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Effects of physical exercise on the quality-of-life of patients with haematological malignancies and thrombocytopenia:A systematic review and meta-analysis

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World Journal of Clinical Cases 2022年第10期10卷 3143-3155页

作者： Yu-Pei Yang Shuang-Jun Pan Shu-Lin Qiu Tao-Hsin Tung Department of Hematology Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Department of Neurosurgery Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen 518055Guangdong ProvinceChina Evidence-Based Medicine Center Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

BACKGROUND Annually,there are an estimated 1187000 new patients worldwide diagnosed with haematological malignancies.Effective strategies are needed to alleviate side effects and prevent the physical and psychosocial degeneration of patients in active treatment for haematological malignancies.AIM To explore the effects of physical exercise on quality of life(Qo L)of patients with haematological malignancies and thrombocytopenia.METHODS Cochrane Library,Pub Med and Embase were searched for all relevant articles reporting randomized controlled trials(RCTs)that were published up to 31 July 2021.Two authors independently selected articles in accordance with the inclusion criteria,evaluated their quality,and collected information.Any controversy was resolved through discussion with a third senior author.The PRISMA 2009 checklist was followed.RESULTS Seven RCTs were selected in the systematic review and three were included in the final meta-analysis.There were significant differences in Qo L between physical exercise groups[mean score difference=8.81;95%confidence interval(CI):1.81-15.81,P=0.01],especially in emotional functioning(mean score difference=12.34;95%CI:4.64-20.04,P=0.002)and pain(mean score difference=–12.77;95%CI:-3.91 to-21.63,P=0.005).CONCLUSION Physical exercise has clinical effects on Qo L and improves emotional function and pain indices of patients with haematological malignancies and thrombocytopenia.

关键词： Haematological malignancies Thrombocytopenia Exercise quality-of-life Systematic review Meta-analysis

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Oncological results, functional outcomes and health-related quality-of-life in men who received a radical prostatectomy or external beam radiation therapy for localized prostate cancer： a study on long-term patient outcome with risk stratification

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Asian Journal of Andrology 2009年第3期11卷 283-290页

作者： Itsuhiro Takizawa Noboru Hara Tsutomu Nishiyama Masaaki Kaneko Tatsuhiko Hoshii Emiko Tsuchida Kota Takahashi Division of Urology Department of Regenerative and Sciences Niigata University Niigata 951-8510 Japan Transplant Medicine Graduate School of Medical and Dental Division of Radiation Oncology Department of Molecular Genetics Graduate School of Medical and Dental Sciences Niigata University Niigata 951-8510 Japan

Health-related quality-of-life （HRQOL） after a radical prostatectomy （RP） or extemal beam radiation therapy （EBRT） has not been studied in conjunction with oncological outcomes in relation to disease risk stratification. Moreover, the long-term outcomes of these treatment approaches have not been studied. We retrospectively analyzed oncological outcomes between consecutive patients receiving RP （n = 86） and EBRT （n = 76） for localized prostate cancer. HRQOL and functional outcomes could be assessed in 62 RP （79%） and 54 EBRT （79%） patients over a 3-year follow-up period （median： 41 months） using the Medical Outcomes Study Short Form-36 （SF-36） and the University of Califomia Los Angeles Prostate Cancer Index （UCLA PCI）. The 5-year biochemical progression-free survival did not differ between the RP and EBRT groups for low-risk （74.6% vs. 75.0%, P = 0.931） and intermediate-risk （61.3% vs. 71.1%, P = 0.691） patients. For high-risk patients, progression-free survival was lower in the RP group （45.1%） than in the EBRT group （79.7%）（P = 0.002）. The general HRQOL was comparable between the two groups. Regarding functional outcomes, the RP group reported lower scores on urinary function and less urinary bother and sexual bother than the EBRT group （P 〈 0.001, P 〈 0.05 and P 〈 0.001, respectively）. With risk stratification, the low- and intermediate-risk patients in the RP group reported poorer urinary function than patients in the EBRT group （P 〈 0.001 for each）. The sexual function of the high-risk patients in the EBRT group was better than that of the same risk RP patients （P 〈 0.001）. Biochemical recurrence was not associated with the UCLA PCI score in either group. In conclusion, low- to intermediate-risk patients treated with an RP may report relatively decreased urinary function during long-term follow-up. The patient＇s HRQOL after treatment did not depend on biochemical recurrence.

关键词： long-term observation quality-of-life radiation therapy radical prostatectomy risk stratification

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Androgen-deprivation therapy alone versus combined with radiation therapy or chemotherapy For nonlocalized prostate cancer： a systematic review and meta-analysis

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Asian Journal of Andrology 2016年第1期18卷 102-107页

作者： Jun-Hao Lei Liang-Ren Liu Qiang Wei Tu-Run Song Lu Yang Yang Meng Ping Han Department of Urology West China Hospital Sichuan University Guoxue Xiang #37 Chengdu 610041 Sichuan China

In this paper, we reviewed the long-term survival outcomes, safety, and quality-of-life of androgen-deprivation therapy （ADT） alone versus combined with radiation therapy （RT） or chemotherapy for locally advanced and metastatic prostate cancer （PCa）. A literature search was performed using OvidSP. Randomized controlled trials （RCTs） that met the following criteria were included： including locally advanced or metastatic PCa, comparing ADT alone versus combined with any treatment method and reporting quantitative data of disease control or survival outcomes. Finally, eight RCTs met the inclusion criteria. Among these, three compared ADT versus ADT plus RT （n = 2344） and one compared ADT versus ADT plus docetaxel-estramustine （n = 413） in locally advanced PCa; two compared ADT versus ADT plus docetaxel （n = 1175） and two compared ADT versus ADT plus estramustine （n = 114） in metastatic PCa. For locally advanced PCa, the addition of RT to long-term ADT can improve the outcomes of survival and tumor control with fully acceptable adverse effects. Specially, the pooled odds ratio （OR） of overall survival （OS） was 1.43 （95% confidence interval 1.20-1.71） when compared ADT plus RT with ADT alone （P 〈 0.0001）. For metastatic hormonally sensitive PCa, the concurrent use of docetaxel plus ADT was effective and safe （pooled OR of OS： 1.29 [1.01-1.65]： P = 0.04）. In all, long-term ADT plus RT and long-term ADT plus docetaxel should be considered as proper treatment option in locally advanced and metastatic hormonally sensitive PCa, respectively. The major limitation for the paper was that only eight RCTs were available.

关键词： androgen-deprivation chemotherapy prostate cancer quality-of-life radiation therapy

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Development and predictive validity of the cirrhosis-associated ascites symptom scale: A cohort study of 103 patients

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World Journal of Gastroenterology 2018年第15期24卷 1650-1657页

作者： Agnete Nordheim Riedel Nina Kimer Anne-Sofie Houlberg Jensen Emilie Kristine Dahl Mads Israelsen Luise Aamann Lise Lotte Gluud Gastro Unit Medical Davison Copenhagen University Hospital Hvidovre Abdominal Center K Medical Section Copenhagen University Hospital Bispebjerg Department of Gastroenterology and Hepatology University Hospital Zealand Slagelse Department of Gastroenterology and Hepatology Odense University Hospital Department of Hepatology and Gastroenterology Aarhus University Hospital

AIM To develop a scale of domains associated with the health-related quality-of-life(HRQOL) in patients with cirrhosis-related ascites.METHODS We initially undertook literature searches and a qualitative study in order to design a cirrhosis-associated ascites symptom(CAS) scale describing symptoms with a potential detrimental impact on health related quality of life(HRQL)(the higher the score, the worse the symptoms). Discriminatory validity was assessed in a validation cohort including cirrhotic patients with(1) tense/severe;(2) moderate/mild; or(3) no ascites(controls). Patients also completed chronic liver disease questionnaire(CLDQ) and the Euro QoL 5-Dimensions 5-Level(EQ-5D-5L) questionnaire evaluating HRQL. The relation between scale scores was analysed using Spearman correlations. RESULTS The final CAS scale included 14 items. The equivalent reliability was high(Chronbach's alpha 0.88). The validation cohort included 103 patients(72% men, mean age 62.4 years). The mean scores for each question in the CAS scale were higher for patients with severe/tense ascites than for mild/moderate ascites and controls. Compared with controls(mean = 9.9 points), the total CAS scale score was higher for severe/tense ascites(mean = 23.8 points) as well as moderate/mild ascites(mean = 18.6 points)(P < 0.001 both groups). We found a strong correlation between the total CAS and CLDQ score(rho = 0.82, P < 0.001) and a moderate correlation between the CAS and the EQ-5D-5L score(0.67, P < 0.001). CONCLUSION The CAS is a valid tool, which reflects HRQOL in patients with ascites.

关键词： Health-related quality-of-life Cirrhosis Symptom burden Symptom assessment

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Effect of testosterone replacement treatment on constitutional and sexual symptoms in type 2 diabetic men. need for rules

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Asian Journal of Andrology 2015年第2期17卷 217-218页

作者： Fotios Dimitriadis Nikolaos Sofikitis Department of Urology University of Ioannina Medical School Ioannina Greece.

In a recent publication, Gianatti and colleagues investigated the effect of testosterone treatment in obese, aging men with type 2 diabetes （T2D） with mild to moderate symptoms, a modest reduction in testosterone levels, mild to moderate aging male symptoms, and erectile dysfunction？ The authors could not show any significant improvement in constitutional or sexual symptoms in this group of men. This randomized double-blind, parallel, and placebo-controlled trial among other critically emphasizes the increased testosterone prescriptions worldwide and together with other corroborating or contradictory studies awakes the need for guidelines in the androgen replacement treatment.

关键词： quality-of-life DEPRESSIVE SYMPTOMS ANDROGEN DEFICIENCY METABOLIC SYNDROME HYPOGONADAL MEN ADULT MEN THERAPY METAANALYSIS UNDECANOATE DYSFUNCTION

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Direct anterior approach vs Hardinge in obese and nonobese osteoarthritic patients:A randomized controlled trial

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World Journal of Orthopedics 2021年第11期12卷 877-890页

作者： George Macheras Sophia Stasi Michail Sarantis Athanasios Triantafyllou Dimitrios Tzefronis Stamatios A Papadakis 4^(th) Orthopaedic Department “KAT”General Hospital of AtticaAthens 14561KifissiaGreece Laboratory of Neuromuscular and Cardiovascular Study of Motion(LANECASM) Physiotherapy DepartmentUniversity of West AtticaAthens 12243EgaleoGreece 2^(nd) Orthopaedic Department “KAT”General Hospital of AtticaAthens 14561KifissiaGreece

BACKGROUND The increased prevalence of obesity has resulted in orthopedic surgeons being likely to face many patients with a high body mass index(BMI)who warrant total hip arthroplasties(THAs)over the coming years.Studies'findings considered the postoperative clinical,and functional outcomes in these patients are controversial,and selecting the most appropriate surgical approach remains debatable.AIM To compare pain-levels,functionality,and quality-of-life in obese and nonobese osteoarthritic patients who have undergone primary total hip arthroplasty through either direct-anterior-approach(DAA)or Hardinge-approach.METHODS One hundred and twenty participants(>50 years)were divided into four groups according to the surgical approach(DAA or Hardinge)and patients'BMI(nonobesequality-of-life was evaluated with the 12-item-International Hip Outcome Tool-Greek version(iHOT12-Gr)(Clinical Trial Identifier:ISRCTN15066737).RESULTS DAA vs Hardinge:(week 6)DAA-patients showed 12.2% less pain,more functionality(14.8% shorter TUG-performance time,21.5% higher MHHS-Gr),and 38.16% better quality-of-life(iHOT12-Gr)compared to Hardinge-patients(all P valuesquality-of-life,compared to the Hardinge-groups.The DAA benefited obese and

关键词： Total hip arthroplasty Osteoarthritis Obesity Pain Functional ability quality-of-life

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The opportunity cost of androgen suppression in locally advanced prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 356-357页

作者： Phillip J Gray Jason A Efstathiou William U Shipley Harvard Radiation Oncology Program Boston MA 02114 USA Department of Radiation Oncology Massachusetts General Hospital Boston MA 02114 USA

The use of androgen suppression ther- apy （AST） and radiotherapy for locallyadvanced prostate cancer has become the standard of care worldwide. At the same time, it has become clear that AST carries significant risk for side effects. Recently, Denham and colleagues have reported ini- tial quality of life （QoL） results from the TROG 03.04 RADAR trial. The authors identify clinically meaningful decrements in patient-reported QoL for those treated with 18 months of AST vs. 6 months but only marginal differences at 36 months. Once survival data becomes available, these data will help to frame any benefits seen for longer courses of AST.

关键词： PHASE-III TRIAL quality-of-life DEPRIVATION THERAPY CARDIOVASCULAR MORTALITY RADIATION-THERAPY RANDOMIZED-TRIAL RADIOTHERAPY DURATION

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