检索结果-南通市图书馆

Adipose Derived Stem Cell on the Regeneration of Irradiated Mandible of Adult Rabbit Submitted to Distraction Osteogenesis

引用

Journal of Pharmacy and Pharmacology 2018年第2期6卷 113-122页

作者： M. M. Soares H. Segreto A. Aloise L. M. Ferreira Department of Plastic Surgery Federal University of Sao Paulo Rua Napoleao de Barros Sao Paulo-SP 04024-900 Brazil

Purpose： To evaluate the effect of adipose derived mesenchymal stem cell （ADSC） on the regeneration of irradiated mandible submitted to distraction osteogenesis on adult rabbits. Methods： Ten adult rabbits.were selected and the dorsal fat was harvested for isolation, dissociation and culture of adipose derived adult mesenchymal stem cells. The mandibles were irradiated on a single dose of 20 Gy. After 30 days the animals underwent mandibular lengthening by distraction osteogenesis. After 10 mm of lengthening, the animals were distributed into two groups. Saline solution （1 mL） was injected the control group, and supplemented with ADSC, on the study group. After 4 weeks the mandibles were removed and evaluated by tomography and histomorphometric analysis. Histomorphometric was obtained and statistical analysis done by Mann-Withney test （p 〉 0.05）. Results： The tomography shows a significant improvement on the Hounsfield scale for lateral fibrovascular zone （114.5±9.7 control group to 148 ± 24, p = 0.0045） and central fibrovascular zone （37 ± 13.4 control group to 96 ±41.8 on study groupp = 0.0045）. The Histomorphometric analysis demonstrated an increase area of new bone formation. The mineralized area was of 61.2 ± 9.9% in the study group and 31.3 ± 10.6% in the control group （p = 0.0045） for the central fibrovascular zone, 79.± 9.1% in the study group and 39.1 ± 14.7 on control group for anterior fibrovascular zone （p = 0.0001） and 67.7± 12.9% in the study group and 38.4 ± 12.9% in control group for posterior fibrovascular zone （p = 0.0001）. Conclusions： The injection of adipose derived mesenchymal stem cell was effective to improve bone regeneration distraction callus on the irradiated mandible.

关键词： Stem cells bone regeneration osteogenesis distraction mandible rabbits.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Toxicity of Alum to Newzealand rabbits

引用

Journal of Pharmacy and Pharmacology 2016年第6期4卷 273-278页

作者： Medani, A. B. El Badwi, S. M. A. Amin, A. E. Department of Pharmacology and Toxicology The Nile College Khartoum Sudan. Dept. of Medicine Pharmacology and Toxicology P.O.Box11111 University of Khartoum Khartoum Sudan.

This study was considered to assess the risk of alum which is used in Sudan for drinking water treatment purposes for a long period without toxicity freedom records .Newzealand rabbits.were chosen for animal phase trials, divided into 3 groups. One group was the undosed controls. Test groups were given alum at dose rates of 1% and 20% respectively for two groups after an adaptation period. Clinical signs were observed together with postmortem and histopathological examinations. Chemical investigations included enzymatic, metabolic, electrolyte and hematological changes. The test rabbits.demonstrated low voice, inappitence, whitish salivation, watery diarrhea and recumbence followed by emphysematous, lungs, electrolyte imbalance, renal dysfunctions, stiff focal inflammation of the empty intestines and congested liver with white spots. The control group was normal .On atomic absorption only the lungs kept residual alum, while the livers washed- out the substance ,may be via bile .Alum -dosed rabbits.showed necrosis in the cortex and medulla of the kidney, emphysema in the lungs and necrosis in the hepatocytes. On evaluation of the above results, alum was considered to be toxic to Newzealand rabbits.at dose rates tried.

关键词： Toxicity alum Newzealand rabbits.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

家兔盲肠和阑尾淋巴管的研究

引用

Current Zoology 1986年第1期32卷 28-31+104页

作者：金美善赵集中白利赞杨镇洙延边医学院人体解剖教研室

用色素穿刺注入法、动脉内墨汁硝酸银水溶液注入法研究了家兔盲肠和阑尾淋巴管的起始、走向及所属淋巴结。盲肠和阑尾的毛细淋巴营均起始于固有膜,后依次穿过肠壁各层移行为系膜内淋巴管。后者经阑尾、盲肠淋巴结与肠系膜上淋巴结群中... 详细信息

用色素穿刺注入法、动脉内墨汁硝酸银水溶液注入法研究了家兔盲肠和阑尾淋巴管的起始、走向及所属淋巴结。盲肠和阑尾的毛细淋巴营均起始于固有膜,后依次穿过肠壁各层移行为系膜内淋巴管。后者经阑尾、盲肠淋巴结与肠系膜上淋巴结群中的相应淋巴结相联系。盲肠粘膜下层淋巴管内开始出现瓣膜;阑尾淋巴管瓣膜则在阑尾系膜缘内才出现。

关键词： Lymphangial study Cecum Appendix vermiformis rabbits.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A New Model of Drug-Disease Interaction in rabbits

引用

Journal of Pharmacy and Pharmacology 2017年第8期5卷 591-605页

作者： Sahar K. Hegazy Noha A. Hamdy Ahmed G. Adam Nawal M. Khalafallah Faculty of Pharmacy Tanta University Tanta Egypt Faculty of Pharmacy Pharos University Alexandria Egypt Faculty of Medicine Alexandria University Alexandria Egypt Faculty of Pharmacy Alexandria University Alexandria Egypt

Background： Drug-infection interaction should be considered in drug prescribing, particularly if potentiated byco-occuring drug-drug interactions. The effects of Candida and e-coli infections separately, and fluconazole administration weretested on cyclosporine blood level in rabbits. Methods： Three study designs were carried out, crossoversingle-dose-fluconazole-cyclosporine study testing fluconazole-cyclosporine interaction, multi-dosecandida-fluconazole-cyclosporine and multi-dose escherichia coli-cyclosporine study designs involving each rabbit acting as itscontrol; cyclosporine was given daily in both studies. Candida and e-coli infections were inoculated on day 5. In theMulti-Candida-Fluc-CyA, fluconazole-cyclosporine interaction was also considered, and flueonazole was administered daily fromday 9-18. In all three studies, Cyclosporine trough levels and serum creatinine were measured by CMIA and enzymatic assayrespectively, pre, during, post-infection and after fluconazole administration in the Candida study. Results： Both infections resulted insignificant rise in cyclosporine trough level （p = 0.018） and （p = 0.005） in fungal and bacterial studies, respectively. The median risein CyA level reached 52% （range 9-426%） in the Candida infection and reached 60 - 47.5% （mean） with the e-coli *** also increased mean cyclosporine trough levels in the single-dose study by 70.3 - 45.3 and the concomitant rise inthemulti-dose study reached 76% （median, range 22-665%）. Conclusions： Cyclosporine trough levels increased during Candida ande-coli infections and also during fluconazole administration in the single and multi-dose studies. Fluconazole exerted an additiveeffect to the Candida inhibitory effect. Type of infection and inoculum size affected CyA levels differently. Monitoring cyclosporinelevel during episodes of infection as well as in therapy regimen involving interacting drugs is advisable.

关键词： Candida, cyclosporine, CYP450, disease-interaction, e-coli, rabbits.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinico-pathological Studies in Experimental Eimeria Infection in Domestic rabbits.（Oryctolagus Cuniculus）

引用

Journal of Life Sciences 2010年第3期4卷 21-24页

作者： Asiya Magray Majidah Rashid Abdul Rashid Khan Post Graduate Department of Zoology the University of Kashmir Srinagar 190006 Kashmir India Department of Biochemistry Sherai-Kashmir Institute of Medical Sciences - Soura Srinagar 190007 Kashmir India

Clinico-pathological study of experimental Eimeria species infection （coccidiosis） such as E. magna, E. intestinalis, E. irresidua, E. media and E. perforans in rabbits.was conducted with dose inocula of 1 lac sporulated oocysts. These rabbits.were divided into two groups each consisting of 12 rabbits. Two rabbits.of infected untreated group died of severe disease on the 27^th ＆ 28^th day post infection. The intestine of dead animals showed elevated lesions in the middle half portion with congestion and destruction of villar epithelium.

关键词： Coccidiosis Eimeria intestinal kashmir rabbits.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：