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Cardiac protection of new compounds from scientific Chinese medicine (SCM)

Cardiac protection of new compounds from scientific Chinese ...

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两岸三地药理学与临床药理学术会议

作者： ZHU Yi-zhun (Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 200032, China)

Objective Purification and Standardization of Chinese herbal extracts became a hot topic since last *** traditional Chinese medicine(TCM)has been used as a mixture from several herbs for cen- turies,it has been drawn much attention for studying the standardized Chinese herbs using modern technolo- *** Recently,we compared purified salvia miltiorrhiza extract(PSME)with angiotensin-con- verting enzyme inhibitor,Ramipril,in in vitro experiments and also in vivo using animal model of myocar- dial *** PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free *** could also prevent pyrogalto red bleach- ing and DNA *** 2 weeks treatment with PSME or Ramipril,survival rates of rats with experi- mental myocardial infarction were marginally increased(68.2% and 71.4%)compared with saline (61.5%).In another recent study,we evaluated the cardioprotective effects of PSME on myocardial is- chemia/reperfusion injury in isolated rat hearts and in hypoxic vascular smooth muscle *** found that PSME treated hearts showed significant postischemic contractile function recovery(develop pressure recov- ered to 44.2±4.9% versus 17.1±5.7%,P<0.05;maximum contraction recovered to 57.2±5.9% ver- sus 15.1±6.3%,P<0.001;maximum relaxation restored to 69.3±7.3% versus 15.4±6.3%,P<0.001 in PSME and control group respectively).Conclusions Significant elevated in end-diastolic pressure, which indicated LV stiffening in PSME hearts might be resulted by exceed dose of PSME *** and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.

关键词： traditional Chinese medicine purified salvia miltiorrhiza extract myocardial infarction ramipril

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