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STUDY OF THE MECHANISM OF ARTEMISINE CAPILLARIES AND radix curcumae PREVENTING GALLSTONE FORMATION INDUCED BY HIGH CHOLESTEROL DIET IN GUINEA PIGS

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Journal of Pharmaceutical Analysis 1999年第1期13卷 62-65页

作者：石景森任斌马庆久孟清翠汪涛田和平韩梅荣卢云刘绍浩吴谨光 Dept. of Hepatal-Biliary Surgery First Affiliated Hospital Xi'an Medical University Xi'an 710061 China

To study the effect of chinese herbal medicine preventing gallstone formation, morphology of livers and gallbladders as well as conjugated bile acids of the bile. 58 female guinea pigs were randomly divided into three groups. The control group was fed on normal diet; the lithogenous groups was high cholesterol diet (HCD) and the antilithic group was high cholesterol and the chinese herbal medicine capsule (13 5 g/kg). 8 weeks later the guinea pigs were killed. Liver and gallbladder were removed for light and electroscope observation. Gallbladder bile were withdrawn and gallbladder were collected. The minute construction of gallstones were observed by scanning electron microscope and gallstone components were quantified by Fourier Transform Infrand Spectros Copy (FT IR). The morphology of liver and gallbladder were observed by light microscope and transmission electron microscope. Conjugated bile acid of biles were determined by Thin layer Chromatograph. The effect of chinese herbal medicine preventing gallstone formation, morphololgy of livers and gallbladders as well as conjugated bile acids of the bile were also observed. We measured conjugated bile acids in all groups and found that decreased in lithogenic group and increased notably in antilithic group (P<0 01) . The gallstone formation rate was 100% when the animals were fed on HCD in lithogenic group. The rate decreased to 5 3% when the animals were fed on HCD and Chinese herbal medicine capsule inantilithic group. It indicates that changes in diet is an important factor in the process of gallstone formation and the chinese herbal medicine can prevent gallstone formation effectively.

关键词： artemisiae capillaris radix curcumae gallstone conjugated bile acid

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Comparative analysis of essential oils found in Rhizomes curcumae and radix curcumae by gas chromatography-mass spectrometry

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Journal of Pharmaceutical Analysis 2011年第3期1卷 203-207页

作者： Di-Ya Lu Yan Cao Ling Li Zhen-Yu Zhu Xin Dong Hai Zhang Yi-Feng Chai Zi-Yang Lou School of Pharmacy Second Military Medical University Shanghai 200433 China Shanghai Key Laboratory for Pharmaceutical Metabolite Research Shanghai 200433 China Department of Pharmacy Eastern Hepatobiliary Surgery Hospital Shanghai 200438 China

A comparison of the volatile compounds in Rhizomes curcumae （Ezhu） and radix curcumae （Yujin） was undertaken using gas chromatography mass spectrometi-y （GC-MS）. Ultrasonic extraction and GC-MS methods were developed for the simultaneous determination of five sesquiterpenes, namely, α-pinene, β-elemene, curcumol, germacrone and curdione, in Ezhu and Yunjin. Good linearity （r〉0.999） and high inter-day precision were observed over the investigated concentration ranges. The validated method was successfully used for the simultaneous determination of five sesquiterpenes in Ezhu and Yujin. The quantitative method can be effectively used to evaluate and monitor the quality of Chinese curcuma in clinical use.

关键词： Gas chromatography-mass spectrometry Rhizomes curcumae radix curcumae Volatile compounds Quality control

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