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Study on the interactions of chlorpromazine hydrochloride and promethazine hydrochloride with nucleic acids by resonance Rayleigh scattering spectrum

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Science China Chemistry 2005年第6期48卷 591-599页

作者： LIU Shaopu HU Xiaoli LIU Zhongfang LI Ming WANG Fen School of Chemistry and Chemical Engineering Southwest China Normal UniversityChongqing 400715China

The interactions of phenothiazine such as chlorpromazine hydrochloride(CPZ·HCl)and promethazine hydrochloride(PZ·HCl),with nucleic acids(NA)have been *** CPZ-NA system can produce very intense resonance Rayleigh scattering(RRS),but the RRS intensity of the PZ-NA system is very *** energy relationship of the two reaction systems has been calculated by the AM1 and B3LYP of density functional methods for quantum chemistry,the binding site and interacting model of CPZ-NA and PZ-NA are *** results show that CPZ has strong binding ability with nucleic acids,but PZ hardly react with nucleic *** can be expected that RRS method may be a useful means for molecular recognition of nucleic acids and the molecular design of gene medicine in the ***,the method is used for the quan-titative determination of nucleic acids by employing chlorpromazine hydrochloride as reagent,which has very high sensitivity and good ***,a sensitive,simple and rapid new method has been developed for the determination of nucleic acids.

关键词： resonance Rayleigh scattering nucleic acid promethazine chlorpromazine interaction.

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promethazine-Tetraphenyl Boron(III) Modified Carbon Paste Electrode for the Determination of promethazine Hydrochloride

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American Journal of Analytical Chemistry 2013年第5期4卷 258-264页

作者： Sayed Sayed Badawy Sherif Abo El Seoud El Said Department of Chemistry Faculty of Science Cairo University Cairo Egypt

promethazine modified carbon paste ion selective electrode has been prepared, based on the ion pair of promethazine hydrochloride *** with sodium tetraphenyl boron(III) Pm-TPB dissolved in dioctyl phthalate DOP as a pasting liquid. The electrode showed the linear response with mean calibration graph slope of 58 mV/decade at 25℃;at a concentration range and a lower detection limit of 1 × 10-5 -6 × 10-2 M and 8 × 10-6 M promethazine hydrochloride, respectively. The change of pH of the tested solution within the range 4.2 -6.8 did not affect the electrode performance. The electrode showed a very good selectivity toward Pm+ cations with respect to a large number of organic and inorganic cations and compounds. The standard addition and potentiometric titration methods were applied for the determination of promethazine hydrochloride in pure solution and in pharmaceutical preparations with an?average recovery range of 97.3% -101.4% and a mean relative standard deviation (RSD) of 0.35% -1.83 % which were of comparable accuracy and precision to the previously reported works.

关键词： Carbon Paste Electrode Ion Pair promethazine Hydrochloride Phenergan (Syrup)

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Differences of promethazine and terfenadine on ion channels in guinea pig ventricular myocytes

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Chinese Medical Journal 2006年第11期119卷 944-947页

作者： LI Xue-wen NIU Shuan-cheng ZHANG Xuan-ping Lü Ji-yuan BAI Feng ZHANG Ling WU Bo-wei First Hospital Shanxi Medical University Taiyuan 030001China Department of Pharmacology Shanxi Medical University Taiyuan 030001China Department of Physiology Shanxi Medical University Taiyuan030001China

promethazine, a first generation antihistamine,has an antiarrhythmic effect on ischemia-reperfusion inducing arrhythmias^1 and experimental arrhythmias.^2 However, terfenadine as a second generation of antihistamine, has been reported to elicit hypotension, bradycardia, prolongation of the QTc interval and torsades de pointes （TdP） like ventricular arrhythmia.^3 This may be due to the blockage on rectifier postassium current （Ik） of terfenadine, resulting in the prolongation of the action potential duration （APD） and dispersion of the repolarization duration, which might provoke a specific form of polymorphic ventricular tachydysrhythmia, i.e. TdP.^4 In clinical practice,however, the class Ⅲ antiarrhythmic agents, which target on the lk and prolong the action potential duration and QTc interval, rarely lead to *** actions must be considered to underlie the arrhythmogenic tendency of terfenadine besides its inhibition on Ik. Though both promethazine and terfenadine block the H1 receptor, there must be a different pharmacology profile between the two compounds on ion channels of cardiac ***-cell patch clamp technique was used to investigate the effects of these two antagonists of the H1 receptor on the main ion currents in cardiac electrical activities.

关键词： promethazine terfenadine ion channels ventricular myocytes H1 receptor

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The effects of promethazine on the analgesia,hypnosis,amnesia and therapeutic index of isoflurane treated mice

The effects of promethazine on the analgesia,hypnosis,amnesi...

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全国第一次麻醉药理学术会议暨中国药理学会麻醉药理专业委员会筹备会

作者： Su-pei Song~1 Liu-qing Hu~1 Ti-jun Dai~2 (1.Institute of Anesthesiology,2.Jiangsu Province Key Laboratory of Anesthesiology,Xuzhou Medical College,Xuzhou,PRChina)

The present study was designed to investigate the effects of promethazine on the analgesia, hypnosis,amnesia and therapeutic index of *** study promethazine on the analgesic effect of isoflurane with hot-plate test and writhing *** studying the effect of promethazine on the sleeping time of isoflurane,we use the righting reflex *** established the mouse model of the effect of promethazine on the amnesia of isoflurane by Morris water *** method provided the statistics for the ED、LD in *** result of hot-plate test and writhing test indicated that promethazine could enhance the analgesic effect of isoflurane(Ppromethazine(Ppromethazine can potentialize the amnesia of isoflurance in the Morris water maze by space exploration tests and directional navigation tests(Ppromethazine could decrease the ED of isoflurance(P0.05).These results suggested that promethazine could not only reinforce the effect of isoflurance on analgesia、hypnosis and amnesia,but also boost the therapeutic index of isoflurance.

关键词： promethazine Isoflurane Analgesia Hypnosis Amnesia Therapeutic index Anesthesia

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Role of Histamine H1 Receptors in Vestibular Nucleus in Motion Sickness

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Journal of Otology 2011年第1期6卷 20-25页

作者： HUANG Li-gui WANG En-tong CHEN Wei GONG Wei-xi Department of Otolaryngology-Head and Neck Surgery Lushan Hospital of PLA Jiujiang 332000 China Department of Otolaryngology-Head and Neck Surgery General Hospital of Air Force Beijing 100142 China

Objectives To investigate the expression of histamine H1 receptors （H1R） in the vestibular nucleus of brainstem in rats and the role of H1R in motion sickness （MS）. Methods A total of 24 healthy Sprague-Dawley rats were divided randomly into four groups （n=6 each） which determined if the animals would receive induction of MS or drug （promethazine） treatment： MS （ - ）/Drug （ - ）; MS（＋）/Drug （ - ）; MS （ - ）/Drug （＋ at 0.25 mg）; and MS （＋）/ Drug（＋）. MS was induced by complex motion stimulation and the conditioned taste aversion was used as a behavioral indicator of MS. The volume of 0.15% sodium saccharin solution （SS） intake within 45 minutes after motion stimulation was measured. H1R in the vestibular nucleus was examined by immunofluorescence staining. The expression of H 1R protein in brainstem tissue at vestibular nucleus level was detected by western blot. Results The mean SS intake volume in the MS （＋）/Drug （ - ） group （8.8 ml） was significantly less than that of the MS （ - ）/Drug （ - ） group （15.1 ml）（P 〈 0.01）. The mean SS intake volume of the MS （-）/Drug （＋） group （14.8 ml） was similar to that of the MS（-）/Drug（-） group. The mean SS intake volume （9.6 ml） of the MS（＋）/Drug（＋） group was more than that of the MS（＋）/Drug（-）group （P〈0.01）, but less than that of the MS（-）/Drug（-） group or MS（-）/Drug（＋） group （P 〈 0.01）. Immunofluorescence staining showed positive expression of H1R in the vestibular nucleus of brainstem and the expression was enhanced by motion stimulation. Western blot analysis showed that H1R protein expressed in the brainstem tissue at vestibular nucleus level and the expression also increased significantly after motion stimulation. The MS-induced increase of H1R was not affected significantly by promethazine. Conclusions H1Rs exist in the vestibular nucleus in rats and H 1R expression is up-regulated by motion stimulation, but not affected by promethazine. The findings indicate that the histaminergic system is involved in MS. promethazine

关键词： motion sickness histamine H1 receptor vestibular nucleus promethazine rat

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