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Protection of Total Flavonoid Fraction from Nervilia fordii on Lipopolysaccharide-induced Acute Lung Injury in Rats

Chinese Herbal Medicines 2012年第4期4卷 287-293页

作者： HUANG Ming-qing XIE You-liang LAI Xiao-ping LIN Ling XU Yin-ji LU Jin-jian CHEN Xiu-ping College of Pharmacy Fujian University of Traditional Chinese MedicineFuzhou 350108China Institute of Drug Research and Development Guangzhou University of Chinese MedicineGuangzhou 510405China Guangdong Provincial Hospital of Traditiona lChinese Medicine Guangzhou 510120China State Key Laboratory of Quality Rese arch in Chinese Medicine University of MacaoMacao 999078China

Objective To investigate the effects of total flavonoid fraction(TFF) from Nervilia fordii on lipopolysaccharide(LPS)-induced acute lung injury(ALI) in rats,and to explore their protective *** LPS-induced ALI model was established by LPS(5 mg/kg) injection via left cervical *** samples were collected from the cervical artery of all rats at 5 and 6 h after LPS challenge for arterial blood gas test and cytokines measurements,and pulmonary microvascular permeability(PMP),lung wet/dry weight ratio(W/D),and pathological features were *** Phytochemical study showed that the TFF contained 67.3% of flavonoids expressed in rutin and three flavone *** TFF pretreatment(6.24 and 12.48 mg/kg) attenuated the partial arterial pressure of oxygen decline in blood significantly,and decreased the PMP and lung W/D in ALI *** addition,the TFF(6.24 and 12.48 mg/kg) also ameliorated the LPS-induced lung damages including alveolar edema,neutrophils infiltration,alveolar hemorrhage,and thickening of the alveolar ***,the treatment with the TFF(6.24 and 12.48 mg/kg) also down-regulated the levels of pro-inflammatory cytokines,such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and intercellular adhesion molecule-1(ICAM-1),and up-regulated the level of anti-inflammatory cytokine IL-10 in serum of ALI rats *** These results suggest that the TFF could protect LPS-induced ALI in rats,which may be mediated,at least in part,by adjusting the production of inflammatory cytokines including TNF-α,IL-6,ICAM-1,and IL-10.

关键词： acute lung injury cytokine Nervilia fordii pulmonary microvascular permeability total flavonoid fraction

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