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Role of gastrin-peptides in Barrett's and colorectal carcinogenesis

World Journal of Gastroenterology 2012年第45期18卷 6560-6570页

作者： Eduardo Chueca Angel Lanas Elena Piazuelo IIS Aragon Aragon Institute of Health Sciences50009 ZaragozaSpain Networked Biomedical Research Center Hepatic and Digestive Diseases(CIBERehd) C/Corcega 180 bajos dcha08036 BarcelonaSpain Department of Medicine Psychiatry and DermatologyMedical University of ZaragozaC/Domingo Miral50009 ZaragozaSpain Service of Gastroenterology Hospital Clinico UniversitarioAvda.San Juan Bosco 1550009 ZaragozaSpain

Gastrin is the main hormone responsible for the stimulation of gastric acid secretion;in addition,gastrin and its derivatives exert proliferative and antiapoptotic effects on several cell *** synthesis and secretion are increased in certain situations,for example,when proton pump inhibitors are *** impact of sustained hypergastrinemia is currently being *** vitro experiments and animal models have shown that prolonged hypergastrinemia may be related with higher cancer rates;although,this relationship is less clear in human *** gastrin levels have been shown to cause hyperplasia of several cell types;yet,the risk for developing cancer seems to be the same in normo-and hypergastrinemic *** tumors also produce their own gastrin,which can act in an autocrine manner promoting tumor *** cancers are extremely dependent on gastrin to *** research focused only on the effects of amidated gastrins,but there has been an interest in intermediates of gastrin in the last few *** intermediates aren't biologically inactive;in fact,they may exert greater effects on proliferation and apoptosis than the completely processed *** certain gastrin overproduction states,they are the most abundant gastrin peptides *** purpose of this review is to examine the gastrin biosynthesis process and to summarize the results from different studies evaluating the production,levels,and effects of the main forms of gastrin in different overexpression states and their possible relationship with Barrett's and colorectal carcinogenesis.

关键词： Gastrin progastrin Glycine-extended gas-trins C-terminal flanking peptide Hypergastrinemia,Proton pump inhibitors Colorectal cancer Esophagealadenocarcinoma Barrett's esophagus

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Gastrin as an autocrine growth factor in colorectal carcinoma:implications for therapy

引用

World Journal of Gastroenterology 1998年第6期4卷 6-8页

作者： Graham S. Baldwin and Arthur Shulkes

Ｔｈｅｒｅｉｓｎｏｗｃｏｎｓｉｄｅｒａｂｌｅｅｘｐｅｒｉｍｅｎｔａｌｓｕｐｐｏｒｔｆｏｒｔｈｅｈｙｐｏｔｈｅｓｉｓｔｈａｔｐｒｏｇａｓｔｒｉｎｄｅｒｉｖｅｄｐｅｐｔｉｄｅｓｓｔｉｍｕｌａｔｅｐｒｏｌｉｆｅｒａｔｉｏ... 详细信息

Ｔｈｅｒｅｉｓｎｏｗｃｏｎｓｉｄｅｒａｂｌｅｅｘｐｅｒｉｍｅｎｔａｌｓｕｐｐｏｒｔｆｏｒｔｈｅｈｙｐｏｔｈｅｓｉｓｔｈａｔｐｒｏｇａｓｔｒｉｎｄｅｒｉｖｅｄｐｅｐｔｉｄｅｓｓｔｉｍｕｌａｔｅｐｒｏｌｉｆｅｒａｔｉｏｎｏｆｔｈｅｎｏｒｍａｌｃｏｌｏｎ...

关键词： Autocrine loop colorectal neoplasms gastrin gastrin receptor progastrin

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