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The Anticancer Potential of quassinoids-A Mini-Review

Engineering 2024年第7期38卷 27-38页

作者： Cai Lu Si-Nan Lu Di Di Wei-Wei Tao Lu Fan Jin-Ao Duan Ming Zhao Chun-Tao Che Jiangsu Collaborative Innovation Center of Chinese Medicinal Resource Industrialization Nanjing University of Chinese MedicineNanjing 210023China National and Local Collaborative Engineering Center of Chinese Medicinal Resource Industrialization and Formulae Innovative Medicine Nanjing University of Chinese MedicineNanjing 210023China School of Chinese Medicine&School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Department of Pharmaceutical Sciences College of PharmacyUniversity of Illinois ChicagoChicagoIL 60612USA

The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the *** from the potent cytotoxic and antitumor properties of these degraded triterpenes,several quassinoids have exhibited synergistic effects with anticancer *** article provides an overview of the potential anticancer properties of quassinoids,including their cytotoxic and antitumor activities,mechanisms of action,safety evaluation,and potential benefits in combination with anticancer drugs.

关键词： quassinoid Anticancer potential Antiproliferative mechanism Safety evaluation Synergistical combination with anticancer drugs

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Regioselective Synthesis and Biological Evaluation of 1-Hydroxyl Modified Ailanthinone Derivatives as Antimalarials

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Open Journal of Synthesis Theory and Applications 2013年第4期2卷 91-96页

作者： Mahendra D. Chordia William F. McCalmont Kirsten S. Smith Philip L. Smith Division of Experimental Therapeutics Walter Reed Army Institute of Research Silver Spring USA

The triterpene quassinoid ailanthinone is a structurally intricate natural product possessing highly potent antimalarial activity against multidrug resistance plasmodium parasites. Although the mechanism of action of ailanthinone is not completely understood, it is presumed to disrupt regular ribosomal functions by inhibiting parasite protein synthesis. Natural scarcity and low solubility of many quassinoids have impeded their development as potential clinical candidates, but exquisite potency of ailanthinone against Plasmodium remains compelling in the global fight against malaria. Herein, we report the highly selective synthesis of 1-hydroxyl derivatives of ailanthinone, including ester, carbonate, carbamate and sulfonate derivatives. The key feature of the synthesis is a one-step regioselective modification of the 1-hydroxyl group in favor of two other hydroxyl groups at C12 and C13. Derivatives were obtained via direct reaction with acyl/sulfonyl chlorides in the presence of a tertiary amine base without any protection-deprotection. In vitro antimalarial evaluations of these derivatives were compared with chloroquine and mefloquine against the Plasmodium falciparum clones, D6, W2, and TM91C235. The results demonstrate that modification of the 1-hydroxyl group is achievable, and the antimalarial activity of these derivatives relative to the parent product is significantly retained, thus paving the way for synthesis of derivatives with improved biological availability and/or increased potency.

关键词： Antimalarials Ailanthinone Triterpenoids quassinoid Plasmodium Falciparum Multidrug Resistance

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Nortriterpenoids from Order Rutales

Nortriterpenoids from Order Rutales

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13th Asian Chemical Congress

作者： FANG Xin~a DI Yingtong~a YAN Xiaohui~a CHEN Jia~a GENG Zhaoliang~a YIN Jun-lin~a HE Hongping ~a HAO Xiaojiang~(a*) State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of Botany Chinese Academy of Sciences Kunming 650204 P.R.China

＜正＞Specifically,the nomenclature nortriterpenoids refer to the degraded triterpenoids mainly found in order *** group is further divided into two biosynthetically related types,namely limonoids and quassinoids,and they have showed diverse biological activities such as antitumor,antimalarial, antiviral,anti-inflammatory,antifeedant ***,we have investigated the

关键词： Limonoid quassinoid Antifeedant Anti-TMV Synergistic Effects

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Chemical study on the antiviral constituents from roots of Ailanthus altissima Swingle

Chemical study on the antiviral constituents from roots of A...

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药用植物化学与中药有效成分分析研讨会

作者： Qing-wei Tan~2,Zu-jian Wu~(1*),Ming-an Ouyang~(1,2),Lian-hui Xie~1 1 Institute of Plant Virology,Fujian Agriculture and Forestry University,Fuzhou,Fujian,350002,P.R.China 2 Key Laboratory of Bio-pesticide and Chemistry-Biology,Ministry of Education,Fujian Agriculture and Forestry University, Fuzhou,Fujian,350002,P.R.China

Twelve known compounds,including three quassinoids,along with seven neolignans,two aromatic compounds were obtained from the roots of Ailanthus altissima *** structures of these compounds were determined based on spectra and chemical *** assay among six of these constituents showed,a quassinoid(cpd 8) possessed a significant activity in inhibiting infection and replication of tobacco mosaic virus(TMV).This is the first report concerning the anti-phytoviral activity of this traditional medical plant.

关键词： Ailanthus altissima Swingle quassinoid neolignan antiviral TMV

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