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Animal models of pulmonary hypertension due to left heart disease

Animal Models and Experimental Medicine 2022年第3期5卷 197-206页

作者： Shao-Fei Liu Yi Yan Charité-Universitätsmedizin Berlin Corporate Member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlinGermany DZHK(German Centre for Cardiovascular Research) Partner Site BerlinBerlinGermany Institute for Cardiovascular Prevention(IPEK) Ludwig-Maximilians-University MunichMunichGermany DZHK(German Centre for Cardiovascular Research) Partner Site Munich Heart AllianceMunichGermany

pulmonary hypertension due to left heart disease(PH-LHD) is regarded as the most prevalent form of pulmonary hypertension(PH). Indeed, PH is an independent risk factor and predicts adverse prognosis for patients with left heart disease(LHD). Clinically, there are no drugs or treatments that directly address PH-LHD, and treatment of LHD alone will not also ameliorate PH. To target the underlying physiopathological alterations of PH-LHD and to develop novel therapeutic approaches for this population, animal models that simulate the pathophysiology of PH-LHD are required. There are several available models for PH-LHD that have been successfully employed in rodents or large animals by artificially provoking an elevated pressure load on the left heart, which by transduction elicits an escalated pressure in pulmonary artery. In addition, metabolic derangement combined with aortic banding or vascular endothelial growth factor receptor antagonist is also currently applied to reproduce the phenotype of PH-LHD. As of today, none of the animal models exactly recapitulates the condition of patients with PH-LHD. Nevertheless, the selection of an appropriate animal model is essential in basic and translational studies of PH-LHD. Therefore, this review will summarize the characteristics of each PH-LHD animal model and discuss the advantages and limitations of the different models.

关键词： animal model l eft ventricular failure metabolic syndrome pulmonary hypertension due to left heart disease pulmonary vascular remodeling

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