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Energy Metabolism Disorder and Myocardial Injury in Chronic Myocardial Ischemia with qi deficiency and blood stasis syndrome Based on 2-DE Proteomics

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Chinese Journal of Integrative Medicine 2013年第8期19卷 616-620页

作者： Yong Wang 王勇 (11230) Wen-jing Chuo 啜文静 (11230) Chun Li 李春 (11230) Shu-zhen Guo 郭淑贞 (11230) Jian-xin Chen 陈建新 (11230) Jun-da Yu 余俊达 (11230) Wei Wang 王伟 (11230) 11230. Beijing University of Chinese Medicine Beijing 100029 China

Objective： To inquire the characteristic proteins in chronic myocardial ischemia by testing twodimensional electrophoresis （2-DE） map to explore the possible inherent pathological mechanism and the therapeutic intervention of qi deficiency and blood stasis syndrome. Methods： Ameroid constrictor ring was placed on the first interval of left anterior descending coronary artery to prepare chronic myocardial ischemia model on Chinese miniature swine. Animals were randomly divided into sham group and model group with 10 animals in each group, respectively. The dynamic symptoms observation of the four diagnostic information was collected from 0 to 12 weeks. Echocardiography was employed to evaluate cardiac function and the degree of myocardial ischemia, 2-DE and matrix-assisted laser desorption/ionization-time of flight mass spectrometry （MALDI-TOF-MS） were used to carry out proteomics research on animals. Enzyme-linked immunosorbent assay was applied to identify the relevant differential proteins on chronic myocardial ischemia with qi deficiency and blood stasis syndrome. Results： The preliminary study found that at the 12th week, chronic myocardial ischemia with qi deficiency and blood stasis syndrome model was established stably. Compared with the sham group, there were 8 different proteins down-regulated, 22 proteins up-regulated significantly. After validated by MALDI- TOF-MS/MS, 11 protein spots were identified. Distinct proteins were mainly associated with energy metabolism and myocardial structural injury, including isocitrate dehydrogenase 3 （NAD＋） alpha, NADH dehydrogenase （NAD） Fe-S protein 1, chain A （crystal structure of aidose reductase by binding domain reveals a new Nadph）, heat shock protein 27 （HSP27）, oxidoreductase （NAD-binding protein）, antioxidant protein isoform, cardiac troponin T （cTnT）, myosin （myosin light polypeptide）, cardiac alpha tropomyosin, apolipoprotein A- I and albumin. Conclusion： Down-regulated energy metabolism disorder mediated by N

关键词： chronic myocardial ischemia Chinese medicine qi deficiency and blood stasis syndrome proteomics

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Serum proteomic approach in patients with qi deficiency and blood stasis syndrome in coronary heart disease:to explore therapeutic mechanism of Yiqi Huoxue decoction

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中国药理学与毒理学杂志 2021年第10期35卷 734-734页

作者： LI Ying WANG Zhi-bo ZHU Ming-jun WANG Yong-xia MA Bo MIAO Lan PAN Ying-hong LIU Jian-xun Beijing Key Laboratory of Pharmacology of Chinese Materia Region National Clinical Research Center for Chinese Medicine CardiologyXiyuan HospitalChina Academy of Chinese Medical Sciences.Beijing 100091China The First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450011China Institute of Crop Science Chinese Academy of Agricultural SciencesBeijing 100081China

OBJECTIVE To explore the curative effect and mechanism of Yiqi Huoxue decoction in the treatment of coronary heart disease with qi deficiency and blood stasis *** The patients with coronary heart disease of qi deficiency and blood stasis syndrome were treated with Yiqi Huoxue decoction for 3 months,and the changes of cardiac function were observed.61 serum samples(including 29 cases of disease group and 32 cases of Yiqi Huoxue expression group)were analyzed by non labeled *** disease group was used as the control group,and the protein with expression level difference of more than 1.2 folds(Pqi Huoxue decoction in the treatment of coronary heart disease with qi deficiency and blood stasis *** Clinical treatment found that Yiqi Huoxue decoction can improve TCM syndrome score and left ventricular ejection fraction,regulate blood glucose and blood lipid levels,prolong thrombin time,and improve heart *** results of proteomic quantitative analysis showed that there were 69 proteins with different expression levels in the disease *** analysis results showed that Yiqi Huoxue decoction may regulate ApoA1,alpha-2 and other proteins to act on HDL assembly,platelet degradation,PI3K Akt signaling pathway,and then play a therapeutic role in coronary heart disease with qi deficiency and blood stasis *** Yiqi Huoxue decoction can effectively improved the heart function decline caused by qi deficiency and blood stasis syndrome of coronary heart *** mainly act on energy metabolism and platelet activation pathway by activating HDL assembly and platelet degradation signal pathway *** study can provide reference for the follow-up treatment mechanism of qi deficiency and blood stasis syndrome o

关键词： qi deficiency and blood stasis syndrome coronary heart disease Yiqi Huoxue decoction proteomic

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Serum Low-Density Lipoprotein and Heart Rate Related to the Effectiveness in the Treatment of Angina Pectoris with Two Similar Chinese Medicine Herbal Formulae

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Chinese Journal of Integrative Medicine 2011年第12期17卷 903-907页

作者： YAN Shi-yan yAO chen DING Xiao-rong JIANG Miao LU Ai-ping Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Beijing （100700） China Peking University First Hospital Beijing （100034） China E-Institute of Shanghai Municipal Education Commission Shanghai University of Traditional Chinese Medicine Shanghai （201203） China

Objective： To explore the effectiveness related indicators which might help identify the indications of Tongxinluo Capsule （通心络胶囊） and Kangxin Capsule （康欣胶囊） targeting on qi deficiency and blood stasis pattern in Chinese medicine （CM） in the treatment of angina pectoris. Methods： The data from a multicenter, randomized and double-blinded study conducted at 5 centers in China were obtained for the analysis. A total of 239 patients with angina pectoris and CM syndrome of qi deficiency and blood stasis were randomly assigned in a 1：1 ratio to Tongxinluo Capsule group （119 cases） and Kangxin Capsule group （120 cases）. Angina effectiveness and electrocardiogram （ECG） improvement were selected as the therapeutic outcomes. Results： After a 4-week treatment, the effective rates of Tongxinluo Capsule and Kangxin Capsule were 43.70% and 25.00%, respectively （P〈0.05）. Serum low-density lipoprotein （LDL） level was found to influence the effectiveness of Tongxinluo Capsule which had higher effective rate in the patients with lower level of LDL. Heart rate was found to influence the effectiveness in the patients treated with Kangxin Capsule which had higher effective rate in the patients with heart rate ≤80 beats/min. Conclusion： LDL level and heart rate were the indicators which help indentify the indications of Tongxinluo Capsule and Kangxin Capsule, respectively, in the treatment of angina pectoris with CM syndrome of qi deficiency and blood stasis.

关键词： angina pectoris qi deficiency and blood stasis syndrome Chinese medicine low-densitylipoprotein heart rate

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