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Roles of nitric oxide in protective effect of berberine in ethanol-induced gastric ulcer mice

Acta Pharmacologica Sinica 2005年第11期26卷 1334-1338页

作者： Long-tui PAN~(2,3), Qiang TANG~2, Qin FU~2, Ben-rong HU~2, Ji-zhou XIANG~(2,4), Jia-qing QIAN~2 ~2 Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China ~3 Department of Pharmacology, Yunyang Medical College, Shiyan 442000, China Department of Pharmacology Tongji Medical College of Huazhong University of Science and Technology Wuhan China Department of Pharmacology Yunyang Medical College Shiyan China

Aim: To investigate the protective effects of berberine on ethanol-induced gastric ulcer in mice. Methods: Gastric ulcers were induced by oral ingestion of ethanol. Nitric oxide (NO) content was measured, and mRNA expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS) were analyzed by reverse transcription-polymerase chain reaction (RT-PCR). Results: The ulcer index (UI) at 1 h, 2 h, 3 h and 6 h after oral administration of ethanol was 23.8■1.4,23.3■2.2,22.3■1.2 and 20.8■1.1, respectively. The UI in the berberine-treated groups (5 mg/kg and 50 mg/kg) was less than the control group. The content of NO in the control group was 73.3+7.3 μL/L, 94.0■9.2 μL/L, 109.6■ 6.4 μL/L and 138.2■10.2 μU/L in gastric juice and 5.8■1.1 μmol/g protein, 8.3■ 1.1 μmol/g protein, 9.8■ 1.1 μmol/g protein and 11.9■ 1.2 μmol/g protein in gastric tissue at 1 h, 2 h, 3 h and 6 h, respectively, after the oral administration of ethanol. The content of NO in the berberine-treated groups (5 mg/kg and 50 mg/kg) was higher than the control group at 1 h after the oral administration of ethanol (Pethanol. However, the expression of eNOS could be enhanced and iNOS expression could be inhibited by berberine (Pethanol. This effect may be related to the increased expression of eNOS mRNA and inhibited expression of iNOS mRNA.

关键词： berberine nitric oxide protective agents ethanol-induced disorders stomach ulcer

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