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prognostic factors and survival after surgical resection of pancreatic neuroendocrine tumor with validation of established and modified staging systems

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Hepatobiliary & Pancreatic Diseases International 2018年第2期17卷 169-175页

作者： Nikolaos Benetatos James Hodson Ravi Marudanayagam Robert P Sutcliffe John R Isaac John Ayuk Tahir Shah Keith J Roberts The HPB Unit Queen Elizabeth Hospital Birmingham University Hospitals Birmingham NHS Foundation Trust Institute of Translational Medicine Queen Elizabeth Hospital Birmingham University Hospitals Birmingham Endocrinology Queen Elizabeth Hospital Birmingham University Hospitals Birmingham Liver Unit Queen Elizabeth Hospital Birmingham University Hospital of Birmingham NHS Foundation Trust

Background: Pancreatic neuroendocrine tumors(PNETs) display wide heterogeneity with highly variable prognosis. This study aimed to identify variables related to survival after surgical resection of ***: A total of 143 patients were identified from a prospectively maintained database. Patient characteristics were analyzed and prognostic factors for overall survival and progression-free survival were evaluated. The WHO, ENETS and AJCC scoring systems were applied to the cohort, and their ability to predict patient outcomes were ***: Multivariate analysis found that female gender, lymph node metastases and increasing WHO2010 grade to be independently associated with reduced overall survival(P < 0.05). Patients requiring multi-visceral resection or debulking surgery found to be associated with shortest survival. ROC analysis found the ENETS and AJCC scoring systems to be similarly predictive of 5-year overall survival. Modified Ki67 significantly improved its accuracy in predicting 5-year overall survival(AUROC: 0.699 vs 0.605;P < 0.01).Conclusions: Multi-visceral or debulking surgery is associated with poor outcomes. There seems to be no significant difference between enucleation and anatomical segmental resection. Available scoring systems have reasonable accuracy in stratifying disease severity, with no system identified as being *** stratification with modified grading systems needs further validation before applied in clinical practice.

关键词： Pancreatic neuroendocrine tumors prognostic factors Validation of staging systems

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prognostic factors for overall survival in prostate cancer patients with different site-specific visceral metastases: A study of 1358patients

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World Journal of Clinical Cases 2020年第1期8卷 54-67页

作者： Peng-Fei Cui Xiao-Feng Cong Feng Gao Jia-Xin Yin Zi-Ru Niu Song-Chen Zhao Zi-Ling Liu Cancer Center the First Hospital of Jilin University

BACKGROUND Distant metastasis,particularly visceral metastasis(VM),represents an important negative prognostic factor for prostate cancer(PCa)***,due to the lower rate of occurrence of VM,studies on these patients are relatively ***,studies focusing on prognostic factors associated with PCa patients with VM are highly *** To investigate the prognostic factors for overall survival(OS)in PCa patients with lung,brain,and liver metastases,respectively,and evaluate the impact of site-specific and number-specific VM on *** Data on PCa patients with VM were extracted from the Surveillance,Epidemiology,and End Results database between 2010 and *** and multivariate Cox regression analyses were used to analyze the association between clinicopathological characteristics and survival of patients with different site-specific ***-Meier analyses and Log-rank tests were performed to analyze the differences among the *** A total of 1358 PCa patients with site-specific VM were identified from 2010 to *** age(>70 years)(P8)(Pprognostic factors associated with poor OS in PCa patients with lung *** stage(T3/T4)(P=0.047)was noted to be the only independent risk factor affecting OS in PCa patients with brain *** age(>70 years)(P=0.010)and higher Gleason score(>8)(P=0.001)were associated with shorter OS in PCa patients with liver *** patients with isolated lung metastases exhibited significantly better survival outcomes compared with PCa patients with other single sites of VM(Pprognostic factors affecting OS in PCa patients with different si

关键词： prognostic factors Overall survival Prostate cancer Visceral metastases

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prognostic factors and therapeutic effects of different treatment modalities for colorectal cancer liver metastases

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1177-1194页

作者： Zuo-Hong Ma Yong-Peng Wang Wen-Heng Zheng Ji Ma Xue Bai Yong Zhang Yuan-He Wang Da Chi Xi-Bo Fu Xiang-Dong Hua Department of Hepatopancreatobiliary Surgery Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina Department of Medical Imaging Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina Department of Pathology Cancer Hospital of China Medical UniversityLiaoning Cancer Hospital and InstituteShenyang 110042Liaoning ProvinceChina

BACKGROUND Colorectal cancer(CRC)is one of the most common malignant tumors in China,and the liver is the most common metastatic site in patients with advanced *** is the gold standard treatment for colorectal liver *** patients who cannot undergo radical resection of liver metastases for various reasons,ablation therapy,interventional therapy,and systemic chemotherapy can be used to improve their quality of life and prolong their survival *** To explore the prognostic factors and treatments of liver metastases of *** A retrospective analysis was conducted on 87 patients with liver metastases from CRC treated at the Liaoning Cancer Hospital and Institute between January 2005 and March *** to different treatments,the patients were divided into the following four groups:Surgical resection group(36 patients);ablation group(23 patients);intervention group(15 patients);and drug group(13 patients).The clinicopathological data and postoperative survival of the four groups were *** Kaplan-Meier method was used for survival analysis,and the Cox proportional hazards regression model was used for multivariate *** The median survival time of the 87 patients was 38.747±3.062 mo,and the 1-and 3-year survival rates were 87.5%and 53.1%,*** Cox proportional hazards model showed that the following factors were independent factors affecting prognosis:The degree of tumor differentiation,the number of metastases,the size of metastases,and whether the metastases are close to great *** results of treatment factor analysis showed that the effect of surgical treatment was better than that of drugs,intervention,or ablation alone,and the median survival time was 48.83±4.36 *** drug group had the worst prognosis,with a median survival time of only 13.5±0.7 mo(P<0.05).For patients with liver metastases of CRC near the great vessels,the median survival time(27.3 mo)of patients undergoing surgical resecti

关键词： Colorectal cancer Liver metastasis prognostic factors Ablation Surgical resection Retrospective study

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prognostic factors and predictors of postoperative adjuvant transcatheter arterial chemoembolization benefit in patients with resected hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第10期26卷 1042-1055页

作者： Ming-Yu Chen Sarun Juengpanich Jia-Hao Hu Win Topatana Jia-Sheng Cao Chen-Hao Tong Jian Lin Xiu-Jun Cai Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Engineering Research Center of Cognitive Healthcare of Zhejiang Province Hangzhou 310000Zhejiang ProvinceChina Department of General Surgery Shaoxing People’s HospitalZhejiang UniversityShaoxing 312000Zhejiang ProvinceChina Department of General Surgery Longyou People’s HospitalQuzhou 314400Zhejiang ProvinceChina

BACKGROUND Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) has improved overall survival (OS) in patients with hepatocellular carcinoma (HCC).However,the prognostic and predictive factors remain *** To assess the prognostic factors and the predictors of PA-TACE benefit for OS in patients with resected *** Univariate and multivariate analyses were performed to identify the potential prognostic factors for *** order to assess the predictive factors of PA-TACE benefit,the interaction variables between treatments for each subgroup were evaluated using the Cox proportional hazards regression *** A total of 378 patients (PA-TACE vs surgery alone,189:189) from three centerswere included after a propensity-score 1:1 matching *** to the group receiving surgery alone,PA-TACE prolonged the OS rate in patients with resected HCC (P prognostic factors for OS in both *** (P=0.023) and microscopic vascular invasion (MVI)(P=0.002) were also identified in the PA-TACE group,while gender (P=0.027),hepatitis B virus(P=0.034) and albumin-bilirubin grade (P=0.027) were also selected in the surgery alone *** addition,PA-TACE resulted in longer OS than surgery alone across subgroups [all hazard ratios (PA-TACE-to-surgery alone)prognostic factors for ***,high FHR and the absence of MVI were important predictive factors,which can be used to assist clinicians in selecting which patients could achieve a better OS with PA-TACE.

关键词： Postoperative adjuvant transcatheter arterial chemoembolization Hepatocellular carcinoma prognostic factors Predictive factors Overall survival

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prognostic factors related with survival in patients with pancreatic adenocarcinoma

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World Journal of Gastroenterology 2014年第31期20卷 10802-10812页

作者： Ahmet Bilici Department of Medical Oncology Medical Faculty Istanbul Medipol University

The prognosis in patients with pancreatic cancer is poor and this cancer is the fourth leading cause of cancer-related death worldwide. Although surgical resection is the only curative treatment of choice for pancreatic cancer, the majority of patients are diagnosed at an advanced stage, thus only 10%-15% of them are suitable for curative resection and the overall survival is less than 5%. Chemotherapy for metastatic disease is to palliate symptoms of patients and to improve survival. Therefore, prognostic factors are important and a correct definition of poor prognostic factors may help to guide more aggressive adjuvant or aggressive treatment protocols in patients with pancreatic cancer. This article reviews the prognostic factors affecting survival of patients with pancreatic cancer in the light of recent advances in the literature.

关键词： Pancreatic cancer prognostic factors Survival Carbohydrate antigen 19-9 Treatment

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Bone metastases from hepatocellular carcinoma:clinical features and prognostic factors

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 499-505页

作者： Yang Lu Jin-Gen Hu Xiang-Jin Lin Xi-Gong Li Department of Orthopedics First Affiliated HospitalZhejiang University School of Medicine Hangzhou 310003 China

BACKGROUND: Bone metastases (BMs) from hepatocellular carcinoma (HCC) is an increasingly common disease in Asia. We assessed the clinical features, prognostic factors, and differences in outcomes related to BMs among patients with different treatments for HCC. METHODS: Forty-three consecutive patients who were diagnosed with BMs from HCC between January 2010 and December 2014 were retrospectively enrolled. The clinical features were identified, the impacts of prognostic factors on survival were statistically analyzed, and clinical data were compared. RESULTS: The median patient age was 54 years; 38 patients were male and 5 female. The most common site for BMs was the trunk (69.3%). BMs with extension to the soft tissue were found in 14 patients (32.5%). Most (90.7%) of the lesions were mixed osteolytic and osteoblastic, and most (69.8%) patients presented with multiple BMs. The median survival after BMs diagnosis was 11 months. In multivariate analyses, survival after BM diagnosis was correlated with Karnofsky performance status (P=0.008) and the Child-Pugh classification (Pprognostic factors of survival after diagnosis of BMs were the Karnofsky performance status and Child-Pugh classification. HCC patients developed BMs may also benefit from liver transplantation or hepatectomy.

关键词： hepatocellular carcinoma bone metastases survival prognostic factors

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Clinical characteristics and prognostic factors of patients with mature T-cell lymphoid malignancies： a single-institution study of 225 cases

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Frontiers of Medicine 2015年第4期9卷 468-477页

作者： Wen Xue Yan Sheng Xiangqin Weng Yongmei Zhu Yan Zhao Pengpeng Xu Xiaochun Fei Xiaoyan Chen Li Wang Weili Zhao State Key Laboratory of Medical Genomics Shanghai Institute of Hematology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Pathology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Mature T-cell lymphoid malignancies comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow （BM） infiltration is more commonly present in mature T-cell lymphoid malignancies compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 patients with mature T-cell lymphoid malignancies treated in a single institution. These included 29 cases of T-cell lymphoproliferative disorders （T-LPD, all with BM infiltration） and 196 cases of T-/natural-killer-cell lymphoma （T/NKCL, 56 with BM infiltration and 140 without BM infiltration）. The estimated 5-year overall survival （OS） rates of T-LPD and T/NKCL were 96.6% and 37.3%, respectively. T-LPD patients were less likely to exhibit poor performance status, advanced disease stage, presence of B symptoms, or abnormal level of serum [^-2 microglobulin. With similar pathological characteristics, T/NKCL patients with BM infiltration showed significantly lower response rates and shorter OS than those without BM infiltration （P = 0.0264 and P 〈 0.0001, respectively）. Multivariate analysis indicated that poor performance status, advanced disease stage, elevated serum lactate dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow prognostic Score may be more efficient than the International prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying patients with mature T-cell lymphoid malignancies.

关键词： mature T-cell lymphoid malignancies clonal T-cell population bone marrow infiltration prognostic factors

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Combined vascular resection and analysis of prognostic factors for hilar cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2015年第6期14卷 626-632页

作者： Shu-Tong Wang Shun-Li Shen Bao-Gang Peng Yun-Peng Hua Bin Chen Ming Kuang Shao-Qiang Li Qiang He Li-Jian Liang Department of Hepatic Surgery First Affiliated HospitalSun Yat-Sen University

BACKGROUND： Hilar cholangiocarcinoma （HCCA） is a devastating malignancy arising from the bifurcation of the hepatic duct, whether combined vascular resection benefits HCCA patients is controversial. This study was undertaken to assess the effect of combined vascular resection in HCCA patients and to analyze the prognostic factors.

关键词： hilar cholangiocarcinoma hepatic artery resection portal vein resection prognostic factors

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prognostic factors of Gastrointestinal Stromal Tumors： A Single Institutional Retrospective Experience with Surgical Management over 20 Years

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Clinical oncology and cancer researeh 2010年第3期7卷 175-180页

作者： Yong-kai WU Dong-bing ZHAO Cheng-feng WANG Jian-qiang CAI Yong-fu SHAO Ping ZHAO Department of Abdominal Surgical Oncology Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 China.

OBJECTIVE To analyze the pathological features and prognosis factors of gastrointestinal stromal tumor （GIST） after primary resection. METHODS Medical records of the diagnosis, surgery, and follow-up of 327 patients with GISTs who underwent surgery between 1988 and 2007 were retrospectively reviewed. The predic-tive factors for the survival of these patients were identi. ed using multivariate analysis. RESULTS In the 327 tumors, 152 （46.5%） were located in the stomach, 89 （27.2%） in the small intestine, 33 （10.1%） in the colon and rectum, and 43 （13.1%） in other sites including the omentum and mesentery. The 3-year and 5-year overall survival rates of the 327 GIST patients were 74.4% and 62.7%, respectively, and univariate survival analysis demonstrated that factors, such as tumor size, mitotic index, NIH categories, Ki-67 index, tumor location, surgical margins, tumor bleeding, and tumor necrosis have significant effect on survival of the patients （P 〈 0.05）. Multivariate analysis demonstrated that the NIH categories, surgical margins, and Ki-67 index were independent prognostic factors for the survival rate. In the group of patients with postoperative recurrence or metastasis, the median survival time of patients who did not receive imatinib treatment was 30 months and that of patients who received imatinib treatment was 59 months. Their 5-year survival rates were 16.4% and 39.4%, respectively, and the difference was statistically significant （P = 0.017）. CONCLUSION Complete resection is the .rst choice of treat-ment for GISTs. It is reasonable to evaluate the prognosis of resect-able GISTs and guide the adjunctive therapy with NIH categories and Ki-67 index. Imatinib treatment can *** increase the survival rate of patients with recurrent and metastatic GISTs.

关键词： gastrointestinal stromal tumors prognostic factors surgical management survival adjuvant therapy

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The survival and prognostic factors of primary testicular lymphoma- two-decade single-center experience

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Asian Journal of Andrology 2018年第6期20卷 615-620页

作者： Run-Zhuo Ma Lei Tian Li-Yuan Tao Hui-Ying He Min Li Min Lu Lu-Lin Ma Hui Jiang Jian Lu Department of Urology Peking University Third Hospital Beijing 100191 China Department of Hematology Peking University Third Hospital Beijing 100191 China Department of Biostatistics Peking University Third Hospital Beijing 100191 China Department of Pathology Peking University Third Hospital Beijing 100191 China

This study aims to investigate the effect of different local testicular treatments and validate common prognostic factors on primary testicular lymphoma （PTL） patients. We retrospectively reviewed the clinical records of 32 patients from 1993 to 2017 diagnosed with PTL and included 22 patients for analysis. The Kaplan-Meier method, Log-rank test, and multivariate Cox proportional hazard regression analysis were applied to evaluate progression-free survival （PFS）, overall survival （OS）, and determine prognosis predictors. The median follow-up time was 30 months. Median OS and PFS were 96 months and 49 months, respectively. In univariate analysis, advanced Ann Arbor stage （Ill/IV）（P 〈 0.001）, B symptoms （P 〈 0.001）, and extranodal involvement other than testis （P = 0.001） were significantly associated with shorter OS and PFS. In multivariate analysis, Ann Arbor stage was significantly associated with OS （OR = 11.58, P = 0.049）, whereas B symptom was significantly associated with PFS （OR = 11.79, P = 0.049）. In the 10 patients with the systemic usage of rituximab, bilateral intervention could improve median OS from 16 to 96 months （P = 0.032）. The study provides preliminary evidence on bilateral intervention in testes in the rituximab era and validates common prognostic factors for Chinese PTL patients.

关键词： local treatment modalities prognostic factors prophylaxis contralateral orchiectomy prophylaxis contralateral radiotherapy testicular lymphoma

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