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Global Protein Expression Analysis of Molecular Markers of DS-1-47,a Component of implantation-promoting Traditional Chinese Medicine

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 910-915页

作者： Yan-ling LI Xiao-yan ZHANG Yu LENG Yan-li WU Jing LI Yun-xia WU Department of Traditional Chinese Medicine School of Pharmacy Tongji Medical School Huazhong University of Science and Technology Wuhan 430030 China Department of Emergeney Hubei General Hospital of Chinese People ＂s Armed Police Forces Wuhan 430061 China

This study investigated the molecular markers of DS-1-47,a component of an implantation-promoting traditional Chinese medicine consisting of Astragalus mongholicus,Atractylodes macrocephala,Scutellaria baicalensis and Dipsacales,in an attempt to clarify the molecular mechanism and action targets of *** ovarian stimulation（COS） method was used to establish the implantation dysfunction models of *** were divided into normal pregnant group,COS model group and DS-1-47 *** capture microdissection-double dimensional electrophoresis-mass spectrum（LCM-DE-MS） was used to analyze the uterine protein molecules that were possibly involved in the promotion of ***-three proteins in DS-1-47 group were significantly changed as compared to those in COS model group,with 7 proteins down-regulated and 16 proteins *** for some constituent proteins,the down-regulated proteins included collagen α-1（Ⅵ） chain,keratin 7,keratin 14,myosin regulatory light chain 12 B,myosin light polypeptide 9,heat shock protein β-7,and C-U-editing enzyme APOBEC-2;the up-regulated proteins included apolipoprotein A-I,calcium regulated protein-3,proliferating cell nuclear antigen,L-xylulose reductase,and calcium binding *** 23 proteins that were regulated by DS-1-47 represented a broad diversity of molecule *** down-regulated proteins were associated with stress and immune response,and those up-regulated proteins were related to *** was suggested that these proteins were important in regulating the uterine environment for the blastocyst *** identification of DS-1-47 markers,proteomic analysis coupled with functional assays is demonstrated to be a promising approach to better understand the molecular mechanism of traditional Chinese medicine.

关键词： DS-1-47 promoting implantation proteomics LCM-DE-MS

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