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Loss of NEIL3 activates radiotherapy resistance in the progression of prostate cancer

Cancer Biology & Medicine 2022年第8期19卷 1193-1210页

作者： Qiong Wang Zean Li Jin Yang Shirong Peng Qianghua Zhou Kai Yao Wenli Cai Zhongqiu Xie Fujun Qin Hui Li Xu Chen Kaiwen Li Hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Pathology School of MedicineUniversity of VirginiaCharlottesvilleVA 22908USA Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Radiology Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China

Objective:To explore the genetic changes in the progression of castration-resistant prostate cancer(CRPC)and neuroendocrine prostate cancer(NEPC)and the reason why these cancers resist existing ***:We employed our CRPC cell line microarray and other CRPC or NEPC datasets to screen the target gene *** transfection and RNA interference were used to construct overexpression and knockdown cell *** and animal models of radiotherapy were established by using a medical electron linear *** cytometry was used to detect apoptosis or cell cycle *** blot and qPCR were used to detect changes in the protein and RNA ***:TCGA and clinical patient datasets indicated that NEIL3 was downregulated in CRPC and NEPC cell lines,and NEIL3 was correlated with a high Gleason score but a good *** functional studies demonstrated that NEIL3 had no effect on the proliferation and migration of PCa ***,cell and animal radiotherapy models revealed that NEIL3 could facilitate the radiotherapy sensitivity of PCa cells,while loss of NEIL3 activated radiotherapy ***,we found that NEIL3 negatively regulated the expression of ATR,and higher NEIL3 expression repressed the ATR/CHK1 pathway,thus regulating the cell ***:We demonstrated that NEIL3 may serve as a diagnostic or therapeutic target for therapy-resistant patients.

关键词： CRPC NEIL3 NEPC prostate cancer radiotherapy resistance

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Research of the relationship between radiotherapy and microRNAs

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The Chinese-German Journal of Clinical Oncology 2012年第5期11卷 285-289页

作者： Jiao yang Ximing Xu Yanrong Hao Cancer Center Renmin Hospital of Wuhan University Wuhan 430060 China Cancer Center People's Hospital of Guangxi Autonomous Region Nanning 530000 China

MicroRNAs(miRNAs) are endogenous short non-coding RNAs,and play a pivotal role in regulating a variety of cellular processes,including proliferation and apoptosis,both of which are cellular responses to radiation *** response to radiation,multiple miRNAs show altered expression,which act as oncogenes or tumor *** evidence has also shown that some miRNAs have radiotherapy sensitization or radiation resistance role in malignant *** review focuses on analysis of these characteristics and mechanisms of miRNAs,and will provide some insight into the therapeutic application of radiation.

关键词： microRNAs (miRNAs) radiotherapy sensitization radiotherapy resistance dysregulation mechanism

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