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Multi-omics analysis to identify CBR3-AS1-hsa-miR-145-5p-MAP3K5 pathway as a ferroptosis-related ceRNA network in benign prostatic hyperplasia

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Genes & Diseases 2024年第5期11卷 105-108页

作者： Liang Zhou Youyou Li Jiaren Li Hanyu Yao Jin Huang Cheng Li Long Wang Department of Urology The Third Xiangya Hospital of Central South UniversityChangshaHunan 410013China

In aging males,benign prostatic hyperplasia(BPH)is a chronic pathological process that primarily causes lower urinary tract *** to histopathology,BPH is caused by an imbalance between cell death and proliferation.1 However,the exact pathophysiology remains *** is a newly discovered form of programmed cell *** cell morphology is characterized primarily by the reduction or disappearance of mitochondrial cristae and mitochondrial shrinkage.2,3 Competing endogenous RNAs(ceRNAs)are important regulators of many biological processes and have been involved in various diseases.

关键词： prostatic endogenous BPH

Does prostate-specific antigen (PSA)mass or free PSA mass improve the accuracy of predicting total prostate volume in relation to obesity in men with biopsy-proven benign prostatic hyperplasia?

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Asian Journal of Andrology 2019年第1期21卷 86-91页

作者： Jin-Woo Jung young Dong Yu Young Ju Lee Jung Jun Kim Hak Min Lee Jong Jin Oh Sangchul Lee Sang Wook Lee Sang Eun Lee Seong Jin Jeong Department of Urology Catholic Kwandong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea

We evaluated whether the prostate-specific antigen (PSA)mass or free PSA (fPSA)mass (i.e.,absolute amount of total circulating PSA or fPSA protein,respectively),versus serum PSA or fPSA concentration,improves the accuracy of predicting the total prostate volume (TPV)in relation to *** men whose multicore (≥12)transrectal prostate biopsy was negative,586 who had a PSA of <10 ng ml^-1 and underwent the fPSA test prior to biopsy were *** PSA mass or fPSA mass (pg)was calculated by multiplying the serum level by plasma *** each TPV cut-off point (30 ml,40 ml,and 50 ml),the areas under the receiver operating characteristics curve (AUCs)of each variable were compared in obesity-based *** of fPSA and fPSA mass for predicting TPV were significantly larger than those for PSA and PSA mass by 8.7%-12.1%at all cut-off points. Subgroup analyses based on obesity showed that,although PSA mass and fPSA mass enhanced accuracy by 4%(P =0.031)and 1.8%(P =0.003),respectively,for determining TPVs of ≥30 ml and ≥50 ml in obese and overweight men,they did not improve the accuracy in most other combinations of the degrees of obesity with TPV cut-off ***,compared with serum PSA or fPSA,the absolute amount of PSA or fPSA protein mass improved the accuracy of predicting TPV in obese men very minimally and only for certain TPV cut-off ***,these indicators may not provide clinically meaningful improvement in predicting TPV in obese men.

关键词： benign prostatic hyperplasia obesity prostate volume prostate-specific antigen mass

prostatic small cell carcinoma with resultant tumor thrombus to the right iliac vein

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Asian Journal of Urology 2024年第4期11卷 666-668页

作者： Chris Perez Mark E.Quiring Lendon Hall Katelyn Klimowich Young Son Thomas Mueller Gordon Brown Douglas Berkman Touro University California College of Osteopathic MedicineVallejoCAUSA University of North Texas Health Science Center Texas College of Osteopathic MedicineFort WorthTXUSA Jefferson Health New Jersey Department of UrologyStratfordNJUSA

Dear Editor,prostatic small cell carcinoma(SCC)is a rare,deadly tumor with an overall median survival of fewer than 12 months[[1],[2],[3],[4],[5]].Here we describe a unique case of a patient with prostatic SCC who dev... 详细信息

关键词： thrombus iliac prostatic

A case of obstructive azoospermia secondary to genitourinary tract infection caused by a prostatic utricle cyst

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Asian Journal of Andrology 2022年第5期24卷 558-559页

作者： Tomoki Saito Mitsuru Komeya Kimitsugu Usui Shinnosuke Kuroda Teppei Takeshima Kunitomo Takashima Mario Ikeda Yoshihito Kondo Yasushi Yumura Department of Urology Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohama CityKanagawa 232-0024Japan Department of Urology Yokohama City University Graduate School of Medicine3-9 FukuuraKanazawa-kuYokohama CityKanagawa 236-0004Japan Ebina Ladies Clinic 3-3-1 ChuoEbina CityKanagawa 243-0432Japan

Dear Editor,Obstructive azoospermia(OA)is defined as the absence of spermatozoa in the sediment of a centrifuged sample of ejaculate and is usually caused by an obstruction anywhere along the posttesticular *** is diagnosed in 20%–40%of men with *** OA may be acquired congenitally,such as in Young’s syndrome that presents with bilateral vas deferens abnormalities,it commonly develops as a sequela of prostatic and ejaculatory duct cysts,childhood inguinal hernias,epididymitis,and vasectomy.

关键词： prostatic azoospermia urinary

Testosterone therapy: a friend or a foe for the aging men with benign prostatic hyperplasia?

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Asian Journal of Andrology 2020年第3期22卷 233-235页

作者： Giulia Rastrelli Linda Vignozzi Mario Maggi Sexual Medicine and Andrology Unit Department of Experimental and Clinical Biomedical SciencesUniversity of FlorenceViale PieracciniFlorence 61-50139Italy LN.B.B. Biostructures and Biosystems National InstituteViale delle Medaglie d'Oro305Rome 1-00136Italy Endocrinology Unit Department of Experimental Clinical and Biomedical Sciences"Mario Serio"University of FlorenceViale PieracciniFlorence 61-50139Italy.

One of the major concerns for the prescription of medications containing testosterone(T)in the aging men with T deficiency(TD)is prostate disorders(such as benign prostatic hyperplasia,BPH)and their related symptoms(lower urinary tract symptoms,LUTS).This is because prostate is an androgen-responsive gland;however,the androgen dependence of prostate growth,well demonstrated in earlier phases of life,has no clear evidence in late adulthood and *** fact,after the age of 40 years,BPH becomes increasingly more *** the other hand,in men older than 40 year,a progressive decline in T is *** epidemiological data are a starting point for questioning a putative detrimental role of T on the prostate health in the ageing man.

关键词： prostatic BPH prescription

Transurethral vesiculoscope-assisted laser incision of the prostatic utricle to treat partial ejaculatory duct obstruction

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Asian Journal of Andrology 2021年第1期23卷 120-121页

作者： Ke-Nan Wang Wen-Long Xie Lei Zheng Tao Jiang Department of Andrology First Affiliated Hospital of Dalian Medical UniversityDalian 116011China Department of Ultrasound First Affiliated Hospital of Dalian Medical UniversityDalian 116011China

Dear Editor,The patient was a 29-year-old male seeking medical treatment for a 2-year history of prim ary infertility,and no reproductive abnormalities were observed in his 29-year-old *** study protocol was approved by the Ethics C om m ittee of the First Affiliated Hospital of Dalian Medical University(Dalian,China),and the inform ed consent was provided by the patient for the publication of his clinical data.

关键词： prostatic obstruction clinical

Curative Effect of Electro-acupuncture and Tuina on prostatic Hypertrophy

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Journal of Acupuncture and Tuina Science 2003年第3期1卷 27-30页

作者： LIU Gui-zhen HUANG Yong WANG Ai-min SHE Zhi-qing YAO Ren-min SHEN wei-na Central Hospital of Putuo District Shanghai 200062 China Central Hospital of Putuo District Shanghai 200062 China Central Hospital of Putuo District Shanghai 200062 China Central Hospital of Putuo District Shanghai 200062 China Hong Kong University china

Objective To observe the curative effect of electro-acupuncture plus Tuina on prostatic *** Fifty-six cases of prostatic hypertrophy were treated according to the principle of taking the kidney as the main aspect. Points Guanyuan (CV 4), Qugu ( CV2), Shenshu(BL 23), Ciliao(BL32) and Sanyinjiao( SP6) were selected and electro-acupuncture were used together with Tuina. Those who took the tablet Finasteride orally were treated as the control group. Result The total effective rate was 94.6% in treating group, while that was 86.7% in the control group, P＞0.05. Conclusion It is suggested that electro-acupuncture plus Tuina has a certain effect on prostatic hypertrophy. Compared with western medicine, it is lower in price and has no side effect.

关键词： Electroacupuncture Massage Tuina prostatic Hypertrophy

prostatic Small Cell Carcinoma: Diagnosis and Management

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Journal of Cancer Therapy 2013年第3期4卷 804-810页

作者： Parminder Singh Amit. M. Algotar Erika R. Bracamonte The University of Arizona Cancer Center Tucson USA

prostatic small cell carcinoma (PSCC) is a distinct clinical phenotype of prostate cancer. Although rare, this phenotype is highly aggressive with very high mortality. Due to this, it is imperative for clinicians to be aware of it, diagnose it early and treat it appropriately. In this article we discuss the current literature, outline a plan for its diagnosis and management, and highlight latest research on this topic.

关键词： prostatic Small Cell Carcinoma Prostate Cancer Neuroendocrine Tumor

Commentary on "Integrative multiplatform molecular profiling of benign prostatic hyperplasia identifies distinct subtypes"

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Chinese Medical Journal 2023年第5期136卷 539-540页

作者： Zhemin Lin Yinong Niu Department of Urology Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China

Benign prostatic hyperplasia(BPH)occurs commonly in older males,with its prevalence increasing linearly with age,reaching approximately 50%and 80%in males aged 60 and 90 years,respectively.[1]Histologically,BPH is characterized by smooth muscle and epithelial cell proliferation within the prostatic transitional *** anatomical compression of the urethra causes increased bladder outlet resistance and detrusor muscle irritability,usually resulting in lower urinary tract symptoms(LUTS),which can be bothersome and make patients seek medical care.

关键词： prostatic bladder BPH