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International Journal of Ophthalmology(English edition) 2015年第2期8卷 332-336页

作者： Mehmet Cuneyt Ozmen Zeynep Aktas Burcin Kepez Yildiz Murat Hasanreisoglu Berati Hasanreisoglu Department of Ophthalmology Gazi University Medical School

AIM: To compare retinal artery-vein diameters(RAVDs)of patients with pseudoexfoliation(PSX) syndrome with healthy controls and investigate the correlations between retinal nerve fiber layer(RNFL) thickness parameters and ***: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All participants underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera(Topcon 501X).RAVDs were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal,temporal and average RNFL thicknesses were *** and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation ***: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group(P =0.009, P =0.038,respectively). No statistically significant difference regarding RAVDs was found between two ***: RAVDs seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and RAVDs show significant correlations in both groups. This correlation doesn’t seem to be specific to PSX.

关键词： pseudoexfoliation retinal nerve fiber layer thickness retinal artery-vein diameters

Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma

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International Journal of Ophthalmology(English edition) 2016年第8期9卷 1138-1142页

作者： Tatjana S.Sarenac Vulovic Sladjana M.Pavlovic Vladimir LJ.Jakovljevic Katarina B.Janicijevic Nemanja S.Zdravkovic Department of Ophthalmology Clinical Center Kragujevac Center for Molecular Medicine and Stem Cell Research Faculty of Medical Sciences University of Kragujevac Department of Physiology Faculty of Medical SciencesUniversity of Kragujevac Faculty of Medical Sciences University of Kragujevac

AIMTo establish the role of nitric oxide (NO), ascorbic acid and tumour necrosis factor-α (TNF-α) in the pathogenesis of pseudoexfoliation glaucoma (XFG).METHODSOur study included 120 patients who were referred for cataract surgery. All patients were divided into four groups according to clinical findings: XFG, early and late pseudoexfoliation syndrome (XFS), and cataract (without pseudoexfoliation). Serum and aqueous humour levels of the ascorbic acid, NO and TNF-α were measured. The concentrations of the ascorbic acid and NO were measured by an appropriate spectrophotometric method. Enzyme-linked immunosorbent assay (ELISA) was used to determine TNF-α *** humour concentration of ascorbic acid was significantly lower in patients with late XFS (0.61±0.11 mmol/L) and XFG (0.48±0.15 mmol/L) compared to patients with early XFS (0.9±0.15 mmol/L) and cataract (1.16±0.22 mmol/L), while there was no difference in serum concentration in all examined groups. Aqueous humour concentration of NO was significantly higher in patients with XFG (77.7±11.4 µmol/L) compared to patients with early XFS (50.27±9.34 µmol/L) and cataract (49.77±7.1 µmol/L), while serum concentration was increased in the early stage of XFS (73.26±8.29 µmol/L). Aqueous humour level of proinflammatory cytokine TNF-α was increased in patients with XFS (early 460.04±18.32 pg/mL; late 502.42±53.23 pg/mL) and XFG (510.34±43.07 pg/mL), while there was no difference in serum level in all examined groups of *** ascorbic acid and elevated NO and inflammation related cytokine TNF-α level in aqueous humour of the patients with developed XFG suggest that oxidative stress induces local inflammation.

关键词： ascorbic acid nitric oxide pseudoexfoliation tumour necrosis factor alpha

Sensory-neural hearing loss in pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 393-396页

作者： Vafa Samarai Reza Samarei Negar Haghighi Elnaz Jalili Department of Ophthalmology Imam khomeni HospitalUrmia University of Medical sciencesUrmiaIran Department of Otolaryngology Imam khomeni HospitalUrmia University of Medical sciencesUrmiaIran Medical Student of Urmia University of Medical Sciences UrmiaIran Urmia Blood Transfusion Organization UrmiaIran

AIM:To evaluate relationship between ocular pseudoex-foliation syndrom(PXF) and sensory-neural hearing loss(SNHL).· METHODS:This prospective case-control study was designed on patients who referred to a general ophthalmic clinic at Imam Khomeini Medical Center,Urmia,Iran(March 2010 through November 2010).On routine ophthalmic examination,patients diagnosed with ocular PXF were referred to the ENT department and,selected cases(after evaluating inclusion and exclusion criteria) were referred to Audiometric *** tone hearing threshold level(HTL) was measured at 1,2,3 kHz for each ear and was compared with International Standard(ISO 7029) median age associated hearing loss at 1,2,3 kHz(AAHL).· RESULTS:Overall 21 of 50 patients(42.0%) had a higher HTL than the ISO 7029 median AAHL at 1,2 and 3kHz,which included 14 ears of 23 patients in the male group(30.4%) and 21 ears of 27 patients in the female group(38.8%).Approximately 12.0% of patients had glaucoma at the same time,however;no significant correlation was found in SNHL prevalence and severity between PXF patient and patients with simultaneous *** was more common in patients with ocular PXF compared to their age-sex matched controls(P <0.05).· CONCLUSION:Most of patients with ocular PXF had SNHL compared to their age-sex matched controls,which could be due to PXF fibrils in the inner *** findings suggest PXF could be a systemic disease.·

关键词： pseudoexfoliation sensory-neural hearing loss glaucoma

Effect of capsular tension ring implantation on predicted refractive error after cataract surgery in patients with pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2020年第4期13卷 587-590页

作者： Mohammad Malekahmadi Sadegh Kazemi Farideh Sharifipour Farshad Ostadian Atefeh Mahdian Rad Mohammad Sadegh Mirdehghan Department of Ophthalmology Infectious Ophthalmologic Research CenterAhvaz Jundishapur University of Medical SciencesAhvaz ***Iran

AIM: To investigate the effect of capsular tension ring(CTR) implantation on predicted refractive error after cataract surgery in patients with pseudoexfoliation(PEX) ***: This double-blind randomized clinical trial was conducted on 60 patients with PEX syndrome referring to Imam Khomeini Hospital affiliated to Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran, for undergoing cataract surgery. The study population was divided into two groups, namely CTR group(n=30) and non-CTR group(control group;n=30). The refractive error and anterior chamber depth(ACD) were measured 1 wk, 1 mo, and 3 mo after phacoemulsification(PE) ***: The results indicated no statistically significant difference between the two groups in terms of predicted refractive error(obtained by subtracting preoperative predicted refractive error from actual postoperative refractive error) 1 wk(P=0.47), 1 mo(P=0.30), and 3 mo(P=0.06) after the PE surgery. Regarding the CTR group, the changes of ACD was statistically significant 1 and 3 mo after the PE surgery, compared to those obtained 1 wk post-surgery(P=0.005).CONCLUSION: The CTR implantation in PEX cataractous patients without zonulysis has no statistically significant effect on the predicted refraction and ACD changes after PE. The predicted refraction error has a hyperopic shift in both groups. The results reveal the unnecessary of calculating modified IOL in CTR implantation.

关键词： pseudoexfoliation syndrome capsular tension ring refraction error anterior chamber

Safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 723-727页

作者： Tevfik Ogurel Reyhan Ogurel Zafer Onaran Kemal Ornek Department of Ophthalmology Kirikkale University Schoolof Medicine Kirikkale University Campus Ankara 71100Yahsihan Turkey

AIM：To evaluate the safety of hydroimplantation in cataract surgery in patients with pseudoexfoliation ***：This prospective randomized study comprised 100 eyes of 100 consecutive patients who underwent cataract surgery and implantation of foldable intraocular lens（IOL）. Each eye was assigned to group 1 or group 2. Hydroimplantation without using viscoelastic agent as group 1（n=50）, and hydroxypropylmethylcellulose（Eyevisc, Biotech, India） was used in group 2（n=50）. RESULTS：There were no statistically significant differences in central corneal thickness（CCT） and corneal endothelial cell count（ECC） between both groups at each visit and percentage change in CCT and ECC（P〉0.05）. The mean intraocular pressure（IOP） at postoperative 5h increased statistically significantly in group 2（P〈0.001）. There was no statistically significant difference in IOP between two groups, before and after surgery excluding the 24 h postoperative IOP, but patients in group 2 had higher IOP than that in the group 1 at 24 h after surgery（P=0.035）. No case in either group experienced posterior capsular rupture, or zonular dialysis. Fixation of the globe during IOL implantation was better in group 1 than that in group ***：Hydroimplantation has advantages in terms of IOP changes and duration of the surgery and seems to be safe in patients with pseudoexfoliation syndrome.

关键词： hydroimplantation pseudoexfoliation phacoemulsification

pseudoexfoliation syndrome and cardiovascular diseases

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World Journal of Cardiology 2014年第8期6卷 847-854页

作者： Georgios K Andrikopoulos Dimitrios K Alexopoulos Sotirios P Gartaganis Department of Ophthalmology University of Patras Medical School26504 PatrasGreece Department of Internal Medicine Division of CardiologyUniversity of Patras Medical School26504 PatrasGreece

pseudoexfoliation(PEX) syndrome is a well-recognized late-onset disease caused by a generalized fibrillopathy. It is linked to a broad spectrum of ocular complications including glaucoma and perioperative problems during cataract surgery. Apart from the long-known intraocular manifestations, PEX deposits have been found in a variety of extraocular locations and they appear to represent a systemic process associated with increased cardiovascular and cerebrovascular morbidity. However, as published results are inconsistent, the clinical significance of the extraocular PEX deposits remains controversial. Identification of PEX deposits in the heart and the vessel wall, epidemiologic studies, as well as, similarities in pathogenetic mechanisms have led to the hypothesis of a possible relation between fibrillar material and cardiovascular disease. Recent studies suggest that PEX syndrome is frequently linked to impaired heart and blood vessels function. Systemic and ocular blood flow changes, altered parasympathetic vascular control and baroreflex sensitivity, increased vascular resistance and decreased blood flow velocity, arterial endothelial dysfunction, high levels of plasma homocysteine and arterial hypertension have all been demonstrated in PEX subjects. Common features in the pathogenesis of both atherosclerosis and PEX, like oxidative stress and inflammation and a possible higher frequency of abdominal aorta aneurysm in PEX patients, could imply that these grey-white deposits and cardiovascular disorders are related or reflect different manifestations of the same process.

关键词： pseudoexfoliation Cardiovascular disease Cerebrovascular disease Coronary artery disease Homocysteine

Posterior Capsular Rent: Risk Factors, Diagnosis and Management

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Surgical Science 2014年第5期5卷 224-226页

作者： Nimmi Rani Prashant Gupta Aravind Eye Hospital Madurai India Cataract Services at Aravind Eye Hospital Madurai India

In spite of a steady improvement in the safety of cataract surgery since the inception of phacoemulsification, diagnosing and managing posterior capsular rent still remains a challenge. Identification of the pre-existing risk factors is of utmost importance so that precautionary modifications are done in the surgery to prevent this complication. Once it happens, timely realization and appropriate management can have excellent outcomes.

关键词： Posterior Capsular Rent Vitreous Loss Traumatic Cataract Small Pupil pseudoexfoliation Vitrectomy Triamcinolone Acetonide

Series of cataract surgeries with I-ring pupil expansion ring

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World Journal of Ophthalmology 2019年第1期8卷 1-6页

作者： Kenneth Lu Martin Garcia Jack Tian Rustum Karanjia Doheny Eye Institute University of California

BACKGROUND The retrospective review of I-ring pupil expansion ring use is designed to examine the patient characteristics and associated surgical challenges in a clinical *** hypothesis is that I-ring provides a necessary additive tool in dealing with challenging cataract surgeries with small *** To document the safety profile and use of I-ring pupil expansion ring in a clinical *** A retrospective chart review of 12 consecutive cases within the same year(2016)of cataract surgeries employing I-ring pupil expansion ring(Beaver-Visitec,International)by a single surgeon at the same ambulatory surgical center was ***,pre-op,intra-op,and post-op data were *** number of cataract cases performed was also *** 8 of 12 cases were planned I-ring cases.1 case was decided intraoperatively when femtosecond laser caused the pupil to *** other 3 cases were also decided upon intraoperatively when pupil was deemed to be small.7 patients had IFIS from Flomax use.2 patients had pseudoexfoliation syndrome as the cause of small pupil.2 patients had narrow angles with brunescent cataracts.2 patients had pre-op partial zonular dehiscence.1 patient had 360o of posterior synechiae.2 cases had ruptured posterior capsule that required anterior *** complications were attributed to the pupil expansion ring.A total of 296 cataract surgeries were performed that year by the surgeon,making the rate of pupil ring use 4.1%.CONCLUSION Small pupil requiring pupil expansion ring during cataract surgery is often associated with other challenges,such as brunescent cataract,zonular weakness,and posterior synechiae in this series.I-ring helped to reduce at least one challenge in these difficult cases.

关键词： Malyugin ring I-ring Small pupil pseudoexfoliation syndrome Cataract Iris retraction IFIS Zonular dehiscence Challenging cataract surgeries Pupil expansion device