检索结果-南通市图书馆

protein quality control in Plant Organelles:Current Progress and Future Perspectives

Molecular Plant 2021年第1期14卷 95-114页

作者： Jing-Liang Sun Jin-Yu Li Mei-Jing Wang Ze-Ting Song Jian-Xiang Liu State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310027China

The endoplasmic reticulum,chloroplasts,and mitochondria are major plant organelles for protein synthesis,photosynthesis,metabolism,and energy *** homeostasis in these organelles,maintained by a balance between protein synthesis and degradation,is essential for cell functions during plant growth,development,and stress ***-encoded chloroplast-and mitochondrion-targeted proteins and ER-resident proteins are imported from the cytosol and undergo modification and maturation within their respective *** folding is an error-prone process that is influenced by both developmental signals and environmental cues;a number of mechanisms have evolved to ensure efficient import and proper folding and maturation of proteins in plant *** or damaged proteins with nonnative conformations are subject to degradation via complementary or competing pathways:intraorganelle proteases,the organelle-associated ubiquitin-proteasome system,and the selective autophagy of partial or entire *** proteins in nonnative conformations accumulate,the organellespecific unfolded protein response operates to restore protein homeostasis by reducing protein folding demand,increasing protein folding capacity,and enhancing components involved in proteasome-associated protein degradation and *** review summarizes recent progress on the understanding of protein quality control in the ER,chloroplasts,and mitochondria in plants,with a focus on common mechanisms shared by these organelles during protein homeostasis.

关键词： autophagy chloroplast-associated protein degradation ER-associated protein degradation mitochondria-associated protein degradation protein quality control unfolded protein response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

protein quality control of cell stemness

引用

Cell Regeneration 2020年第1期9卷 259-269页

作者： Pengze Yan Jie Ren Weiqi Zhang Jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China China National Center for Bioinformation Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Brain Disorders Advanced Innovation Center for Human Brain ProtectionNational Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China.

protein quality control(PQC)systems play essential roles in the recognition,refolding and clearance of aberrant proteins,thus ensuring cellular protein homeostasis,or ***,continued proliferation and differentiation of stem cells require a high rate of translation;therefore,accurate PQC systems are essential to maintain stem cell *** evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem *** review focuses on current knowledge regarding the components of the proteostasis network in stem cells,and the importance of proteostasis in maintaining stem cell identity and regenerative functions.A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases.

关键词： protein quality control Stem cells Stemness Chaperones Unfolded protein response Ubiquitinproteasome system Autophagy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Sight into DegP’s Role in protein quality control

New Sight into DegP’s Role in Protein Quality Control

引用

第八届全国化学生物学学术会议

作者： Zhi-Xin Lyu Xin-Sheng Zhao Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineeringand Biodynamic Optical Imaging Center（BIOPIC）Peking University

＜正＞The heat-shock protein DegP is essential for the survival of Escherichia coli cells at elevated *** binding transforms hexameric DegP into large, catalytically active ***,whether DegP performs chaperone activity... 详细信息

关键词： Protease Chaperone protein quality control Single molecule FRET

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

The Discovery of DesCEND: An end-directed protein elimination mechanism functions in protein quality control

The Discovery of DesCEND: An end-directed protein eliminatio...

引用

中国生物化学与分子生物学会第十二届全国会员代表大会暨2...

作者： Hsiu-Chuan Lin Hsueh-Chi S.Yen Institute of Molecular Biology Academia Sinica Genome and Systems Biology Degree Program National Taiwan University and Academia Sinica

The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant *** miscellaneous defective proteins are specifically eliminated and which molecular characteristics direct them for removal are fundamental *** reveal a mechanism,DesCEND(Destruction via C-ENd Degrons),by which CRL2 ubiquitin ligase uses interchangeable substrate receptors to recognize the unusual C-termini of abnormal proteins,i.e.C-degrons.C-degrons are mostly less than ten residues in length and comprise a few indispensable residues along with some rather degenerate *** C-terminal end-position is essential for C-degron function,and ectopic placement of C-end degrons is sufficient to direct otherwise stable proteins for *** selenoproteins generated by translation errors and the USP1 N-terminal fragment from post-translational cleavage are eliminated by *** C-degron in DesCEND echoes the N-degron in the N-end rule pathway,highlighting the dominance of protein "ends" as indicators of protein quality/integrity.

关键词： protein quality control CRL2 ubiquitin ligase DesCEND C-end degrons C-end rule

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Regulation of immune-related diseases by multiple factors: a meeting report of 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology

引用

Acta Pharmaceutica Sinica B 2017年第4期7卷 532-540页

作者： Bing Cui Xuetao Cao Weiping Zou Yonghong Wan Ning Wang Yaohe Wang Pingping Li Fang Hua Yuying Liu Xiaowei Zhang Ke Li Xiaoxi Lv Bo Huang Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical College National Key Laboratory of Medical Molecular Biology Department of ImmunologyInstitute of Basic Medical SciencesPeking Union Medical CollegeChinese Academy of Medical Sciences Department of Surgery University of Michigan School of Medicine The University of Michigan Comprehensive Cancer Center University of Michigan Graduate Programs in Immunology and Tumor Biology University of Michigan Department of Pathology and Molecular Medicine Mc Master Immunology Research CentreMc Master University Department of Mechanical Science and Engineering University of Illinois at Urbana-Champaign Laboratory for Cellular Biomechanics and Regenerative Medicine Department of Biomedical EngineeringSchool of Life Science and TechnologyHuazhong University of Science and Technology Center for Molecular Oncology Barts Cancer InstituteQueen Mary University of London School of Basic Medical Sciences Academy of Medical SciencesZhengzhou University Sino-British Research Centre for Molecular Oncology National Center for International Research in Cell and Gene TherapyZhengzhou University Diabetes Research Center of Chinese Academy of Medical Sciences Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Clinical Immunology Center Chinese Academy of Medical Sciences Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&Technology

Immune cells play key roles in cancer and chronic inflammatory disease. A better understanding of the mechanisms and risks will help develop novel target therapies. At the 2017 International Workshop of the Chinese Academy of Medical Sciences Initiative for Innovative Medicine on Tumor Immunology held in Beijing, China, on May 12, 2017, a number of speakers reported new findings and ongoing studies on immune-related diseases such as cancer, fibrotic disease, diabetes, and others. A considerably insightful overview was provided on cancer immunity, tumor microenvironments,and new immunotherapy for cancer. In addition, chronic inflammatory diseases were discussed. These findings may offer new insights into targeted immunotherapy.

关键词： Tumor Immunology Chromatin Exosomes Microparticles Vaccines Oxidative stress Dormancy protein quality control Inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Salicylic Acid Signaling controls the Maturation and Localization of the Arabidopsis Defense protein ACCELERATED CELL DEATH6

引用

Molecular Plant 2014年第8期7卷 1365-1383页

作者： Zhongqin Zhang Jay Shrestha Chika Tateda Jean T. Greenberg Department of Molecular Genetics and Cell Biology University of Chicago 929 East 57 Street GCIS W524 Chicago IL 60637 USA

ACCELERATED CELL DEATH6 （ACD6） is a multipass membrane protein with an ankyrin domain that acts in a positive feedback loop with the defense signal salicylic acid （SA）. This study implemented biochemical approaches to infer changes in ACD6 complexes and localization. In addition to forming endoplasmic reticulum （ER）- and plasma membrane （PM）-Iocalized complexes, ACD6 forms soluble complexes, where it is bound to cytosolic HSP70, ubiquitinated, and degraded via the proteasome. Thus, ACD6 constitutively undergoes ER-associated degradation. During SA signaling, the soluble ACD6 pool decreases, whereas the PM pool increases. Similarly, ACD6-1, an activated version of ACD6 that induces SA, is present at low levels in the soluble fraction and high levels in the PM. However, ACD6 variants with amino acid substitutions in the ankyrin domain form aberrant, inactive complexes, are induced by a SA agonist, but show no PM localization. SA signaling also increases the PM pools of FLAGELLIN SENSING2 （FLS2） and BRI1-ASSOClATED RECEPTOR KINASE 1 （BAK1）. FLS2 forms complexes ACD6; both FLS2 and BAK1 require ACD6 for maximal accumulation at the PM in response to SA signaling. A plausible scenario is that SA increases the efficiency of productive folding and/or complex formation in the ER, such that ACD6, together with FLS2 and BAK1, reaches the cell surface to more effectively promote immune responses.

关键词： ACD6 protein trafficking protein quality control salicylic acid.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer

引用

Acta Pharmaceutica Sinica B 2019年第2期9卷 443-454页

作者： Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Department of Biochemistry Institute of Integrative Biology University of Liverpool Division of Molecular Biology and Biochemistry School of Biological Sciences University of Missouri-Kansas City School of Biological Sciences Nanyang Technological University Lee Kong Chian School of Medicine Nanyang Technological University Institute of Molecular and Cell Biology KK Women's and Children Hospital Biochemistry Department School of Biomedical Sciences University of Otago Centre for Biomedical Research (CBMR) University of Algarve Campus de Gambelas Department of Biomedical Sciences and Medicine University of Algarve Algarve Biomedical Center (ABC) University of Algarve Campus de Gambelas Department of Infection Immunity and Cardiovascular Disease University of Sheffield Paul O'Gorman Leukaemia Research Centre Institute of Cancer Sciences University of Glasgow Division of Carcinogenesis The Cancer Institute Japanese Foundation for Cancer Research Department of Pathology and Laboratory Medicine Abramson Family Cancer Research Institute Perelman School of Medicine at the University of Pennsylvania Centre de Recherche en Transplantation et Immunologie (ou CRTI) Inserm Université de Nantes Nantes France Institut de Transplantation Urologie Néphrologie (ou ITUN) CIC bioGUNE CIBERONC Ikerbasque Basque Foundation for Science Biochemistry and Molecular Biology Department University of the Basque Country (UPV/EHU) Institute for Diabetes and Cancer IDC Helmholtz Center Munich Joint Heidelberg-IDC Translational Diabetes Program University Hospital Heidelberg Molecular Metabolic control Medical Faculty Technical University Munich German Center for Diabetes Research (DZD) Division of Cardiology Department of Medicine Columbia University Irving Medical Center School of Sport and Health Sciences Cardiff Metropolitan Universit

The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases.

关键词： Tribbles Immunology Metabolism Cell biology Kinase inhibitor Tumorigenesis Metastasis TRIB1 TRIB2 TRIB3 Pseudokinase Inflammation Atomic structure protein quality control Ubiqutin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The quality control mechanism for the transloction of the outer membrane proteins in the periplasm of Gram-negative bacteria

The quality control mechanism for the transloction of the ou...

引用

第一届全国生物物理化学会议暨生物物理化学发展战略研讨会

作者： Si Wu~1,Xi Ge~2,Zeyong Zhi~1,and Zengyi Chang~2,Xin Sheng Zhao~(1,*) 1 Beijing National Laboratory for Molecular Sciences,State Key Laboratory for Structural Chemistry of Unstable and Stable Species,and Department of Chemical Biology,College of Chemistry and Molecular Engineering,Peking University,Beijing,100871,China 2 The Center for protein Science,The National Laboratory of protein Engineering and Plant Genetic Engineering,and College of Life Science,Peking University,Beijing,100871,China

＜正＞The outer membrane proteins（OMPs） of the Gram negative bacteria have to be translocated through the cytoplasm,the inner membrane,and the periplasmic space before reaching their final *** highly fluctuating nature of the periplasmic space,due to the high permeability of the outer membrane,engenders such translocation process inevitably challenging and would have to rely on an efficient quality control

关键词： outer membrane protein DegP single molecule fluorescence protein quality control

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Single Molecule Study Reveals the Functions of DegP

Single Molecule Study Reveals the Functions of DegP

引用

第八届全国化学生物学学术会议

作者： Xin Sheng Zhao Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable SpeciesDepartment of Chemical BiologyCollege of Chemistry and Molecular Engineeringand Biodynamic Optical Imaging Center（BIOPIC）Peking University

＜正＞DegP belongs to the HtrA *** a heat-shock-like protein,DegP is said to have protease/chaperone dual function and is essential for the survival of Escherichia coli at elevated ***,whether DegP truly performs chaperone activity has long been under ***,the quality control mechanism of DegP on biogenesis of outer membrane proteins（OMPs） is poorly *** single molecule detection study has provided evidence that besides protease activity DegP

关键词： Protease Chaperone protein quality control Single molecule FRET

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Using the iPlant cyberinfrastructure to explore the connection between heterosis and cellular aging

Using the iPlant cyberinfrastructure to explore the connecti...

引用

第十四届全国植物基因组学大会

作者： Stephen A.Goff iPlant Collaborative BIO5 InstituteUniversity of Arizona

Gene expression profiling and biochemical analysis suggests that hybrids have more efficient protein quality control mechanisms than their inbred parental *** on the molecular mechanisms of aging suggest that inbreedi... 详细信息

关键词： iPlant cyberinfrastructure heterosis protein quality control protein folding protein stability protein turnover molecular aging

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：