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GPU-accelerated three-dimensional reconstruction method of the Compton camera and its application in radionuclide imaging

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Nuclear Science and Techniques 2023年第4期34卷 54-68页

作者： Ren-Yao Wu Chang-Ran Geng Feng Tian Zhi-Yang Yao Chun-Hui Gong Hao-Nan Han Jian-Feng Xu Yong-Shun Xiao Xiao-Bin Tang Department of Nuclear Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Engineering Physics Tsinghua UniversityBeijing 100084China School of Environmental and Biological Engineering Nanjing University of Science and TechnologyNanjing 210094China JYAMS PET Research and Development Limited Nanjing 211100China

A novel and fast three-dimensional reconstruction method for a Compton camera and its performance in radionuclide imaging is proposed and analyzed in this study. The conical surface sampling back-projection method with scattering angle correction(CSS-BP-SC) can quickly perform the back-projection process of the Compton cone and can be used to precompute the list-mode maximum likelihood expectation maximization(LM-MLEM). A dedicated parallel architecture was designed for the graphics processing unit acceleration of the back-projection and iteration stage of the CSS-BP-SC-based LM-MLEM. The imaging results of the two-point source Monte Carlo(MC) simulation demonstrate that by analyzing the full width at half maximum along the three coordinate axes, the CSS-BP-SC-based LM-MLEM can obtain imaging results comparable to those of the traditional reconstruction algorithm, that is, the simple back-projection-based LM-MLEM. The imaging results of the mouse phantom MC simulation and experiment demonstrate that the reconstruction results obtained by the proposed method sufficiently coincide with the set radioactivity distribution, and the speed increased by more than 664 times compared to the traditional reconstruction algorithm in the mouse phantom experiment. The proposed method will further advance the imaging applications of Compton cameras.

关键词： Compton camera Three-dimensional reconstruction radionuclide imaging GPU

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Application of radionuclide imaging to hepatic impact injury in rabbits

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Chinese Journal of Traumatology 2004年第1期7卷 45-48页

作者：金榕兵麻晓林温建良唐维佳 Research Institute of Surgery

Objective: To investigate the role and clinical value of radionuclide imaging in hepatic impact injuries in rabbits. Methods: Rabbits were experimentally impacted on the liver with BIM IV bio impact machine. Liver imaging was performed with 99m Tc labeled sodium phytate. Liver blood pool imaging was performed with 99m Tc stannous pyrophosphate labeled red blood cells. The results of radionuclide imaging were compared with the anatomic results. Results: There was significant difference between the images of the injured liver and the control. Radio diminution and defect were shown in the injured liver areas. Various sorts of abnormal radioactivity distribution were observed with hepatic blood pool imaging. The results of the liver imaging and liver blood pool imaging were accorded with the results of the anatomic findings. Conclusions: radionuclide imaging may well display the changes of hepatocellular structures and functions after injury, which is valuable in locating the concrete injured position and differentiating the injured degrees of liver.

关键词： Liver Wounds and injuries radionuclide imaging

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Development and evaluation of a double-plane detector system for multi-radionuclide imaging

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Radiation Detection Technology and Methods 2019年第3期3卷 178-186页

作者： Zhen‑Rui Lu Xian‑Chao Huang Zhi‑Ming Zhang Ying‑Jie Wang Da‑Quan Cao Wei Zhou Xiao‑Yue Gu Xiao‑li Sun Pei Chai Hao‑Hui Tang Dao‑Wu Li Lin Li Chuang‑Xin Ma Long Wei Beijing Engineering Research Center of Radiographic Techniques and Equipment Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Purpose To develop a multi-radionuclide imaging system with a flexible and compact structure that has a potential for breast and other applications,and to evaluate its performances under both positron emission tomography and single photon emission imaging *** The plane detector was composed of 5×6 blocks with an effective detection area of 168.6 mm×202.4 *** block consisted of a 16×16 LYSO *** pixel size is 1.9 mm×1.9 mm×15 *** 8×8 silicon photomultiplier(SiPM)array with SensL’s C-30035 sensors was coupled to the LYSO array,separated by a 1.5-mm-thick *** minimize the influence of temperature on the detector,the active part of the front-end electronics was kept away from ***-designed data acquisition system and reconstruction software were utilized to evaluate the performances of the whole *** All the blocks had excellent pixels *** average energy resolution of 11.39%for 511 keV and 21.37%for 140 keV was *** the PET mode,the best spatial resolution was better than 2 mm and the system sensitivity reached up to 11.05%at 60 mm *** the single photon emission imaging mode,a spatial resolution better than 3 mm was *** The results indicated that the system has a good overall performance and can be used in breast imaging and other general PET *** also has the potential to be used for single photon emission *** pursuit of a better spatial resolution of cross-plane,PSF and DOI technology will be developed in the next *** specific applications,further improvement of the detector system such as performance evaluation with phantoms will be carried out.

关键词： Plane detector Silicon photomultiplier(SiPM) radionuclide imaging Positron emission tomography(PET) Single photon emission imaging

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Advantages of the intradermal lymphoscintigraphy

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World Journal of Radiology 2024年第7期16卷 241-246页

作者： Girolamo Tartaglione Department of Nuclear Medicine Cristo Re HospitalRome 00167Italy

Lymphoscintigraphy is a nuclear medicine procedure that uses a small quantity of radioactive particles for visualizing the lymphatic ***,the radiotracer was injected subcutaneously,but the quality of lymphatic path imaging was scarce due to high *** radiotracer injection is considered the modern-day intralymphatic *** propose rest/stress intradermal lymphoscintigraphy for the diagnosis,staging and surgical planning of *** and minor findings were described in primary and secondary *** on the in-depth information of the lymphatic pathways,physiotherapists and microsurgeons can obtain important functional information in patients’selection to treat with physical treatments and/or undergo microsurgery.

关键词： Intradermal injection Lymphoscintigraphy Exercise Rest Stress Lymphedema radionuclide imaging Lymphatic system

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A novel denoising framework for cerenkov luminescence imaging based on spatial information improved clustering and curvature-driven diffusion

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Journal of Innovative Optical Health Sciences 2018年第4期11卷 35-42页

作者： Xin Cao Yi Sun Fei Kang Lin Wang Huangjian Yi Fengjun Zhao Linzhi Su Xiaowei He School of Information Science and Technology Northwest University Xi'an Shaanxi 710069P.R.China Department of Nuclear Medicine Xijing Hospital Fourth Military Medical University Xi'anShaanxi 710032P.R.China

With widely availed clinically used radionuclides,Cer enkov luminescence imaging(CLI)has become a potential tool in the field of optical molecular ***,the impulse noises introduced by high-energy gamma rays that are generated during the decay of radionuclide reduce the image quality significantly,which affects the acauracy of quantitative analysis,as well as the three dimensional *** this work,a novel denoising framework based on fuzzy dlustering and curvat ure driven difusion(CDD)is proposed to remove this kind of impulse *** improve the accuracy,the F u1zzy Local Information C-Means algorithm,where spatial information is evolved,is *** evaluate the per formance of the proposed framework sys-tematically with a series of experiments,and the corresponding results demonstrate a better denoising effect than those from the commonly used median filter *** hope this work may provide a useful data pre processing tool for CLI and its following studies.

关键词： Cerenkov luminescence imaging image processing radionuclide imaging

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Nanogels as Contrast Agents for Molecular imaging

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Chinese Journal of Chemistry 2016年第6期34卷 547-557页

作者： Jianzhi Zhu Wenjie Sun Xiangyang Shi College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 China

Nanogels （NGs） as soft nanosized materials have gained a variety of interests in biomedical fields. The versatile NG scaffolds with 3-dimensional spherical shape, high loading efficiency, tunable surface functionalization, and excellent biocompatibility afford their uses as carrier to load mono- or multi-mode molecular imaging contrast agents （CAs）. This review summarizes the synthesis routes and applications of NGs as CAs for molecular imaging applications including magnetic resonance （MR）, computed tomography （CT）, radionuclide, optical, and dual/mul- ti-modality imaging.

关键词： nanogels contrast agents MR imaging CT imaging radionuclide imaging optical imaging dual/multi-modality imaging

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Technetium-99m-labeled macroaggregated albumin lung perfusion scan for diagnosis of hepatopulmonary syndrome: A prospective study comparing brain uptake and whole-body uptake

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World Journal of Gastroenterology 2020年第10期26卷 1088-1097页

作者： He Zhao Jiaywei Tsauo Xiao-Wu Zhang Huai-Yuan Ma Ning-Na Weng Gong-Shun Tang Xiao Li Department of Interventional Therapy National Cancer Center/National Clinical Research Center/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Nuclear Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Hepatopulmonary syndrome (HPS) is an arterial oxygenation defect induced by intrapulmonary vascular dilatation (IPVD) in the setting of liver disease and/or portal *** syndrome occurs most often in cirrhotic patients(4%-32%) and has been shown to be detrimental to functional status,quality of life,and *** diagnosis of HPS in the setting of liver disease and/or portal hypertension requires the demonstration of IPVD (i.e.,diffuse or localized abnormally dilated pulmonary capillaries and pulmonary and pleural arteriovenous communications) and arterial oxygenation defects,preferably by contrast-enhanced echocardiography and measurement of the alveolar-arterial oxygen gradient,*** To compare brain and whole-body uptake of technetium for diagnosing *** Sixty-nine patients with chronic liver disease and/or portal hypertension were prospectively *** uptake and whole-body uptake were calculated using the geometric mean of technetium counts in the brain and lungs and in the entire body and lungs,*** Thirty-two (46%) patients had IPVD as detected by *** demographics and clinical characteristics of the patients with and without IPVD were not significantly different with the exception of the creatinine level (0.71±0.18 mg/dL vs 0.83±0.23 mg/dL;P=0.041),alveolararterial oxygen gradient (23.2±13.3 mmHg vs 16.4±14.1 mmHg;P=0.043),and arterial partial pressure of oxygen (81.0±12.1 mmHg vs 90.1±12.8 mmHg;P=0.004).Whole-body uptake was significantly higher in patients with IPVD than in patients without IPVD (48.0%±6.1%vs 40.1%±8.1%;P=0.001).The area under the curve of whole-body uptake for detecting IPVD was significantly higher than that of brain uptake (0.75 vs 0.54;P=0.025).The optimal cut-off values of brain uptake and whole-body uptake for detecting IPVD were 5.7%and 42.5%,respectively,based on Youden’s *** sensitivity,specificity,and accuracy of brain uptake

关键词： Portal hypertension Intrapulmonary vascular dilations radionuclide imaging Technetium-99m-labeled macroaggregated albumin lung perfusion scan Diagnostic tests Sensitivity and specificity

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Classification of hepatobiliary scintigraphy patterns in segmented gallbladder according to anatomical discordance

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World Journal of Clinical Cases 2023年第11期11卷 2423-2434页

作者： Yun-Chae Lee Won-Sik Jung Chang-Hun Lee Seong-Hun Kim Seung-Ok Lee Division of Gastroenterology Department of Internal MedicineJeonbuk National University Medical SchoolJeonju 54907JeonbukSouth Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907JeonbukSouth Korea

BACKGROUND Hepatobiliary scintigraphy(HBS)is a useful diagnostic imaging technique that uses radiotracers to evaluate the function of the gallbladder(GB)and biliary *** segmented GB,some HBS images reveal a discordant GB boundary as compared to anatomical *** To evaluate the characteristics of HBS in segmented GB and determine the clinical relevance according to HBS *** A total of 268 patients with chronic cholecystitis,gallstones,or biliary colic symptoms who underwent HBS between 2011 and 2020 were *** GB was defined as segmental luminal narrowing of the GB body on computed tomography(CT)or magnetic resonance(MR)images,and HBS was examined 1 mo before or after CT or *** GB was classified into 3 types based on the filling and emptying patterns of the proximal and distal segments according to the characteristics of HBS images,and GB ejection fraction(GBEF)was identified:Type 1 was defined as a normal filling and emptying pattern;Type 2 was defined as an emptying defect on the distal segment;and Type 3 was defined as a filling defect in the distal *** Segmented GB accounted for 63 cases(23.5%),including 36 patients(57.1%)with Type 1,18 patients(28.6%)with Type 2,and 9 patients(14.3%)with Type 3 emptying ***,approximately 43%of HBS images showed a discordant pattern as compared to anatomical imaging of segmented *** there were no significant differences in clinical symptoms,rate of cholecystectomy,or pathological findings based on the type,most gallstones occurred in the distal *** GBEF was 62.50%±24.79%for Type 1,75.89%±17.21%for Type 2,and 88.56%±7.20%for Type *** 1 showed no difference in reported GBEF compared to the non-segmented GB group(62.50%±24.79%vs 67.40%±21.78%).In contrast,the reported GBEF was higher in Types 2 and 3 with defective emptying and filling when compared to Type 1(80.11%±15.70%vs 62.57%±24.79%;P=0.001).CONCLUSION In segmented GB,discordance i

关键词： Gallbladder Segmented Gallbladder emptying radionuclide imaging Misdiagnosis Cholecystitis

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Hip prosthetic loosening:A very personal review

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World Journal of Orthopedics 2021年第9期12卷 629-639页

作者： Bengt Mjöberg Department of Orthopedics Lund UniversityLund SE-22100Sweden

Hip prosthetic loosening is often difficult to detect at an early stage,and there has been uncertainty for a long time as to when the loosening occurs and thus to the basic *** comparing different diagnostic methods,we found that loosening is best defined as prosthetic migration and measured by radiostereometric *** evidence indicates that poor interlock,poor bone quality,and resorption of a necrotic bone bed may initiate loosening during or shortly after surgery;this forms the basis of the theory of early *** factors do affect the subsequent progression of loosening,which may increase subclinically during a long period of ***,the loosening may be detected on standard radiographs and may be interpreted as late loosening but should to be interpreted as late detection of *** theory of early loosening explains the rapid early migration,the development of periprosthetic osteolysis and granulomas,the causality between wear and loosening,and largely the epidemiology of clinical failure of hip *** discussed are definition of loosening,the pattern of early migration,the choice of migration threshold,the current understanding of loosening,a less exothermic bone cement,cemented taper-slip stems,a new exciting computed tomography-based technique for simpler implant migration studies,and research suggestions.

关键词： Hip prosthesis Prosthesis failure Radiostereometric analysis Bone resorption Bone cements radionuclide imaging

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Evaluation of ^(99m)Tc Labeled Diadenosine Tetraphosphate as an Atherosclerotic Plaque imaging Agent in Experimental Models

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2006年第3期26卷 278-280页

作者：曹卫张永学安锐 Department of Nuclear Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

The potential of ^99mTc labeled P^1, P^4-di （adenosine-5 ＇）-tetraphosphate （Ap4A） for imaging experimental atherosclerotic plaques was evaluated in New Zealand white （NZW） rabbits. To label the ^99mTc to Ap4A, stannous tartrate solution was used. ^99mTc-Ap4A was purified on a Sephadex G-25 column. The radiochemistry purities of ^99mTc-Ap4A were 85% to 91%. Biodistribution study revealed ^99mTc-Ap4A cleared from blood rapidly. Thirty min after ^99mTc-Ap4A administrated on NZW atherosclerotic rabbits, lesion to blood （target/blood, T/B） ratio was 3. 17 ±1.27, and lesions to normal （target/non-target, T/NT） ratio was 5.23 ±1.87. Shadows of atherosclerotic plaques were clearly visible on radioautographic film. Aortas with atherosclerotic plaques also could be seen on ex vivo gamma camera images. Atherosclerotic abdominal aortas were clearly visible on in vivo images 15 min to 3 h after ^99mTc-Ap4A administration. ^99mTc-labeled Ap4A can be used for rapid noninvasive detection of experimental atherosclerotic plaque.

关键词： technetium diadenosine tetraphosphate atherosclerotic plaque radionuclide imaging

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