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Treatment of congenital ptosis

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Annals of Eye Science 2020年第4期5卷 57-69页

作者： Vladimir Kratky Department of Ophthalmology Queen’s UniversityKingstonCanada st Medical Faculty Charles UniversityPragueCzech Republic

Congenital ptosis is an abnormally low position of the upper eyelid,with respect to the visual axis in the primary *** can be present at birth or manifest itself during the first year of life and can be bilateral or ***,it may be an isolated finding or part of a constellation of signs of a specific syndrome or systemic *** on how much it interferes with the visual axis,it may be considered as a functional or a cosmetic *** childhood,functional ptosis can lead to deprivation amblyopia and astigmatism and needs to be ***,even mild ptosis with normal vision can lead to psychosocial problems and correction is also advised,albeit on a less urgent ***,patching and glasses can be prescribed to treat the amblyopia,the mainstay of management is *** are several types of surgical procedure available depending on the severity and etiology of the droopy *** first part of this paper will review the different categories of congenital ptosis,including more common associated *** latter part will briefly cover the different surgical approaches,with emphasis on how to choose the correct *** spite of many complex factors inherent to the treatment of congenital ptosis,the overall outcomes are quite satisfactory,and most surgeons feel that ptosis management can be both challenging and rewarding at the same time.

关键词： Congenital ptosis ptosis review

The "central six" of ptosis repair: eliminating contour as a variable in external levator surgery

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Plastic and Aesthetic Research 2020年第3期7卷 17-22页

作者： Benjamin C.Campbell Susuana T.Adjei William R.Nunery H.B.Harold Lee Oculofacial Plastic and Orbital Surgery IndianapolisIN 46280USA Ascension St.Vincent Hospital IndianapolisIN 46260USA Department of Ophthalmology Indiana University School of MedicineIndianapolisIN 46290USA.

Aim:Eyelid contour is a key component to satisfactory lid position and appearance following ptosis repair,the components of which have been highly debated and remain difficult to objectively *** sought to minimize the number of intraoperative adjustments required and reduce reoperation rates by addressing only the central 6 mm of tarsus when reapproximating levator to the anterior surface of tarsus,thereby eliminating contour as an adjustable ***:All patients who underwent external levator resection with blepharoplasty for correction of involutional ptosis between 2012 and 2019 by a single surgeon at one center were retrospectively *** who underwent concomitant brow lifting surgery were *** same technique was used for each eyelid with uniform suture *** 6-0 silk horizontal mattress suture was placed partial thickness through the superior third of tarsus 3 mm lateral to the center of tarsus;another was passed 3 mm medial to the center of *** sutures were placed outside of this central 6-mm *** fixation was used to determine lid height and *** satisfactory,the sutures were tied down in a permanent fashion and the eyelid position again *** total,153 eyelids in 85 patients were *** obtained included preoperative and postoperative margin-to-reflex distance(MRD1),intraoperative and postoperative complications,reoperation rates,and patient satisfaction with appearance of lid contour and ***:The mean follow up time was 3.41 *** mean preoperative MRD1 was 1.05 *** mean post-operative was 3.18 *** patients had recovery of an anatomically normal temporal peak *** of 153 ;eyelids(1.31%)required reoperation due to residual ptosis or *** patients had postoperative ***-one percent of patients who underwent bilateral surgery had satisfactory symmetry defined as less than or equal to 1-mm difference between right and left MR

关键词： ptosis levator advancement central 6

Treatment of mild and moderate congenital ptosis via the levator imbrication technique

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第4期5卷 173-177页

作者： Feixue Ding Xuran Zhu Li Yang Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai 200011China Department of Plastic and Aesthetic Surgery Second Affiliated Hospital Zhengzhou UniversityZhengzhou 450014China

Background:To correct mild and moderate congenital ptosis,traditional surgical techniques usually include dissection of the Müller’s ***,both the levator palpebrae superioris and the Müller’s muscle play a synergistic role to elevate the upper ***,to protect the Müller muscle and minimize injury,we developed and applied a levator imbrication technique in patients with mild and moderate congenital ptosis and followed it up to evaluate its clinical ***:This retrospective case series included 53 patients with mild and moderate congenital ptosis,all of whom had undergone ptosis correction using the levator imbrication technique at the Plastic and Aesthetic Department of the Second Affiliated Hospital of Zhengzhou University between June 2018 and June *** outcomes of correction,upper eyelid appearance,and operative complications were observed and *** postoperative follow-up was 3–12 ***:Fifty cases of ptosis were fully corrected,and the bilateral double eyelids were smooth and *** eyelids of 20 patients were incompletely closed immediately after the operation but were able to close spontaneously within 2 *** serious complications such as exposure keratitis were *** patients with undercorrection underwent reoperation 3 months after the first operation,and ptosis was ***:The levator imbrication technique for mild and moderate congenital ptosis is simple to perform and shortens the operation time with less damage,stable postoperative outcomes,and no long-term complications.

关键词： ptosis Levator Imbricate suture

Recommendation on data collection and annotation of ocular appearance images in ptosis

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Intelligent Medicine 2023年第4期3卷 287-292页

作者： Jie Meng Binying Lin Dongmei Li Shiqi Hui Xuanwei Liang Xianchai Lin Zhen Mao Xingyi Li Zuohong Li Rongxin Chen Yahan Yang Ruiyang Li Anqi Yan Haotian Lin Danping Huang Chinese Association of Artificial Intelligence,Medical Artificial IntelligenceBranch of Guangdong Medical Association Zhongshan Ophthalmic Center Sun Yat-sen UniversityState Key Laboratory of OphthalmologyGuangzhouGuangdong 510080China Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedicalArtificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital MedicalUniversityBeijing 100730China Zhongshan School of Medicine Sun Yat-sen UniversityGuangzhouGuangdong 510080China

ptosis is a common ophthalmologic condition,and the diagnosis is primarily based on ocular *** of such conditions can be improved using emerging technology such as artificial ***,unified data collection and labeling standards have not yet been *** directlyimpacts the accuracy of ptosis diagnosis based on appearance ***,in the present study,we aimedto establish a procedure to obtain and label images to devise a recommendation system for optimal recognitionof ptosis based on ocular *** would help to standardize and facilitate data sharing and serve as aguideline for the development and improvisation of algorithms in artificial intelligence for ptosis.

关键词： ptosis Ocular appearance image Annotation standard Artificial intelligence

X-Linked Dominant Congenital ptosis Cosegregating with an Interstitial Insertion of a Chromosome 1p21.3 Fragment into a Quasipalindromic Sequence in Xq27.1

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Open Journal of Genetics 2014年第6期4卷 415-425页

作者： David J. Bunyan David O. Robinson Anthony G. Tyers Shuwen Huang Vivienne K. Maloney Francis H. Grand Sarah Ennis Samantha R. de Silva John A. Crolla Tristan F. W. McMullan Wessex Regional Genetics Laboratory Salisbury District Hospital Salisbury UK Human Genetics Division Southampton University School of Medicine Southampton UK Ophthalmology Department Salisbury District Hospital Salisbury UK Manchester Centre for Genomic Medicine Saint Mary’s Hospital Manchester UK Genetic Epidemiology and Genomic Informatics Group Faculty of Medicine University of SouthamptonSouthampton UK Oxford Eye Hospital John Radcliffe Hospital Oxford UK Ophthalmology Department Northampton General Hospital Northampton UK

Blepharoptosis (ptosis) is defined as the abnormal drooping of the upper eyelid and is a feature of many conditions. It can be in isolated or syndromic form, bilateral or unilateral and congenital or acquired. Previously we have carried out linkage analysis on a family with dominantly inherited congenital bilateral isolated ptosis and found the condition to be linked to a region of approximately 20 megabases of chromosome Xq24-Xq27.1 with a cumulative LOD score of 5.89. We now describe further analysis using array comparative genomic hybridisation (array CGH), fluorescence in situ hybridisation (FISH), long range PCR and sequencing. This has enabled us to identify and characterise at the level of DNA sequence an insertional duplication and rearrangement involving chromosomes 1p21.3 and a small quasipalindromic sequence in Xq27.1, disruption of which has been associated with other phenotypes but which is cosegregating with X-linked congenital bilateral isolated ptosis in this family. This work highlights the significance of the small quasipalindromic sequence in genomic rearrangements involving Xq27.1 and the importance of comprehensive molecular and molecular cytogenetic investigations to fully characterise genomic structural complexity.

关键词： ptosis X-Linked Dominant Insertional Duplication

Unilateral ptosis in a Child with Wilm’s Tumor Induced by Vincristine

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Journal of Cancer Therapy 2022年第12期13卷 649-653页

作者： Aziza El Ouali Karim Lahrache Zohair El Haddar Ayad Ghannam Abdeladim Babakhouya Maria Rkain Noufissa Benajiba Department of Pediatrics Mohammed VI University Hospital Center of Oujda Oujda Morocco

Vincristine is a chemotherapy drug belonging to the group of Vinca alkaloids which also includes vinblastine and vindesine. It is used in hematological malignancies and solid tumors. The Vinca alkaloids are neurotoxic, usually causing peripheral neuropathy, and rarely cranial neuropathies. We report a case of a 33-month-old male child diagnosed with Wilms’ tumor, who had an isolated unilateral right ptosis following vincristine, with a good improvement after stopping it.

关键词： Wilms’ Tumor Vincristine Neuropathy ptosis

Evaluation of the Levator Palpebrae Superioris Muscle Plication in the Treatment of ptosis (About 12 Cases)

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Open Journal of Ophthalmology 2019年第3期9卷 125-133页

作者： Aziz El Ouafi Adil Bouzidi Fatine El Alami Said Iferkhass Abdelkader Laktaoui Mohammed Moumine Ophthalmology Service Moulay Ismail Military Hospital Meknes Morocco

Introduction: The ptosis is a fall of the upper eyelid in relation to a deficit of the levator device of this one. In practice, it poses two major problems, the first one is the eminent risk of amblyopia during severe congenital ptosis, and the second is of an aesthetic nature, representing the main reason for consultation. The aim of this work is to evaluate the interest of the levator palpebrae superioris muscle plication in the ptosis surgery. Materials and Methods: We collected 12 patients who received a correction of their ptosis by plication of the levator palpebrae superioris muscle over a period of 3 years from January 2012 to December 2014. Result: The mean age at treatment was 22 years;the ptosis was congenital in 8 cases, and acquired in 4. The ptosis was major in 67% and moderate in 33% of the cases. Muscle plication was the basic surgical technique in all patients in our series. The function and aesthetic results were satisfying in 6 cases (50%), good in 4 cases (34%), acceptable in 1 case and bad in 1 case (8%). Discussion: The comparative study has shown that the plication of the levator palpebrae superioris muscle is a possible alternative for the correction of ptosis whatever the type of ptosis with results comparable to the reference technique compared to the degree of correction, whereas the operative follow-up is simpler and more minor complications. Conclusion: The surgical treatment of ptosis should be done after a systematic clinical examination and after very precise indications. However, the plication of the levator muscle of the upper eyelid has shown its functional and aesthetic efficiency in congenital ptosis and in the ptosis of the adult.

关键词： Congenital ptosis Acquired ptosis Placation of the Levator Palpebrae Superioris Muscle

Heterozygous Deletion on Chromosome 2p21 Causes a Newly Recognized Syndrome Comprising Conductive Hearing Loss and ptosis in Humans

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Heterozygous Deletion on Chromosome 2p21 Causes a Newly Reco...

The Effect of Vault on Conjunctiva Combined with Fascia Sheath Suspension on the Mobility and Aesthetics of Eyelid in Patients with ptosis

第十四次全国医学遗传学学术会议

作者：关静王大勇赵亚丽张锋张玉军兰兰李娜袁虎王秋菊解放军总医院解放军医学院耳鼻咽喉头颈外科解放军耳鼻咽喉研究所复旦大学生命科学学院

Objective:To report clinical characterization and identify molecular cytogenetic characterization of a newly syndrome for conductive hearing loss with ptosis in an autosomal dominant inheritance ***:Clinical evaluation,audiological and ophthalmic evaluation,high-resolution assay of comparative genomic hybridization microarray and genome-wide CNV analyses were ***:All the nine affected family subjects were identified as conductive deafness and bilateral congenital ptosis in a four-generation Chinese family with 24 members segregating in autosomal dominant *** did not find any associate phenotypes noted in *** heterozygous deletion on chromosome 2p21 discovered in each affected family subjects,spanning approximate 60kb in size,caused the loss of one copy in this ***:The features found in the Chinese affected family subjects indicate they have a newly recognized syndrome comprising conductive hearing loss and *** phenotypes could be attributed to heterozygous deletion on chromosome 2p21.

关键词： Heterozygous deletion Chromosome 2p21 Conductive hearing loss ptosis Autosomal dominant inheritance

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Proceedings of Anticancer Research 2020年第4期4卷 9-12页

作者： Liang Gao Shuang Xu Jun Liu Wei Luo Jing Chen Chengdu Wuhou Chinese Medical Union Liyuan Meidcal Cosm etology Outpatient Department Co. Ltd.Chengdu 610000Sichuan ProvinceChina

Objective:To investigate the effect of vault on conjunctiva combined with fascia sheath suspension on the mobility and aesthetics of eyelid in patients with ***:A total of 80 patients with ptosis who were admitted to our hospital from January 2017 to January 2019 were selected as the *** were divided into 2 groups with random number table method,40 cases *** control group was treated with modified single-incision frontalis fascia flap suspension,and the observation group was treated with vault on conjunctiva combined with fascia sheath *** eyelid margin activity,aesthetics and complications were compared between the two ***:The eyelid margin activity of the observation group after treatment was higher than that of the control group,the difference was statistically significant(Pptosis are treated with superior conjunctival fornix combined with fascia sheath suspension,which can improve the mobility of eyelid margin,and it is more beautiful and has less complications.

关键词： ptosis vault on conjunctiva combined with fascia sheath suspension Eyelid mobility Aesthetics