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Evaluation of antioxidant capacity and reproductive toxicity of aqueous extract of Thai Mucuna pruriens seeds

Journal of Integrative Medicine 2020年第3期18卷 265-273页

作者： Sitthichai Iamsaard Supatcharee Arun Jaturon Burawat Supataechasit Yannasithinon Saranya Tongpan Sudtida Bunsueb Natthapol Lapyuneyong Pannawat Choowong-in Nareelak Tangsrisakda Chadaporn Chaimontri Wannisa Sukhorum Department of Anatomy Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Research Institute for Human High Performance and Health Promotion Khon Kaen UniversityKhon Kaen 40002Thailand Faculty of Nursing Ratchathani UniversityUbon Ratchathani 34000Thailand School of Medicine Mae Fah Luang UniversityChiang Rai 57100Thailand

Objective: In traditional medicine, the seeds of Thai Mucuna pruriens(T-MP) are used to treat male dysuria and are believed to enhance fertility. However, information pertaining to the toxicity of T-MP and its interaction with other properties is limited. This study was thus conducted to evaluate the antioxidant capacity and subacute toxicity of T-MP in the reproductive ***: Total phenolic content and antioxidant capacity of T-MP seed extract were determined using total phenolic content, 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power *** and female adult rats were treated orally with T-MP at a dosage of 150 or 300 mg/kg body weight for 14 consecutive days. Sex hormones and functional parameters in the liver and kidney were *** of all tissue was conducted using Masson’s trichrome staining. Sperm parameters, including concentration, morphology, acrosome reaction status and DNA damage, were also *** of tyrosine phosphorylated protein(Tyr Pho), androgen receptor and A-kinase-anchoring protein 4(AKAP4) were investigated using the Western blot ***: T-MP seed extract contained phenolic compounds and exhibited high antioxidant capacity with no toxicity at the tested doses. It did not affect liver or kidney function parameters in the male rats, but increased estradiol, aspartate aminotransferase and alanine aminotransferase levels in the ***, it decreased serum progesterone and alkaline phosphatase levels in female rats. Serum and intratesticular testosterone levels were significantly lower in male rats that received a high dosage of T-MP. Histopathological changes were not observed in any tissue treated with T-MP. T-MP also significantly increased sperm concentration(but did not affect sperm parameters), and enhanced testicular Tyr Pho protein and androgen receptor and expression of AKAP4 in ***: T-MP seed extract exhibited antioxidant capacity and was n

关键词： Mamui Mucuna pruriens Reproductive system Subacute toxicity Rats

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Evaluation of the anti-diabetic properties of Mucuna pruriens seed extract

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Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 632-636页

作者： Stephen O Majekodunmi Ademola A Oyagbemi Solomon Umukoro Oluwatoyin A Odeku Department of Pharmaceutics and Pharmaceutical Technology Faculty of PharmacyUniversity of UyoUyoNigeria Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyUniversity of IbadanIbadanNigeria Department of Veterinary Physiology Biochemistry & PharmacologyUniversity of IbadanNigeria Department of Pharmacology and Therapeutics College of MedicineUniversity of IbadanIbadanNigeria

Objective:To explore the antidiabetic properties of Mucuna pruriens(***).Methods: Diabetes was induced in Wistar rats by single intravenous injection of 120 mg/kg of alloxan monohydrate and different doses of the extract were administered to diabetic *** blood glucose level was determined using a glucometer and results were compared with normal and untreated diabetic *** acute toxicity was also determined in albino ***:Results showed that the administration of 5,10,20,30,40,50,and 100 mg/kg of the crude ethanolic extract of *** seeds to alloxan-induced diabetic rats(plasma glucose > 450 mg/dL) resulted in 18.6%,24.9%,30.8%,41.4%,49.7%,53.1%and 55.4%reduction,respectively in blood glucose level of the diabetic rats after 8h of treatment while the administration of glibenclamide (5 mg/kg/day) resulted in 59.7%*** administration of the extract resulted in a significant dose dependent reduction in the blood glucose level(P<0.001).It also showed that the antidiabetic activity of *** seeds resides in the methanolic and ethanolic fractions of the *** toxicity studies indicated that the extract was relatively safe at low doses,although some adverse reactions were observed at higher doses(8-32 mg/kg body weight),no death was ***,oral administration of *** seed extract also significandy reduced the weight loss associated with ***:The study clearly supports the traditional use of *** for the treatment of diabetes and indicates that the plant could be a good source of potent antidiabetic drug.

关键词： Antidiabetic Mucuna pruriens Hypoglycemic activity Toxicity Diabetes mellitus

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The extract of Mucuna pruriens possesses histamine activity

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 29-31页

作者： Reginald NP Nwankwoala Georgewill OA Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesUniversity of Port Harcourt

Objective:To investigate the activity of the active principle in the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity. Methods:The active principle was extracted with 0.0015 M *** strips of guinea pig ileum were prepared and contractile responses were measured using a *** sets of experiment were conducted:（1）.The contraction of the ileum in presence of different concentrations of histamine,2-methylhistamine and the extract of Mucuna pruriens.（2）.The contractile response of the ileum in presence of different concentrations of the extract and antagonists including diphenhydramine,atropine and ***:（1） The extract of Mucuna pruriens hair, 2- methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED50 = 13.0μg/mL,2-methylhistamine ED50=8.5μg/mL and histamine ED50=10.0μg/ mL).（2） Diphenhydramine,an H,antagonist competitively blocked the contractile response of the Mucuna pruriens extract（3） Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ***:These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.

关键词： Mucuna pruriens Histamine activity Itching Irritation

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Effect of aqueous seed extract of Mucuna pruriens on arsenic-induced testicular toxicity in mice

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Asian pacific Journal of Reproduction 2020年第2期9卷 77-82页

作者： Preethi Concessao Laxminarayana Kurady Bairy Archana Parampalli Raghavendra Department of Physiology Melaka Manipal Medical CollegeManipal Academy of Higher EducationManipalKarnataka576104India Department of Pharmacology RAK College of Medical SciencesRAK Medical and Health Sciences UniversityRas Al KhaimahUnited Arab Emirates

Objective:To investigate the protective effects of Mucuna(M.)pruriens against arsenic-induced testicular impairment in albino ***:Thirty-six male albino mice were divided into six groups,with 6 mice in each *** 1 received drinking water as the normal *** 2 to 6 received sodium arsenite(40 mg/L)in drinking *** 3 received sodium arsenite(40 mg/L)and 300 mg/kg body weight(b.w.)of *** 4 received sodium arsenite(40 mg/L)and 500 mg/kg *** *** 5 received sodium arsenite(40 mg/L)and 1000 mg/kg *** *** 6 received sodium arsenite(40 mg/L)and 2000 mg/kg *** ***.N-acetylcysteine and *** were administered orally once a *** were subjected to the above treatments for 45 *** were sacrificed with overdose of ketamine 24 h following drug *** testis was used for biochemical estimations(lipid peroxidation and glutathione),and the epididymis was used to determine the sperm count and ***:Sodium arsenite significantly decreased(P<0.01)the sperm count and glutathione levels of the *** significantly increased(P<0.01)the abnormal architecture of the spermatozoa and lipid peroxidation *** with *** significantly increased the sperm count and the glutathione levels[500 mg/kg *** 1000 mg/kg b.w.(P<0.01)].A significant decrease in sperm abnormality and lipid peroxidation levels[500 mg/kg *** 1000 mg/kg b.w.(P<0.01)]was also ***:The perturbed sperm parameters and antioxidant levels of the arsenic insulted testis are attenuated by 500 mg/kg *** 1000 mg/kg ***.

关键词： Sodium arsenite Mucuna pruriens Sperm morphology Sperm count Testis

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Synergistic effect of Mucuna pruriens and Withania somnifera in a paraquat induced Parkinsonian mouse model

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Advances in Bioscience and Biotechnology 2013年第11期4卷 1-9页

作者： Jay Prakash Satyndra Kumar Yadav Shikha Chouhan Satya Prakash Surya Pratap Singh 1Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India Biomedical Technology and Cell Therapy Research Laboratory Department of Biomedical Engineering Faculty of Medicine McGill University Montreal Canada Department of Biochemistry Faculty of Science Banaras Hindu University Varanasi India

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the development of rigidity, resting tremors and postural instability. Recently, the focus of PD’s treatment has shifted towards herbal medicines. Mucuna pruriens (Mp) and Withania somnifera (Ws) are traditional herbal medicines known to have neuro-protective effects due to the L-DOPA present in Mp seed powder and withanoloides present in Ws root extract. Here, the synergistic effect of Mp and Ws in Parkinsonian mice induced by chronic exposure to paraquat was evaluated. Co-treatment with Mp and Ws for 9 weeks, significantly decreased the elevated nitrite levels and lipid peroxidation found in Parkinsonian mice. In behavioural tests, Mp and Ws treated mice showed a significant decrease in the time taken to cross a narrow beam, an increase in the time of stay on drum in rotarod test and an improvement in the hanging time. Furthermore, it was found that the use of Mp and Ws considerably improved the tyrosine hydroxylase expression in the substantianigra region of the brain. The results suggest that Mp and Ws may provide a platform for future drug discoveries and novel treatment strategies for PD.

关键词： Withinia somnifera Mucuna pruriens Oxidative Stress Tyrosine Hydroxylase Parkinson’s Disease Substantia nigra Motor Dysfunctions

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ACE-I inhibitory peptide fractions from enzymatic hydrolysates of velvet bean (<i>Mucuna pruriens</i>)

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Agricultural Sciences 2013年第12期4卷 767-773页

作者： Maira Rubi Segura-Campos Carlos Paul Espadas-Alcocer Luis Chel-Guerrero David Betancur-Ancona Facultad de Ingeniería Química Universidad Autónoma de Yucatán Mérida México

The hydrolysis of velvet bean (Mucuna pruriens) protein in the presence of Alcalase?-Flavourzyme? and Pepsin-Pancreatin was investigated. The results showed that Alcalase?-Flavourzyme? (29.08%) sequential system catalyzed the hydrolysis most efficiently that Pepsin-Pancreatin (24.78%). In addition, the higher ACE-I inhibitory activity was achieved with the sequential system Alcalase?-Flavourzyme? (33.13%). Furthermore, the concentration of peptides employing an ultrafiltration (UF) system or their purification by gel filtration chromatography showed that the oligomeric peptides with lower molecular weight registered the highest ACE-I inhibitory activity. It has been demonstrated that Mucuna pruriens protein hydrolysates could serve as a source of peptides with ACE inhibitory activity and this activity can be attributed mainly to the mixture of short peptides in the hydrolysate.

关键词： Velvet Bean Mucuna pruriens ACE-I Inhibition Peptide Fractions Enzymatic Hydrolysis

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Incorporation of Leguminous Cover Crops in Smallholder Cassava-Based Production System in Western Tanzania

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American Journal of Plant Sciences 2017年第13期8卷 3490-3501页

作者： Peter Z. Matata Alexandre M. A. Passos Leah W. Masolwa Alaerto L. Marcolan Rodrigo da S. Ribeiro Tumbi Agricultural Research Institute Tabora Tanzania Embrapa Maize and Sorghum Sete Lagoas Brazil Embrapa Rondonia Porto Velho Brazil Federal University of Rondonia Rolim de Moura Brazil

Small-scale crop production in many parts of Tanzania is constrained by many problems among which soil fertility degradation is a major problem. Over 80% of cassava (Manihot esculenta) production in Tanzania is done by the small-scale farmers who continuously cultivate their fields, but use limited inputs to restore depleted plant nutrients. The objective of this study was to examine the best legume species that could be incorporated in cassava (Manihot esculenta) production systems under farmers’ conditions and result in increase in soil fertility and crop yields. Mucuna pruriens and Canavalia ensiformis were either incorporated with cassava (Manihot esculenta) or planted as sole crop in rotation with cassava. Mucuna pruriens and Canavalia ensiformis were found to produce almost similar amount of biomass. The two legumes, however, produced higher biomass in rotation than intercropping system. The amount of biomass produced by Mucuna pruriens and Canavalia ensiformis in rotation system was 6.28 t·ha-1 and 5.31 t·ha-1, respectively. The Mucuna use represents an input of nitrogen into the soil which simulates a saving cost of 181.42 and 141.96 US$ ha-1. In the first year, cassava root yields were significantly increased (p pruriens (2.41 t·ha-1) and or Canavalia ensiformis (2.25 t·ha-1). Intercropping and rotation of cassava with legumes increase cassava yield and represent a sustainable alternative to reduce the farms’ dependence on external inputs and to enhance inherent soil fertility.

关键词： Mucuna pruriens Canavalia ensiformis Intercropping Rotation Climate Change

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Physicochemical and Functional Characterization of <i>Mucuna pruries</i>Depigmented Starch for Potential Industrial Applications

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International Journal of Organic Chemistry 2015年第1期5卷 1-10页

作者： Maira Rubi Segura-Campos Sonia Marina López-Sánchez Arturo Castellanos-Ruelas David Betancur-Ancona Luis Chel-Guerrero Facultad de Ingeniería Química Universidad Autónoma de Yucatán Mérida México

Starch is a very important biopolymer in the food industry. The velvet bean (M. pruriens) is an excellent potential starch source containing approximately 520 g starch per kg. The objective of this study was to evaluate the physicochemical and functional properties of velvet bean depigmented starch. The starch granules appear oval and spherical shaped. The colour registered L*, a*, b* values of 44.9, 0.324 and 0.341 respectively. The chemical composition registered values of moisture, ash, fat, protein, fibre and NFE of 110.5, 5.8, 5.7, 0.0, 34 and 954.5 g/kg respectively, as well as amylose levels of 215.3 g/kg. Gelatinization onset (To), peak (Tp) and final (Tf) temperatures were of 74.23°C, 80.57°C and 86.39°C. The solubility (3.1% - 16.2%), swelling power (SP) (2.86% - 16.17%) and water absorption capacity (WAC) (2.67 - 15.95 g water/g starch) were directly correlated to temperature (60°C - 90°C). The enthalpy values (4.10 - 13.47 j/g) were directly correlated to the time (1 - 21 days). The retrogradation increased as time increased. The viscosity of M. pruriens depigmented starch decreased slightly during the heating stages and then increased during cooling and the refrigeration and freezing stability registered syneresis ranges from 17.65 to 23.18 mL/50mL and from 16.4 to 22.6 mL/50mL respectively, indicating that the depigmented starch was unstable in heating-cooling processes.

关键词： Depigmented Starch Functional Properties Mucuna pruriens Physicochemical Properties

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