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Adhesion molecule and proinflammatory cytokine gene expression in hepatic sinusoidal endothelial cells following cecal ligation and puncture

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World Journal of Gastroenterology 2001年第1期7卷 128-130页

作者： Rong Qian Wu Ying Xin Xu Xu Hua Song Li Jun Chen Xian Jun Meng Institute of Surgical Research, General Hospital of PLA, Beijing 100853, China Institute of surgical Research General Hospital of PLA Beijing 100853 China.

INTRODUCTIONMultiple organ dysfunction syndrome (MODS) isthought to be a frequent consequence of sepsis[1-3].Despite substantial advances in our knowledge and understanding of the basic pathophysiologic mechanisms[4-7... 详细信息

关键词： Animals Cecum Cytokines Endothelium Gene Expression Intercellular Adhesion Molecule-1 Interleukin-1 Interleukin-6 Ligation Liver Mice punctures RNA, Messenger Research Support, Non-U.S. Gov't Sepsis Tumor Necrosis Factor-alpha Vascular Cell Adhesion Molecule-1

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Efficacy of Shenfu decoction on sepsis in rats with condition induced by cecal ligation and puncture

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Journal of Traditional Chinese Medicine 2020年第4期40卷 621-628页

作者： Liu Jin Liu Fusheng Liang Tengxiao Cao Po Li Jing Zhang Yin Liu Yang Department of Emergency Dong Zhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Department of Emergency Dong Fang Hospital Beijing University of Chinese MedicineBeijing 100078China Department of Nephropathy and Endocrinology Dong Zhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China Center for Integrated Chinese and Western Medicine Beijing You An hospitalcapital medical universityBeijing 100069China

OBJECTIVE:To evaluate the efficacy of Shenfu decoction(SFD)prepared with a traditional Chinese formula,on sepsis in rats with the condition induced by cecal ligation and puncture(CLP),and to study the possible mechanism underlying its ***:Forty clean-grade male Sprague-Dawley rats were divided randomly into three groups:normal control group(NCG,n=10),model control group(MCG,n=15)and Shenfu decoction group(SFDG,n=15).Sham-operated rats in NCG were served as operation control,while rats in both MCG and SFDG were exposed to CLP,a procedure to develop experimental *** in SFDG were administered with SFD by gavage(3 mg/g of body weight,twice a day)2 h prior to CLP and directly after successful CLP,while rats in NCG and MCG were gavaged with equivalent volume of sterilized *** in all groups were starved with free access to *** 24 h of administration,the mortality of rats in each group was *** indicators of inflammatory response[the peritoneal inflammation by Simon's method Classification as well as serum concentrations of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)by enzyme linked immunosorbent assay(ELISA)]in survival rats were *** indicators of gut barrier[The intestinal mucosal injury index,serum concentrations of D-lactic acid and secretory IgA(sIgA)in intestinal mucosa by ELISA,as well as gut microbiota by16S rRNA gene sequencing]in survival rats were ***:The mortality(20%)of rats in SFDG was lower than that(33.3%)of the MCG(P<0.01).The mortality(20%)of rats in SFDG was lower than that(33.3%)of the MCG(χ2=6.533,P=0.011).Compared with the MCG,the peritoneal inflammation as well as serum concentrations of TNF-αand IL-6 decreased significantly in SFDG(all P<0.01).Compared with the MCG,the IMII,serum concentrations of D-lactic acid,sIgA in intestinal mucosa were alleviated by SFD treatment(all P<0.01).Increase in levels of Proteobacteria and reduction levels of Bacteroidetes induced by sepsis wer

关键词： Sepsis punctures Inflammation Shenfu decoction Gut barrier

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Bloodletting puncture in the treatment of acute ischemic stroke:protocol for a mixed-method study of a multi-center randomized controlled trial and focus group

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Journal of Traditional Chinese Medicine 2023年第6期43卷 1259-1267页

作者： DAI Zeqi LIAO Xing GUAN Yueyue ZENG Zixiu TANG Jun HU Jing Center for Evidence Based Chinese Medicine Institute of Basic Research in Clinical MedicineChina Academy of Chinese Medical SciencesBeijing 100700China Department of Encephalopathy Chongqing Hospital of Traditional Chinese MedicineChongqing 400021China Evidence-based Medicine Center Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing Institute of Traditional Chinese MedicineBeijing 100010China

This study is to investigate the effectiveness and safety of bloodletting puncture(BP)for acute ischemic stroke(AIS)when used in combination with standard treatment,as well as the patients'feelings and attitudes toward the *** is a mixed method research which includes a multi-center,superiority,randomized controlled clinical trial,and focus group interview.A total of 360 AIS participants will be *** will be randomized into one of the following two groups for 7 d:(a)BP with standard treatment group(n=180);(b)standard treatment group(n=180).The primary outcome will be National Institute of Health stroke scale(NIHSS)score at day 7 after *** outcomes will be changes of Glasgow Coma Scale score,NIHSS score,mRS and Traditional Chinese Medicine syndrome score from baseline to 7,14,and 30 d after treatment,recurrence rate and all-cause mortality rate within 30 d,and the safety *** focus group will be conducted with a purposive sample of 1-2 acupuncturists and 1-2 patients respectively at each center at 7 and 30 d after *** designed a mixed method study to evaluate the effect of BP,an acupuncture therapy for patients with *** the findings of this study confirm the effectiveness of BP to reduce the NIHSS score and other related outcomes and patients are willing to accept the therapy,we believe this study will help the implementation of this therapy in clinical practice,and provide new evidence for the treatment of AIS.

关键词： bloodletting punctures ischemic stroke equivalence trial randomized controlled trial focus groups clinical protocols

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Rapid hemostasis of the residual inguinal access sites during endovascular procedures:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12684-12689页

作者： Hyangkyoung Kim Kwangjin Lee Sungsin Cho Jin Hyun Joh Department of Vascular Surgery Kyung Hee University Hospital at GangdongSeoul 05278South Korea Department of Surgery Kyung Hee University Hospital at GangdongSeoul 05278South Korea

BACKGROUND In endovascular procedures including total percutaneous endovascular aneurysm repair(pEVAR),percutaneous access through the common femoral artery is most commonly ***-site bleeding is a major concern in percutaneous ***,we present a case of successful control of continuous oozing using a vascular closure device(VCD)and the application of Surgicel(Johnson&Johnson,United States)over the access *** SUMMARY An 82-year-old man presented with an unruptured abdominal aortic aneurysm measuring 83 mm×75 *** patient had a medical history of atrial fibrillation and was receiving rivaroxaban(15 mg/d).Routine pEVAR was performed using the preclose technique with ProGlide(Abbott,Santa Clara,CA,United States).Significant amount of bleeding was observed at the end of the procedure after the deployment of the closure device at the access site.A sheet of Surgicel was applied to the suture thread using a surgical *** was applied to the surface of the artery along the access tract using a pusher,and hemostasis was immediately *** This simple technique is an excellent adjunct to control residual bleeding from the access site following VCD use.

关键词： Endovascular procedures punctures Hemostasis Hemostatic techniques Femoral artery Case report

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Management of Post-Dural Puncture Headache Using Autologous Epidural Blood Patch in a Patient with Acute Lymphoblastic Leukemia

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Open Journal of Anesthesiology 2017年第4期7卷 83-87页

作者： John Narron Mohamed Farrag Elbert Mets Saif Mahmoud Khaled Sedeek Hershey Medical Center Pennsylvania State University Hershey PA USA Cornell University Ithaca NY USA

We report a case of a patient in remission of acute lymphoblastic leukemia (ALL) with severe positional headaches that required an epidural blood patch (EBP) despite the higher risks of infection and introduction of blast cells to the epidural space. A 43-year-old male with a history of ALL presented with persistent positional headache after multiple intrathecal punctures. Despite initial improvement with medical treatment and bed rest, severe positional headache [consistent with post-dural puncture headache] constantly agonized the patient. EBP was performed after discussion of all of the medical teams involved. Following the procedure, the patient experienced immediate pain relief. EBP is very effective in the management of post-dural puncture headache (PDPH). Still there is risk of introducing infectious and/or malignant cells into the central nervous system. Alternatively, there are agents available that could be employed other than a patient’s own blood.

关键词： Acute Lymphoblastic Leukemia Intrathecal punctures CSF Leakage Positional Headaches Epidural Blood Patch Autologous Blood

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Tie2 mRNA in peripheral blood： a new marker to assess damage of endothelial cells in a rat model of sepsis

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Chinese Journal of Traumatology 2010年第5期13卷 308-312页

作者：杨京黄健张耀宗陈林 State Key Laboratory of Trauma Burns and Combined Injury Trauma Center Trauma Laboratory Institute of Sur- gery Research Daping Hospital Third Military Medical University. Chonaaina 400042 China Intensive Care Unit Institute of Surgery Research Daping Hospital Third Military Medical University Chongqing 400042 China

Objective： To evaluate the endothelial cell damage by detecting the circulating Tie2 mRNA level in a rat model of sepsis. Methods： The model of sepsis was established by cecal ligation and puncture （CLP） in 90 rats which were divided into 6 groups： normal, sham, CLP-3 h, CLP-6 h, CLP- 12 h and CLP-24 h. Serum biochemical markers were detected by automatic biochemical analyzer. Serum IL-6 was measured with enzyme linked immunosorbent assay. The vascular permeability of liver, kidney, lung and heart was detected with Evans blue. Circulating endothelial cells （CEC） were separated using density gradient separation and counted. Total RNA of whole blood were extracted and the mRNA levels of two endothelial specific genes, Tie2 and vascular endothelial growth factor receptor 2 （VEGFR2）, were measured by quantitative real-time PCR. Results： The level of serum biochemical indexes increased after CLP. The amount of serum IL-6 in CLP-6 h, 12 h,and 24 h group was increased 6.5-fold （P〈 0.05）, 8.4-fold （P〈 0.01 ）, and 13.3-fold （P〈0.001 ） compared with normal group （ 170.68 pg/mli42.46 pg/ml） respectively （F= 14.319, P〈0.001）. Significantly increased organ vasopermeability of liver, kidney, lung and heart was observed after CLP respectively. The number of CEC peaked （11.83±1.94） 3 hours after CLP compared with normal control （5.33±1.21, P〈0.05）, and then decreased gradually （F=54.183, P〈0.001）. The mRNA level of Tie2 in CLP-3 h group （3.47±1.47） was also markedly higher than that in other groups （F=10.640, P〈0.001 ）. Conclusion： Using quantitative real-time PCR to measure the level of Tie2 mRNA in peripheral blood is a simple and relatively sensitive method to evaluate the damage of endothelial cells.

关键词： Endothelial cells Polymerase chainreaction Sepsis Ligation punctures

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