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proptosis in orbital myeloid sarcoma: A precursor to acute leukaemia

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Journal of Acute Disease 2017年第3期6卷 134-136页

作者： Fhun LC Tai ELM Wan-Hazabbah WH Liza-Sharmini AT Chong MF Department of Ophthalmology Hospital Raja Permaisuri BainunJalan Hospital30450IpohPerak Department of Ophthalmology School of Medical SciencesHealth Campus Universiti Sains Malaysia16150Kubang KerianKelantanMalaysia

Myeloid sarcoma is a rare, aggressive presentation of acute myeloid leukemia which tends to affect bones and soft tissue. It is usually seen in children, and has a poor prognosis. We report a case of orbital myeloid sarcoma presenting with unilateral proptosis in a young adult who subsequently developed acute myeloid leukaemia. An 18-year-old male presented with sudden, progressively increasing right eye swelling over two weeks. Examination revealed right eye proptosis, with a positive relative afferent papillary defect and a right eye visual acuity of 6/60, pinhole 6/18. The right fundus showed optic disc hyperemia, tortuous veins and choroidal folds. The left eye was normal. On initial examination, computed tomography (CT) of the brain and orbit showed an enhancing mass at the lateral aspect of the right orbit measuring 3.8 x 2.1 cm, with optic nerve displacement. Right lateral orbitotomy and excisional biopsy yielded a tissue diagnosis of myeloid sarcoma. The peripheral blood smear was normal at this time. The patient defaulted treatment but presented again three months later with right eye massive proptosis and loss of vision. A repeated CT scan showed a large lobulated mass measuring 104.5mm x 87.21mmm x 77.25mm occupying the right orbit, with destruction of the bony orbital walls and intracranial extension. A repeat full blood picture and bone marrow aspiration showed 30% blast cells, consistent with the diagnosis of acute myeloid leukemia. Patient was started on chemotherapy and radiotherapy. The tumour regressed after five cycles, but unfortunately, patient passed away due to brain metastases.

关键词： proptosis Leukemia Orbital myeloid sarcoma

A Rapidly Progressive proptosis, a Case Report

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Open Journal of Ophthalmology 2012年第2期2卷 37-39页

作者： Afshin Tajdini Mazen Sinjab Somer Hassan Department of Ophthalmology Al-Mouasat Hospital Damascus Syria.

In contrast to intraocular metastases, orbital metastases are a rare manifestation of systemic malignancies;such orbital metastases account for only 1% - 13% of all orbital tumors. Such tumors grow rapidly;they may undergo necrosis, as the rate of tumor angiogenesis cannot keep pace with the rapidly expanding mass. Here, we report a rare case of an orbital metastasis from a nasopharyngeal carcinoma.

关键词： proptosis Orbital Metastasis Nasopharyngeal Carcinoma Undifferentiated Carcinoma

Orbital liposarcoma: a retrospective, single-center study of thirteen patients

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1293-1298页

作者： Ning Gao Xin Ge Cheng Pei Jian-Min Ma Ya-Guang Hu Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To explore the clinical and pathological characteristics of thirteen patients with orbital ***:The clinical history data of thirteen patients diagnosed as orbital liposarcoma at Beijing Tongren Hospital,from 2006 to 2021 were collected and *** data includes age,gender,affected orbital side,course of disease,status of disease(primary or recurrent),clinical manifestations,preoperative visual acuity,operative treatment,the relations between liposarcoma and surrounding tissue,longest diameter of liposarcoma,histological subtype,immunohistochemical indicators,follow-up treatment and ***:The initial symptoms are *** is the most frequent chief complaint and the others included vision loss,epiphora,diplopia,and eyelid palpable *** of imaging examination[computed tomography(CT)or magnetic resonance imaging(MRI)]showed orbital *** terms of treatment,10 patients received tumor resection,and the mean longest diameter of the tumor was 3.39±1.36 *** other 3 patients had optic nerve invaded,so they received orbital *** examination results confirmed the diagnose of liposarcoma for 13 *** patients displayed as myxoid type,and three patients in each type of dedifferentiated and welldifferentiated *** patient was verified as pleomorphic,which was a rare type of *** of the patients showed Vimentin positive,and most showed CD34 and S-100 ***,four patients showed smooth muscle actin *** thirteen patients were ***:Orbital liposarcoma is a rare disease and it has no specific clinical *** diagnosis of liposarcoma should be considered when proptosis and orbital mass occurred in *** is recommended to perform pathological examination to achieve early detection and early treatment.

关键词： liposarcoma orbital tumor orbital mass proptosis

Bilateral scleromalacia perforans and peripheral corneal thinning in Wegener's granulomatosis

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International Journal of Ophthalmology(English edition) 2011年第4期4卷 439-442页

作者： S C Reddy I Tajunisah T Rohana Department of Ophthalmology Faculty of Medicine University of Malaya

A rare case of bilateral scleromalacia perforans, bilateral peripheral corneal thinning (contact lens cornea) and unilateral orbital inflammatory disease in a 50 year old female patient with an indolent form Wegener's granulomatosis(WG) involving lungs and sinuses is reported. The patient survived for 12 years after the initial diagnosis of systemic disease. There was perforation of left globe following trauma and no perforation of the right globe till the last follow up of the patient.

关键词： Wegener's granulomatosis scleromalacia perforans peripheral thinning of cornea proptosis

Orbital apex syndrome after tooth extraction in an immunocompromised patient

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International Journal of Ophthalmology(English edition) 2011年第1期4卷 112-114页

作者： Suresh Subramaniam Cheong Min Tet Wan Hazabbah Wan Hitam Adil Hussein Shamim Ahmed Khan Hillol Kanti Pal Zunaina Embong Department of Ophthalmology School of Medical SciencesUniversiti Sains MalaysiaHealth Campus Department of Ortorhinolaryngology School of Medical SciencesUniversiti Sains MalaysiaHealth Campus Department of Neurosciences School of Medical SciencesUniversiti Sains MalaysiaHealth Campus

A 60 year-old man presented with acute on set of left eye proptosis and ptosis. It was associated with poor vision, eye pain and restriction of eye movement of the same eye after 5 hours post left upper molar tooth extraction. The visual acuity in the left eye was hand movement. There was severe ptosis and proptosis of the left eye. The conjunctiva was chemotic with quite anterior chamber. The pupil was mid dilated and sluggished to light. The ocular movement was restricted in all directions. Fundoscopy of the left eye revealed features of central retinal artery occlusion with hyperaemic disc and subretinal exudates at posterior pole. The right eye appeared normal. Urgent MRI brain and orbit revealed severe left paranasal sinusitis with anterior displacement of the left globe and presence orbital abscess. Patient was managed with Otorhinolaryngology and Neurosurgery teams. He underwent emergency transnasal drainage of abscess. Histopathological examination of unhealthy sinus mucosa showed evidence of fungal infection. However, the culture and sensitivity result was inconclusive. Patient was treated with amphotericin B, ceftriaxone, amoxicillin clavulanate and metronidazole. Patient was detected to have high blood sugar level and was managed accordingly. The proptosis improved with treatment. However, his vision, ptosis and ophthalmoplegia remained static. Assessing the immunocompromised status is important for the management of patient presented as acute orbital apex syndrome to avoid fatal outcome.

关键词： orbital apex syndrome tooth extraction proptosis ptosis ophthalmoplegia

Aneurysmal Bone Cyst of the Orbit

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Chinese Medical Journal 2015年第4期128卷 562-563页

作者： Jian-Cang Wang Meng Zhang Xin-Xin Zhao Department of Ophthalmology Children's Hospital of Hebei Province Shijiazhuang Hebei 050000 China Department of Ophthalmology Fourth Hospital of Hebei Medical University Shijiazhuang Hebei 050011 China

Aneurysmal bone cyst （ABC） is an uncommon benign lesion with a reported incidence rate of 0.14 cases for every 1,000,000 *** can occur in any part of the skeletal system but is mainly detected in the long *** involvement is rare （〈1% of all ABCs）.In this article,we presented two female patients aged 49 and 33 years old respectively who suffered from *** successful surgical removal of the cyst via frontal craniotomy and simple curettage,the patients recovered well and have been in good health throughout the 2.5-4.5 years of follow-up.

关键词： Aneurysmal Bone Cyst Cranium Tumors Orbital Tumors proptosis

Sinonasal Squamous Papilloma with Orbital Infiltration in an Elderly Nigerian Female, Unusual Presentation of an Uncommon Tumor: A Case Report

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Case Reports in Clinical Medicine 2019年第5期8卷 134-139页

作者： Oyeleye A. Oyelakin Oluyemi Fasina Clement A. Okolo Funsho J. Akande Onyekwere G. Nworgu Department of Otorhinolaryngology University College Hospital Ibadan Nigeria Department of Ophthalmology University College Hospital University of Ibadan Ibadan Nigeria Department of Pathology University College Hospital University of Ibadan Ibadan Nigeria Department of Otorhinolaryngology University of Ibadan Ibadan Nigeria

Squamous papillomas are squamous-derived growths commonly arising from the oral cavity and oropharynx. A 75-year-old woman presented with chronic persistent left nasal obstruction and gradual painless non-axial proptosis with loss of vision in the left eye. Computed tomography scan showed an iso-dense lesion filling the frontal, left ethmoidal and sphenoidal sinuses, and the nasal cavity, with extension into the left orbit. She underwent surgical tumor resection with orbital exenteration and histology revealed features of an aggressive hyperkeratotic squamous papilloma arising from the sino-nasal region. Although squamous papillomas have been natively associated with the oral cavity and oropharynx, they present less frequently as sino-nasal tumors with orbital invasion.

关键词： Orbital Tumor Sino-Nasal Tumor proptosis Squamous Papilloma