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Monitoring film coalescence from aqueous polymeric dispersions using atomic force microscopy: Surface topographic and nano-adhesion studies

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Asian Journal of Pharmaceutical Sciences 2020年第1期15卷 104-111页

作者： Ziyi Yang Duncan QMCraig School of Pharmaceutical Science Jiangnan University1800 Lihu RoadWuxi 214122China UCL School of Pharmacy 29-39 Brunswick SquareLondon WC1N1AXUK

The aim of the investigation was to develop the use of topographic and nano-adhesion atomic force microscopy(AFM) studies as a means of monitoring the coalescence of latex particles within films produced from a pharmaceutically relevant aqueous dispersion(Eudragit~?NE30 D). Films were prepared via spin coating and analysed using AFM, initially via tapping mode for topographic assessment followed by force-distance measurements which allowed assessment of site-specific adhesion. The results showed that colloidal particles were clearly observed topographically in freshly prepared samples, with coalescence detected on curing via the disappearance of discernible surface features and a decrease in roughness indices. The effects of temperature and humidity on film curing were also studied, with the former having the most pronounced effect. AFM force measurements showed that the variation in adhesive force reduced with increasing curing time, suggesting a novel method of quantifying the rate of film formation upon curing. It was concluded that the AFM methods outlined in this study may be used as a means of qualitatively and quantitatively monitoring the curing of pharmaceutical films as a function of time and other variables, thereby facilitating rational design of curing protocols.

关键词： Film curing Atomic force microscopy Spin coating Aqueous dispersion AFM pull-off force measurement

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The Liquid-Bridge with Large Gap in Micro Structural Systems

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Journal of Modern Physics 2011年第5期2卷 404-415页

作者： Shiqiao Gao Lei Jin Jingqing Du Haipeng Liu 不详

Based on the analysis of the total free energy of the liquid-bridge, several methods are presented to analyze the pull-off force of liquid-bridge. For the liquid bridge system with a large gap width, accurate solutions of a two-plates liquid bridge and a sphere-plane liquid bridge are given. In addition, the edge-effect resulting from the profile of the top solid in the liquid-bridge system is analyzed and calculated. It is proved by the subsequent tests.

关键词： Liquid-Bridge MEMS Capillary pull-off Force

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