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Human umbilical cord mesenchymal stem cell-loaded amniotic membrane for the repair of radial nerve injury

Neural Regeneration Research 2013年第36期8卷 3441-3448页

作者： Zhi Li Hanjiao Qin Zishan Feng Wei Liu Ye Zhou Lifeng Yang Wei Zhao Youjun Li Affiliated Central Hospital of Shenyang Medical College Department of Endocrinology and Metabolism First Clinical Hospital of Norman Bethune College of Medicine Jilin University Shengjing Hospital China Medical University Department of Human Anatomy and Histoembryology Norman Bethune University of Medical Science

In this study, we loaded human umbilical cord mesenchymal stem cells onto human amniotic membrane with epithelial cells to prepare nerve conduits, i.e., a relatively closed nerve regeneration chamber. After neurolysis, the injured radial nerve was enwrapped with the prepared nerve conduit, which was fixed to the epineurium by sutures, with the cell on the inner surface of the conduit. Simultaneously, a 1.0 mL aliquot of human umbilical cord mesenchymal stem cell suspension was injected into the distal and proximal ends of the injured radial nerve with 1.0 cm intervals. A total of 1.75 x 107 cells were seeded on the amniotic membrane. In the control group, patients received only neurolysis. At 12 weeks after cell transplantation, more than 80% of patients exhibited obvious improvements in muscular strength, and touch and pain sensations. In contrast, these improvements were observed only in 55-65% of control patients. At 8 and 12 weeks, muscular electrophysiological function in the region dominated by the injured radial nerve was significantly better in the transplantation group than the control group. After cell transplantation, no immunological rejections were observed. These findings suggest that human umbilical cord mesenchymal stem cell-loaded amniotic membrane can be used for the repair of radial nerve injury.

关键词： neural regeneration stem cells peripheral nerve injury cells radial nerve amniotic membrane nerve electrophysiology motor sensory neuroregeneration human umbilical cord mesenchymal stem conduit nerve regeneration chamber

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Ultrasonographic reference values for assessing normal radial nerve ultrasonography in the normal population

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Neural Regeneration Research 2014年第20期9卷 1844-1849页

作者： Jun Chen Shan Wu Jun Ren Department of Neurology Affiliated Hospital of Guiyang Medical College Lianshui County Hospital of Jiangsu Proviuce Pharmacology University of Wyoming College of Health Sciences Wyoming INBRE ProgramLaramieWYUSA

High-resolution ultrasound has been used recently to characterize median and ulnar nerves, but is seldom used to characterize radial nerves. The radial nerve is more frequently involved in en- trapment syndromes than the ulnar and median nerves. However, the reference standard for normal radial nerves has not been established. Thus, this study measured the cross-sectional areas of radial nerves of 200 healthy male or female volunteers, aged 18 to 75, using high-resolution ultrasound. The results showed that mean cross-sectional areas of radial nerves at 4 cm upon the lateral epicondyle of the humerus and mid-humerus （midpoint between the elbow crease and axilla） were 5.14± 1.24 and 5.08 ± 1.23 mm2, respectively. The age and the dominant side did not affect the results, but the above-mentioned cross-sectional areas were larger in males （5.31± 1.25 and 5.19 ±1.23 mm2） than in females （4.93 ± 1.21 and 4.93 ± 1.23 mm2, respectively）. In addition, the cross-sectional areas of radial nerves were positively correlated with height and weight （r = 0.38, 0.36, respectively, both P 〈 0.05）. These data provide basic clinical data for the use of high-resolution ultrasound for the future diagnosis, treatment, and prognostic evalua- tion of peripheral neuropathies.

关键词： nerve regeneration high-resolution ultrasound radial nerve cross-sectional area peripheral nerve nerve lesion neural regeneration

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Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study

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World Journal of Stem Cells 2024年第1期16卷 19-32页

作者： ErdinçCivelek Serdar Kabatas Eyüp Can Savrunlu Furkan Diren Necati Kaplan Demet Ofluoğlu Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery University of Health Sciences TurkeyGaziosmanpaşa Training and Research HospitalGaziosmanpaşa 34255IstanbulTurkey Center for Stem Cell&Gene Therapy Research and Practice University of Health Sciences TurkeyGaziosmanpaşa 34255IstanbulTurkey Department of Neurosurgery Nevşehir State HospitalNevşehir 50300Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalÇorlu 59860TekirdağTurkey Department of Physical Medicine and Rehabilitation Ofluoğlu KlinikGöztepe 34728IstanbulTurkey Liv Hospital Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell)Beşiktaş34340IstanbulTurkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineZeytinburnu 34010IstanbulTurkey Istinye University Center for Stem Cell and Tissue Engineering Research and PracticeBeşiktaş34340IstanbulTurkey

BACKGROUND Peripheral nerve injury can result in significant clinical complications that have uncertain ***,there is a lack of effective pharmacological interventions for nerve damage,despite the existence of several small compounds,Despite the objective of achieving full functional restoration by surgical intervention,the persistent challenge of inadequate functional recovery remains a significant concern in the context of peripheral nerve *** To examine the impact of exosomes on the process of functional recovery following a complete radial nerve *** A male individual,aged 24,who is right-hand dominant and an immigrant,arrived with an injury caused by a knife *** cut is located on the left arm,specifically below the *** neurological examination and electrodiagnostic testing reveal evidence of left radial nerve *** sural autograft was utilized for repair,followed by the application of 1 mL of mesenchymal stem cell-derived exosome,comprising 5 billion *** exosome was split into four equal volumes of 0.25 mL each and delivered microsurgically to both the proximal and distal stumps using the subepineural *** patient was subjected to a period of 180 d during which they had neurological examination and electrodiagnostic *** The duration of the patient’s follow-up period was 180 *** increasing Tinel’s sign and sensory-motor recovery were detected even at the 10th wk following nerve *** the conclusion of the 6-mo post-treatment period,an evaluation was conducted to measure the extent of improvement in motor and sensory functions of the *** assessment was based on the British Medical Research Council scale and the Mackinnon-Dellon *** results indicated that the level of improvement in motor function was classified as M5,denoting an excellent ***,the level of improvement in sensory function was classified as S3+,indicating a good *** is

关键词： Mesenchymal stem cell Exosomes radial nerve Sural nerve

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The radial nerve Entrapment in Pediatric Extension-Type Supracondylar Humeral Fractures. About Two Cases Reports

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Open Journal of Orthopedics 2016年第3期6卷 52-57页

作者： Amadou N. Kassé Malick Diallo Souleymane Diao Mohamed Tall Babacar Thiam Jean Claude F. Sané Mouhamadou H. Sy Hopital General de Grand Yoff of Dakar Dakar Sénégal CHU Yalgado Ouedraogo Ouagadougou Burkina Faso

radial nerve injuries in displaced extension-type supracondylar humeral fractures in children are well known. Entrapment in fracture of radial nerve is uncommon and rarely evocated in literature. We report two similar... 详细信息

关键词： Entrapment radial nerve Exploration Supracondylar Humeral Fractures

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An unusual cause of radial nerve palsy

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Chinese Journal of Traumatology 2014年第3期17卷 175-177页

作者： Hemendra Kumar Agrawal Vipin Khatkar Mohit Garg Balvinder Singh Ashish Jaiman Vinod Kumar Sharma Central Institute of Orthopedics VMMC andSafdarjung Hospital New Delhi 110029 India

Neurapraxia frequently occurs following traction injury to the nerve intraoperatively, leading to radial nerve palsy which usually recovers in 5-30 weeks. In our case, we had operated a distal one-third of humeral shaft fracture and fixed it with 4.5 mm limited contact dynamic compression plate. The distal neurovascular status of the limb was assessed postoperatively in the recovery room and was found to be intact and all the sensory-motor functions of the radial nerve were normal. On the second postoperative day, following the suction drain removal and dressing, patient developed immediate radial nerve palsy along with wrist drop. We reviewed the literature and found no obvious cause for the nerve palsy and concluded that it was due to traction injury to the radial nerve while removing the suction drain in negative pressure.

关键词： radial nerve Humeral fractures Paralysis Diaphyses

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Acupuncture plus TDP Treated 34 Cases of radial nerve Paralysis

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Journal of Acupuncture and Tuina Science 2003年第1期1卷 46-47页

作者： ZHANG Gui-xiang HUANG Guo-qi General Hospital of Tianjin Medical University Tianjin 300052 China

In the treatment of 34 cases of radial nerve paralysis by puncturing the acupoints in Yang-ming meridians of the hand and foot, plus TDP radiation in the local areas after acupuncture, the total effective rate is 97.1%. Key Words Acupuncture Therapy - radial nerve - Paralysis - TDP Author: Zhang Gui-xiang(1956-), male, attending physicianTranslator: Huang Guo-qi

关键词： Acupuncture Therapy radial nerve Paralysis TDP

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Combined radial and median nerve injury in diaphysea fracture of humerus： a case report

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Chinese Journal of Traumatology 2013年第6期16卷 365-367页

作者： Rajesh Rohilla Rohit Singla Narender Kumar Magu Roop Singh Ashish Devgun Reetadyuti Mukhopadhyay Paritosh Gogna Department of Orthopaedic Surgery Paraplegia & Re-habilitation PtBD Sharma PGIMS Rohtak 124001

radial nerve palsy is the most common neurological involvement in humeral shaft *** combined radial and median nerve injury in a closed diaphyseal fracture of the humerus is *** injury to both radial and median nerve can cause significant disability.A detailed clinical examination is therefore necessary following humeral shaft *** report a patient with closed diaphyseal humeral fracture （AO 12A-2.3） together with radial and median nerve palsy,its management and review of the *** the patient had two nerves involved,surgical exploration was *** was reduced and fixed with a 4.5 mm narrow dynamic compression pla *** was no external injury to both radial and median nerves on surgical *** recovery started at 3 weeks＇ *** recovery was seen at 12 *** clinical examination is of the utmost importance in early diagnosis of combined nerve injuries,which allows better management and rehabilitation of the patient.

关键词： Humeral fractures radial nerve Me-dian nerve Diaphyses Paralysis

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Evaluation of nerve transfer options for treating total brachial plexus avulsion injury： a retrospective study of 73 participants

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Neural Regeneration Research 2018年第3期13卷 470-476页

作者： Kai-ming Gao Jing-jing Hu Jie Lao Xin Zhao Department of Hand Surgery Huashan Hospital Fudan University Shanghai China Nursing Department Huashan Hospital Fudan University Shanghai China Key Laboratory of Hand Reconstruction Ministry of Health Shanghai China Shanghai Key Laboratory of Peripheral nerve and Microsurgery Shanghai China

Despite recent great progress in diagnosis and microsurgical repair, the prognosis in total brachial plexus-avulsion injury remains *** number of donors and unreasonable use of donor nerves might be key factors. To identify an optimal treatment strategy for this condition, we conducted a retrospective review. Seventy-three patients with total brachial plexus avulsion injury were followed up for an average of 7.3 years. Our analysis demonstrated no significant difference in elbow-flexion recovery between phrenic nerve-transfer （25 cases）, phrenic nerve-graft （19 cases）, intercostal nerve （17 cases）, or contralateral C7-transfer （12 cases） groups. Restoration of shoulder function was attempted through anterior accessory nerve （27 cases）, posterior accessory nerve （10 cases）, intercostal nerve （5 cases）, or accessory ＋ intercostal nerve transfer （31 cases）. Accessory nerve ＋ intercostal nerve transfer was the most effective method. A significantly greater amount of elbow extension was observed in patients with intercostal nerve transfer （25 cases） than in those with contralateral C7 transfer （10 cases）. Recovery of median nerve function was noticeably better for those who received entire contralateral C7 transfer （33 cases） than for those who received partial contralateral C7 transfer （40 cases）. Wrist and finger extension were reconstructed by intercostal nerve transfer （31 cases）. Overall, the recommended surgical treatment for total brachial plexus-avulsion injury is phrenic nerve transfer for elbow flexion, accessory nerve ＋ intercostal nerve transfer for shoulder function, intercostal nerves transfer for elbow extension, entire contralateral C7 transfer for median nerve function, and intercostal nerve transfer for finger extension. The trial was registered at *** （identifier： NCT03166033）.

关键词： nerve regeneration brachial plexus-avulsion injury nerve transfer phrenic nerve accessary nerve contralateral C7 nerve intercostal nerve shoulder function elbow function median nerve radial nerve neural regeneration

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nerve transfer helps repair brachial plexus injury by increasing cerebral cortical plasticity

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Neural Regeneration Research 2014年第23期9卷 2111-2114页

作者： Guixin Sun Zuopei Wu Xinhong Wang Xiaoxiao Tan Yudong Gu Department of Trauma Surgery East Hospital Tongji University School of Medicine Department of Physiology & Pathophysiology School of Basic Medical Sciences Fudan University Medical School of the University of Queensland Department of Hand Surgery Huashan Hospital Fudan University

In the treatment of brachial plexus injury, nerves that are functionally less important are transferred onto the distal ends of damaged crucial nerves to help recover neuromuscular function in the target region. For example, intercostal nerves are transferred onto axillary nerves, and accessory nerves are transferred onto suprascapular nerves, the phrenic nerve is transferred onto the musculocutaneous nerves, and the contralateral C7 nerve is transferred onto the median or radial nerves. nerve transfer has become a major method for reconstructing the brachial plexus after avulsion injury. Many experiments have shown that nerve transfers for treatment of brachial plexus injury can help reconstruct cerebral cortical function and increase cortical plasticity. In this review article, we summarize the recent progress in the use of diverse nerve transfer methods for the repair of brachial plexus injury, and we discuss the impact of nerve transfer on cerebral cortical plasticity after brachial plexus injury.

关键词： nerve regeneration brachial plexus injury nerve transfer cortical plasticity intercostal nerve phrenic nerve radial nerve cerebral functional reconstruction review neural regeneration

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Treatment of posterior interosseous nerve entrapment syndrome with ultrasound-guided hydrodissection:A case report

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World Journal of Clinical Cases 2023年第27期11卷 6624-6630页

作者： Lan-Hui Qin Wan Cao Fei-Tong Chen Qi-Bo Chen Xi-Xia Liu Department of Rehebalitation Medicine The People's Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Posterior interosseous nerve(PIN)entrapment syndrome is one of the causes of weakness and pain of the arm muscles,which is prone to missed diagnosis and misdiagnosis in clinic *** paper reports a case of PIN entrapment syndrome,with PIN injury indicated by *** ultrasound was applied to identify that the entrapment point was located at the inlet of the Frohse arch and the outlet of the supinator *** with ultrasound-guided nerve hydrodissection was performed on the entrapment point,which significantly improved the ***-guided nerve hydrodissection is an effective therapeutic method for PIN entrapment *** SUMMARY A male patient,35 years old,worked as an automobile *** felt slightly weak extension activity of his right fingers 2 years ago but sought no ***,the symptoms gradually became aggravated and led to finger drop,particularly severe in the right middle finger,accompanied by supination weakness of the right *** electrophysiological examination showed that the patient had partial PIN injury of the right *** ultrasound examination indicated PIN entrapment at the inlet of the Frohse arch and the outlet of the supinator ***,PIN entrapment syndrome was *** treatment with ultrasound-guided nerve hydrodissection around the entrapment point,the dorsiflexion weakness of the right hand was significantly improved compared with before *** Ultrasound-guided hydrodissection is efficacious for PIN entrapment syndrome,with high clinical value and great application prospects.

关键词： Ultrasound-guided injection nerve hydrodissection Posterior interosseous nerve entrapment syndrome radial nerve Case report

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