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Protein folding as a quantum transition between conformational states

Frontiers of physics 2011年第1期6卷 133-140页

作者：罗辽复 Laboratory of Theoretical Biophysics Faculty of Physical Science and Technology Inner Mongolia University Hohhot 010021 China

Assuming that the main variables in the life processes at the molecular level are the conforma- tion of biological macromolecules and their frontier electrons a formalism of quantum theory on conformation-electron system is proposed. Based on the quantum theory of conformation-electron system, the protein folding is regarded as a quantum transition between torsion states on polypep- tide chain, and the folding rate is calculated by nonadiabatic operator method. The rate calculation is generalized to the case of frequency variation in folding. An analytical form of protein folding rate formula is obtained, which can be served as a useful tool for further studying protein folding. The application of the rate theory to explain the protein folding experiments is briefly summarized. It includes the inertial moment dependence of folding rate, the unified description of two-state and multistate protein folding, the relationship of folding and unfolding rates versus denaturant concen- tration, the distinction between exergonic and endergonic foldings, the ultrafast and the downhill folding viewed from quantum folding theory, and, finally, the temperature dependence of folding rate and the interpretation of its non-Arrhenius behaviors. All these studies support the view that the protein folding is essentially a quantum transition between conformational states.

关键词： protein folding rate quantum transition torsion states non-Arrhenius temperaturedependence exergonic and endergonic folding ultrafast folding

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quantum conformational transition in biological macromolecule

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 143-158页

作者： Liaofu Luo Jun Lv School of Physical Science and Technology Inner Mongolia University Hohhot 010021 China Center for Physics Experiment College of Science Inner Mongolia University of Technology Hohhot 010051 China

Background： Recently we proposed a quantum theory on the conformational change of biomolecule, deduced several equations on protein folding rate from the first principles and discussed the experimental tests of the theory. The article is a review of these works. Methods： Based on the general equation of the conformation-transitional rate several theoretical results are deduced and compared with experimental data through bioinformatics methods. Results： The temperature dependence and the denaturant concentration dependence of the protein folding rate are deduced and compared with experimental data. The quantitative relation between protein folding rate and torsional mode number （or chain length） is deduced and the obtained formula can be applied to RNA folding as well. The quantum transition theory of two-state protein is successfully generalized to multi-state protein folding. Then, how to make direct experimental tests on the quantum property of the conformational transition of biomolecule is discussed, which includes the study of protein photo-folding and the observation of the fluctuation of the fluorescence intensity emitted from the protein folding/unfolding event. Finally, the potential applications of the present quantum folding theory to molecular biological problems are sketched in two examples： the glucose transport across membrane and the induced pluripotency in stem cell. Conclusions： The above results show that the quantum mechanics provides a unifying and logically simple theoretical starting point in studying the conformational change of biological macromoleeules. The far-reachlng results in practical application of the theory are expected.

关键词： conformational change quantum transition protein folding RNA folding temperature dependence

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Multi-ion cooperative processes in Yb^(3+) clusters

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Light(Science & Applications) 2014年第1期3卷 123-128页

作者： Wei-Ping Qin Zhen-Yu Liu Chol-Nam Sin Chang-Feng Wu Guan-Shi Qin Zhe Chen Ke-Zhi Zheng State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Cooperative luminescence(CL)occurs in spectral regions in which single ions do not have energy *** was first observed more than 40 years ago,and all results reported so far are from a pair of *** this work,upconverted CL of three Yb^(3+) ions was observed in the ultraviolet(UV)region under near-infrared(NIR)*** UV CL intensity showed a cubic dependence on the NIR pump power,whereas the luminescence lifetime was nearly one-third the luminescence lifetime of single Yb^(3+) *** triplet CL(TCL)has a clear spectral structure,in which most emission peaks are consistent with the self-convoluted spectra from single Yb^(3+) *** shifts were observed for certain peaks,indicating complex interactions among the excited Yb^(3+) *** probability of the TCL process versus the average distances among three Yb^(3+) ions was derived via the first-and second-order corrections to the wave functions of lanthanide ions,indicating that the formation of Yb^(3+) clusters containing closely spaced ions favors the occurrence of the multi-ion interaction ***,the cooperative sensitization of one Gd^(3+) ion by four excited Yb^(3+) ions(Yb^(3+)-tetramer)was demonstrated experimentally,which exhibited a novel upconversion mechanism—cluster *** results are intriguing for further exploring quantum transitions that simultaneously involve multiple ions.

关键词： cooperative luminescence cooperative sensitization quantum transition ytterbium cluster

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