Medical University University of Science and Technology Beijing Department of medical resources Beijing Tongren HospitalCapital Medical University Department of Epidemiology and Bio-statistics Peking University Health Science Center

Many randomized clinical controlled trials have confirmed the efficacy and safety of calcium dobesilate in treating diabetic retinopathy(DR).This systematic review critically evaluated the evidence that links calcium dobesilate to *** this fixed-effects meta-analysis,a total of 221 pertinent English-language articles published between January 1975 and October 2013 were *** searches of PUBMED,Springer Link and the Cochrane clinical trials Database were conducted using the keywords "diabetic retinopathy" and "calcium dobesilate".The extracted information included the study design,inclusion and exclusion criteria,setting,sample size,participant mean age,treatment regime,mean change in best corrected visual acuity,laboratory parameters,capillary fragility,intraocular pressure and fundus manifestations based on the findings of fluorescent *** summary statistics indicated that calcium dobesilate was significantly associated with improving retinal microaneurysms(RR: 0.62,95%CI: 0.42?0.90,P=0.01),retinalhemorrhages(RR: 0.39,95% CI: 0.17?0.88,P=0.02); exudates(RR: 0.31,95% CI: 0.12?0.81,P=0.02),reduction of whole blood viscosity(MD: ?0.57 CP,95% CI: ?0.75 to ?0.38,P<0.001),plasma viscosity(MD: ?0.36 CP,95% CI: ?0.63 to ?0.09,P=0.01) and blood cholesterol(MD: ?0.48 mg m L?1,95% CI: ?0.64?0.33,P<0.00001).Intraocular pressure was also significantly reduced(MD: ?5.59 mm Hg,95% CI: ?6.69 to ?4.50,P<0.00001).The results indicate that calcium dobesilate effectively treats DR at the systematic and local ocular levels.

关键词： diabetic retinopathy calcium dobesilate randomized controlled clinical trial systemic review meta-analysis

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Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients

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Neural Regeneration Research 2022年第8期17卷 1809-1813页

作者： Jia-Ni Li Chen-Chen Xie Chang-Qing Li Gui-Fang Zhang Hao Tang Chuan-Na Jin Jing-Xi Ma Lan Wen Ke-Ming Zhang Ling-Chuan Niu Department of Neurology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology Chongqing General HospitalUniversity of Chinese Academy of SciencesChongqingChina Chongqing Key Laboratory of Neurodegenerative Diseases ChongqingChina Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina clinical College Chongqing Medical and Pharmaceutical CollegeChongqingChina

Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus *** have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute ***,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after *** double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical *** subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation *** follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation *** were no obvious side *** findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.

关键词： activity of daily living early stage treatment emotional disorder limb dysfunction neural regeneration randomized controlled clinical trial rehabilitation safety of treatment stroke transcutaneous auricular-vagus nerve stimulation

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clinical efficacy of low-dose emetine for patients with COVID-19:a real-world study

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Journal of Bio-X Research 2021年第2期4卷 53-59页

作者： Song Fan Qi Zhen Cheng Chen Wenjun Wang Qibing Wu Huihui Ma Chengyuan Zhang Li Zhang Baojing Lu Huiyao Ge Liang Yong Bao Li Yafen Yu Weiwei Chen Yiwen Mao Guangbo Qu Li Su Aoli Wang Zhen Ding Haiwen Li Jin Zhang Yonglian Wang Yufeng Gao Xihai Xu Zhongming Zhu Jun Chen Long Zhang Hongqiang Liang Song Wu Meng Huang Quan Xia Ping Li Yehuan Sun Chaozhao Liang Wei Wei Qingsong Liu Liangdan Sun Department of Urology the First Affiliated Hospital of Anhui Medical UniversityInstitute of UrologyAnhui Medical University and Anhui Province Key Laboratory of Genitourinary Diseases Department of Dermatology the First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of DermatologyAnhui Medical UniversityMinistry of EducationInflammation and Immune Mediated Diseases Laboratory of Anhui Province High Magnetic Field Laboratory Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of Sciences Department of Radiation Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei Anhui Lixin County Hospital of Traditional Chinese Medicine Bozhou Department of Respiratory Medicine Anhui Feidong County People’s Hospital Center for Scientific Research of the First Affiliated Hospital of Anhui Medical University Department of Microbiology School of Basic Medical ScienceAnhui Medical University Comprehensive Lab College of BasicAnhui Medical University Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical University Traditional and Western Medicine(TCM)-Integrated Cancer Center of Anhui Medical University the Department of Traditional and Western Integrative Medicine Oncologythe First Affiliated Hospital of Anhui Medical University Department of Respiratory Medicine Binhu Hospital of Hefei The Third Affiliated Hospital of Anhui Medical University the First Affiliated Hospital of Zhengzhou University The Second People’s Hospital of Hefei The Department of Infectious Diseases the First Affiliated Hospital of Anhui Medical University The Department Pulmonary and Critical Care Medicine the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui Province Anhui Suzhou Hospital SuzhouJiangsu Province Anhui Feidong County People’s Hospital Department of Pharmacy the First Affiliated Hospital of Anhui Medical University Institute of clinical Pharmacology Anhui Medical UniversityKey Laborat

Objective:Emetine,an isoquinoline alkaloid that is enriched at high concentrations in the lung,has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019(COVID-19).Methods:In this real-world study,63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province,China from February to March ***-nine patients from Wuhan Fangcang Shelter Hospital were assigned to a pragmatic randomized controlled clinical trial,and 24 patients from the 5 COVID-19-designated hospitals in Anhui Province underwent a real-world *** medication course of emetine was less than 10 *** main symptoms and adverse reactions of all patients were observed and *** primary outcome measure was the time required for a negative SARS-CoV-2 RNA result or the negative result rate on day *** outcomes included axillary temperature,transcutaneous oxygen saturation,and respiratory frequency *** study was approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University on February 20,2019(approval ***2020-03-19)and was registered with the Chinese clinical trial Registry on February 20,2019(registration number:ChiCTR2000030022).Results:The oxygen saturation values were higher in the treatment group than in the control group on the first day after enrollment for patients treated at Fangcang Shelter *** axillary body temperature,respiratory rate,and oxygen saturation among patients in Fangcang Shelter Hospital were related to the time effect but not to the intervention *** respiratory rate and oxygen saturation of patients in the Anhui designated hospitals were related to the intervention measures but not to the time *** axillary body temperature of patients in A

关键词： arbidol COVID-19 emetine randomized controlled clinical trial real-world study

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