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Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of Proinflammatory Macrophages via Notch Signaling Pathway

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Current Medical Science 2019年第4期39卷 526-533页

作者： Jian-sha LI Lu-yao FAN Meng-dan YUAN Ming-you XING Institute of Pathology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Pathology School of Basic Medical ScienceTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Infectious Diseases Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Activation of macrophages is a key event for the pathogenesis of various inflammatory *** signaling pathway recently has been found to be a critical pathway in the activation of proinflammatory *** (Sal),one of main bioactive components in Rhodiola crenulata (*** Thoms) ***,reportedly possesses anti-inflammatory activity and ameliorates inflammation in alcohol-induced hepatic ***,whether Sal regulates the activation of proinflammatory macrophages through Notch signaling pathway remains *** present study investigated the effects of Sal on macrophage activation and its possible mechanisms by using both alcohol and lipopolysaccharide (LPS) to mimic the microenvironment of alcoholic *** of THP-1-derived macrophages exhibited that Sal could significantly decrease the expression of tumor necrosis factor-α(TNF-α),interleukinbeta (IL-1β)and IL-6 in the macrophages at both mRNA and protein ***,Sal significantly suppressed NF-kB activation via Notch-Hes signaling pathway in a dose-dependent ***,in the microenvironment of alcoholic liver,the expression of Notch-dependent pyruvate dehydrogenase phosphatase 1 (PDP1) was elevated,and that of Ml gene expression [inducible NO synthase (NOS2)] was *** changes could all be effectively ameliorated by *** aforementioned findings demonstrated that Sal could inhibit LPS-ethanol-induced activation of proinflammatory macrophages via Notch signaling pathway.

关键词： THP-1 macrophages Salidroside Notch tumor necrosis factor-α monocyte chemoattractant protei-1

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