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Enhancing bioactivity and stability of polymer-based materialtissue interface through coupling multiscale interfacial interactions with atomic-thin TiO2 nanosheets

引用

Nano Research 2023年第4期16卷 5247-5255页

作者： Rongchen Xu Xiaodan Mu Zunhan Hu Chongzhi Jia Zhenyu Yang Zhongliang Yang Yiping Fan Xiaoyu Wang Yuefeng Wu Xiaotong Lu Jihua Chen Guolei Xiang Hongbo Li Department of Stomatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Stomatology The Third Medical CenterChinese PLA General HospitalBeijing 100039China Department of Stomatology Kunming Medical UniversityKunming 650500China National Clinical Research Center for Oral Diseases&Shaanxi Key Laboratory of Stomatology Department of ProsthodonticsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Department of Stomatology The Strategic Support Force Medical CenterBeijing 100101China State Key Laboratory of Chemical Resource Engineering College of ChemistryBeijing University of Chemical TechnologyBeijing 100029China

Stable and bioactive material-tissue interface(MTF)basically determines the clinical applications of biomaterials in wound healing,sustained drug release,and tissue *** many inorganic nanomaterials have been widely explored to enhance the stability and bioactivity of polymer-based biomaterials,most are still restricted by their stability and *** we demonstrate the enhanced bioactivity and stability of polymer-matrix bio-composite through coupling multiscale material-tissue interfacial interactions with atomically thin TiO_(2)*** modified with TiO_(2)nanosheets displays improved mechanical properties,hydrophilicity,and ***,we confirm that this resin can effectively stimulate the adhesion,proliferation,and differentiation into osteogenic and odontogenic lineages of human dental pulp stem cells using in vitro cell-resin interface ***_(2)nanosheets can also enhance the interaction between demineralized dentinal collagen and *** results suggest an approach to effectively up-regulate the stability and bioactivity of MTFs by designing biocompatible materials at the sub-nanoscale.

关键词： material-tissue interface TiO_(2)nanosheets pulpo-dentinal complex biomaterial resin composite

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