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prostate cancer screening:Continued controversies and novel biomarker advancements

当代泌尿学（英文） 2022年第4期16卷 197-206页

作者： Atiyah Tidd-Johnson Sneha Annie Sebastian Edzel Lorraine Co Munaza Afaq Hansini Kochhar Mona Sheikh Arpit Mago Sujan Poudel John A.Fernandez Ivan D.Rodriguez Sanjay Razdan Division of Research & Academic Affairs Larkin Community HospitalSouth MiamiFLUSA Department of Medicine American University of Antigua College of MedicineCoolidgeAntigua Division of Research & Academic Affairs Larkin Community HospitalSouth MiamiFLUSA Division of Research & Academic Affairs Larkin Community HospitalSouth MiamiFLUSA Department of Internal Medicine Larkin Community HospitalSouth MiamiFLUSA Division of Research & Academic Affairs Larkin Community HospitalSouth MiamiFLUSA Department of Family Medicine Larkin Community HospitalSouth MiamiFLUSA Division of Research & Academic Affairs Larkin Community HospitalSouth MiamiFLUSA Department of Urology Larkin Palm Springs HospitalSouth MiamiFLUSA Department of Urology Larkin Community HospitalSouth MiamiFLUSA

prostate cancer(PCa)screening remains one of the most controversial topics in clinical and public *** being the second most common cancer in men worldwide,recommendations for screening using prostate-specific antigen(PSA)are *** de-tection and the resulting postscreening treatment lead to overdiagnosis and overtreatment of otherwise indolent *** addition,sev-eral unwanted harms are associated with PCa screening *** literature review focuses on the limitations of PSA-specific PCa screening,reasons behind the screening controversy,and the novel biomarkers and advanced innovative methodologies that improve the limitations of traditional screening using *** the verdict of whether or not to screen not yet unanimous,we hope to aid in res-olution of the long-standing debate.

关键词： Biopsy Multiparametric magnetic resonance imaging Liquid biopsy Novel biomarkers prostate cancer prostate cancer screening prostate-specific antigen Tumor markers

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prostate-specific antigen （PSA） velocity： a test of controversial benefit in the era of increased prostate cancer screening

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Asian Journal of Andrology 2011年第4期13卷 614-615页

作者： Michael S Borofsky Danil V Makarov Department of Urology New York University School of Medicine New York NY 10016 USA Department of Urology and The Section on Value and Comparative Effectiveness New York University School of Medicine New York NY 10016 USA

Determining the need for prostate biopsy remains one of the most controversial questions in urology. Over the past 10 years, practice guidelines have changed dramatically, especially among asymptomatic men with low pr... 详细信息

关键词： prostate-specific antigen controversial benefit prostate cancer screening

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总体和自由型前列腺特异抗原指数在日本人群前列腺癌筛选中的价值和局限性(英文)

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Asian Journal of Andrology 2006年第4期8卷 429-434,514-515页

作者： Noboru Hara YasuoKitamura ToshihiroSaito ShuichiKomatsubara Department of Urology Niigata Cancer Center HospitalNiigata 951-8133Japan Division of UrologyDepartment of Regenerative and Transplant MedicineGraduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan Department of Urology Niigata Cancer Center HospitalNiigata 951-8133Japan

Aim:To assess the efficacy and limitation of free/total prostate-specific antigen ratio(f/tPSA)at a single institution in Japan,focusing on the avoidance of pointless prostate ***:In total,631 men between 44 and 93 years old(mean 69.8 years)with elevated PSA underwent power-Doppler ultrasoundgraphy-guided transrectal 10-core prostate biopsies at Niigata cancer Center Hospital,and their histological features were investigated with total PSA (tPSA)and f/***:PCa was detected in 126 of 134 patients(94.3%)with tPSA of 26 ng/mL or *** detection rate was 59.4% for tPSA of 21-25 ng/mL,followed by 39.2% for 16-20 ng/mL,30.0% for 11-15 ng/mL, 20.0% for 4.1-10 ng/mL and 7.6% for≤4.0 ng/mL,f/tPSA of the PCa group was significantly lower than that of non-malignamt disorders in any tPSA ranges(mean 0.122 vs.0.160,Pscreening for Asian men having so-called grey-zone tPSA.(Asian J Androl 2006 Jul;8:429-434)

关键词： prostate cancer screening free/total prostate-specific antigen ratio multi-site biopsy single-institutional trial

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