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Brain organoids are new tool for drug screening of neurological diseases

Neural Regeneration Research 2023年第9期18卷 1884-1889页

作者： Jin-Qi Zhou Ling-Hui Zeng Chen-Tao Li Da-Hong He Hao-Duo Zhao Yan-Nan Xu Zi-Tian Jin Chong Gao School of Medicine Institute of Brain and Cognitive ScienceHangzhou City UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of MedicineHangzhou City UniversityHangzhouZhejiang ProvinceChina

At the level of in vitro drug screening,the development of a phenotypic analysis system with highcontent screening at the core provides a strong platform to support high-throughput drug *** are few systematic reports on brain organoids,as a new three-dimensional in vitro model,in terms of model stability,key phenotypic fingerprint,and drug screening schemes,and particula rly rega rding the development of screening strategies for massive numbers of traditional Chinese medicine *** paper reviews the development of brain organoids and the advantages of brain organoids over induced neurons or cells in simulated *** paper also highlights the prospects from model stability,induction criteria of brain organoids,and the screening schemes of brain organoids based on the characteristics of brain organoids and the application and development of a high-content screening system.

关键词： brain organoids disease modeling high-content system multiple omic analysis network pharmacology neurodegeneration phenotypic fingerprint psychiatric diseases stem cells traditional Chinese medicine drug screening

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Triggering of Major Brain Disorders by Protons and ATP:The Role of ASICs and P2X Receptors

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Neuroscience Bulletin 2023年第5期39卷 845-862页

作者： Andri Cherninskyi Maksim Storozhuk Oleksandr Maximyuk Vyacheslav Kulyk Oleg Krishtal Bogomoletz Institute of Physiology of National Academy of Sciences of Ukraine Kyiv 01024Ukraine

Adenosine triphosphate(ATP)is well-known as a universal source of energy in living *** known is that this molecule has a variety of important signaling func-tions:it activates a variety of specific metabotropic(P2Y)and ionotropic(P2X)receptors in neuronal and non-neu-ronal cell ***,a wide variety of signaling func-tions well fits the ubiquitous presence of ATP in the *** more ubiquitous are *** from the unspe-cific interaction of protons with any protein,many physi-ological processes are affected by protons acting on specific ionotropic receptors--acid-sensing ion channels(ASICs).Both protons(acidification)and ATP are locally elevated in various pathological *** these fundamentally important molecules as agonists,ASICs and P2X receptors signal a variety of major brain *** we briefly outline the physiological roles of ASICs and P2X receptors,focusing on the brain pathologies involving these receptors.

关键词： ASICs P2X receptors Stroke Chronic pain Epilepsy Neurodegenerative psychiatric diseases

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Immune activation during neonatal exacerbates phencyclidine-induced behavioral phenotypes in adult mice

Immune activation during neonatal exacerbates phencyclidine-...

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国际药理学术研讨会暨第三届两岸三地药理学学术会议

作者： Yukihiro Noda Akihiro Mouri Hirotaka Hida Yu Ando Kiyofumi Yamada Toshitaka Nabeshima Division of Clinical Sciences and Neuropsychopharmacology Meijo University Graduate School of Pharmaceutical Sciences Department of Neuropsychopharmacology and Hospital Pharmacy Nagoya University Graduate School of Medicine Department of Chemical Pharmacology Meijo University Graduate School of Pharmaceutical Sciences

＜正＞Aim:Viral infection during neurodevelopment is involved in the etiology of psychiatric diseases including *** is a high prevalence of substance use disorder in first-episode *** examined whether the combination of a neonatal viral infection with an adolescent substance use affect on psychological function in ***:We subjected behavioral tests to

关键词： Viral infection Neonatal Neurodevelopment Phencyclidine Behaviors psychiatric diseases

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