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effects of prostaglandin e combined with continuous renal replacement therapy on septic acute kidney injury

World Journal of Clinical Cases 2020年第13期8卷 2738-2748页

作者： Li Lei Ming-Jun Wang Sheng Zhang Da-Jun Hu Department of Nephrology the Second People's Hospital of Three Gorges University(Yichang Second People's Hospital)Yichang 443000Hubei ProvinceChina Institute of Nephrology of Integrated Chinese and Western Medicine of Three Gorges University Yichang 443000Hubei ProvinceChina

BACKGROUND The effects of prostaglandin e(PGe)combined with continuous renal replacement therapy(CRRT)on renal function and inflammatory responses in patients with septic acute kidney injury(SAKI)remain *** To investigate the effects of PGe combined with CRRT on urinary augmenter of liver regeneration(ALR),urinary Na+/H+exchanger 3(NHe3),and serum inflammatory cytokines in patients with *** The clinical data of 114 patients with SAKI admitted to Yichang Second People's Hospital from May 2017 to January 2019 were ***-three cases treated by CRRT alone were included in a control group,while the other 61 cases treated with PGe combined with CRRT were included in an experimental *** urinary ALR,urinary NHe3,serum inflammatory cytokines,renal function indices,and immune function indices were *** in disease recovery and the incidence of adverse reactions were *** 28-d survival curve was *** Before treatment,urinary ALR,urinary NHe3,blood urea nitrogen(BUN),serum creatinine(SCr),CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio in the control and experimental groups were approximately the *** treatment,urinary ALR and NHe3 decreased,while BUN,SCr,CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio increased in all *** ALR,urinary NHe3,BUN,and SCr in the experimental group were significantly lower than those in the control group,while CD3+T lymphocytes,CD4+T lymphocytes,and CD4+/CD8+T lymphocyte ratio were significantly higher than those in the control group(Per treatment,the levels of tumor necrosis factor-α,interleukin-18,and high sensitivity C-reactive protein in the experimental group were significantly lower than those in the control group(Pe time for urine volume recovery and intensive care unit treatment in the experimental group was significantly shorter than that in the control group(Pere was no statistical

关键词： prostaglandin e Continuous renal replacement therapy Septic acute kidney injury Augmenter of liver regeneration Na+/H+exchanger 3 Serum inflammatory cytokines

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Inhibitory　effects　of　Tetandrine　on　experimental　Anterior　Uveitis　Rabbits

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The Journal of Biomedical Research 1994年第1期18卷 44-44页

作者： Xiaon, Jigao,et, al. ACTA ACADeMIAe MeDICINAe NANJING,1994,14 (2):142-145

Anterior uveitis was induced by injection of lens protein into anterior chamber of rabbit *** (Tet) (50mg/kg ip) showed marked inhibition on this ocular inflammation, the total content of prostaglandin e in irises, and leukocyte *** pathological examination revealed that inflammation of irises in Tet group was lighter than that in control group. The antiinflammatory mechanism of Tet may be related to reduction of intracellular free calcium and inhibition of synthesis of inflmmatory factor.

关键词： tetrandrine anterior uveitis lens protein prostaglandin e rabbit

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