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Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts

Asian Pacific Journal of Tropical Biomedicine 2013年第5期3卷 358-366页

作者： Khalid Algariri Kuong Y Meng Item J Atangwho Mohd Z Asmawi Amirin Sadikun Vikneswaran Murugaiyah Norhyati Ismail School of Pharmaceutical Sciences Universiti Sains Malaysia Department of Biochemistry College of Medical SciencesUniversity of Calabar

Objective:To study the antidiabetic activity of Gynura procumbens(***)used in the traditional management of diabetes in Southern ***:*** leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7 h),subcutaneous glucose tolerance test and sub-chronic(14 d)test in non-diabetic and streptozotocin-induced diabetic *** extracts were further subjected to phytochemical ***:In acute dose(1 g/kg),the extracts significantly lowered fasting blood glucose(FBG)in streptozotocin-induced diabetic rats(P<0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2 h)and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P<0.05),comparable only to the effect of ***,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25%extracts,and metformin sustained the decrease until the 90th min(P<0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P<0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction *** composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-nrtinoside)followed a similar ***:*** contains antidiabetic principles,most extracted in 25%*** among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism.

关键词： Antidiabetic Gynura procumbens Fasting blood glucose Subcutaneous glucose tolerance test Streptozotocin-induced diabetes Flavanoids Phenolics

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Effect of combination of Gynura procumbens aqueous extract and Trigona spp. honey on fertility and libido of streptozotocin-induced hyperglycaemic male rats

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Asian pacific Journal of Reproduction 2019年第2期8卷 56-62页

作者： Khaidatul Akmar Mahanem Mat Noor Centre for Biotechnology and Functional Food Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangiSelangorMalaysia

Objective: To study the effects of co-administration of Gynura procumbens (GP) and kelulut honey (KH) on male fertility and libido in diabetes-induced rats. Methods: A total 42 males Sprague Dawley rats aged 8 weeks were randomly and equally divided into six different groups. All groups except a normal control group were induced with 50 mg/kg of streptozotocin (STZ) intravenously to induce diabetes. A positive control group was treated with an antidiabetic drug, metformin (500 mg/kg) whereas a negative control group remained untreated throughout the experiment. Meanwhile, another three treatments on diabetic rat groups were performed and categorised as Group 1 (450 mg/kg GP+ 300 mg/kg KH), Group 2 (450 mg/kg GP + 600 mg/kg KH) and Group 3 (450 mg/kg GP+ 1200 mg/kg KH). Treatments were given for seven consecutive days through oral gavage and all rats were euthanized on day 8th for fasting blood glucose analysis, sperm quality, spermatogenesis, sexual behaviour and implantation sites analysis. Results: Fasting blood glucose levels were significantly reduced after treatment of GP and KH, compared to negative and positive controls. The treated groups showed significant increment in sperm quality compared to all control groups. Testes histology illustrated significant damages on leydig and sertoli cells for both negative and positive controls. On the contrary, co-administration of GP and KH displayed regeneration of leydig and sertoli cells in the testes. Additionally, the number of implantation sites significantly increased in females copulated with treated groups, compared to controls. Besides, the libido analysis displayed improvement of libido in treated groups, compared to all controls. Throughout the study, insignificant variances were recorded between the treated groups, indicating that treatment in Group 1 was sufficient to trigger significant improvement on fasting blood glucose level, fertility, and libido in diabetic male rats. Conclusions: Co-administration o

关键词： Diabetes mellitus Gynura procumbens Trigona spp. Honey Sperm quality Spermatogenesis

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Anatomical variation of five plant species along an elevation gradient in Mexico City basin within the Trans-Mexican Volcanic Belt, Mexico

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Journal of Mountain Science 2017年第11期14卷 2182-2199页

作者： P Mayte S.JIMéNEZ-NORIEGA Teresa TERRAZAS Lauro LóPEZ-MATA Arturo SáNCHEZ-GONZáLEZ Heike VIBRANS Department of Botany Postgraduate College at Campus Montecillo Institute of Biology Autonomous National University of Mexico Center of Biological Research Autonomous University of State of Hidalgo Mineral de la Reforma

Change in environmental conditions with altitudinal gradients induces morpho-anatomical variations in plants that have been poorly documented in intertropical regions. Five species with three life forms, cryptophyte(Alchemilla procumbens, Geranium seemannii), hemicryptophyte(Acaena elongata, Lupinus montanus), and phanerophyte(Symphoricarpos microphyllus), distributed along an altitudinal gradient in the Sierra Nevada of central Mexico, were studied. The aims were to identify and evaluate their morpho-anatomical modifications under the hypothesis that the sizes of individuals and of their wood and leaf cell types decrease as elevation increases. Three individuals per species per site were collected at seven locations along the altitudinal gradient(2949-3952 m). Their morpho-anatomical characters were analyzed through multiple regression analyses. Elevation was the variable that best explained anatomical changes in the leaf and wood ofthe five species. Canopy density and potassium content in the soil also contributed to explain the variation in anatomical variables along the gradient. As elevation increased a bimodal pattern was observed in various anatomical characters as in the leaf width of A. elongata, A. procumbens and G. seemannii and in the vessel diameter of A. procumbens, G. seemannii, and L. montanus. Other features as the vessel diameter of A. elongata, the fiber length of S. microphyllus, and the ray width of A. elongata increased as the elevation increased. Anatomical traits have a tendency to decrease in size but just toward the end of the gradient, which is probably related to changes in canopy density. The plant response to the altitudinal gradient is more focused on anatomical adaptations than morphological variation; it is also species dependent.

关键词： Altitude Foliar anatomy Mount Tlaloc Wood anatomy Alchemilla procumbens Geraniumseemannii Cryptophyte Bimodal pattern

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梵天花的生药学研究

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中草药 2005年第6期36卷 923-925页

作者：姜建萍廖月葵李莹广西中医学院药学院广西南宁530001

梵天花,别名狗脚迹、地桃花、三角枫、三合枫、拦路虎、八大锤等,为锦葵科植物梵天花Urenaprocumbens L.的全草,分布于浙江、江西、福建、台湾、湖南、海南、广东、广西等地的山坡、原野、村边、路旁[1].本品甘、苦、平,具有解毒消肿、... 详细信息

梵天花,别名狗脚迹、地桃花、三角枫、三合枫、拦路虎、八大锤等,为锦葵科植物梵天花Urenaprocumbens L.的全草,分布于浙江、江西、福建、台湾、湖南、海南、广东、广西等地的山坡、原野、村边、路旁[1].本品甘、苦、平,具有解毒消肿、散瘀止痛、化痰止咳、祛风利湿的功效.主治风湿痹痛、泄泻、痢疾、感冒、咽喉肿痛、肺热咳嗽、风毒流注、疮疡肿痛、跌打损伤、毒蛇咬伤[2,3].笔者对其药材性状,显微特征进行了研究,为其开发利用提供了科学的鉴定依据.……

关键词：生药学研究天花 procumbens 解毒消肿散瘀止痛化痰止咳祛风利湿风湿痹痛咽喉肿痛肺热咳嗽疮疡肿痛跌打损伤毒蛇咬伤药材性状显微特征鉴定依据地桃花锦葵科开发利

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以LC-DAD-MS/SPE-NMR联用技术鉴定南非钩麻中异环烯醚萜苷同分异构体

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国外医药（植物药分册） 2006年第1期21卷 29-30页

作者： Seger C[英] 汤树良（摘）

南非钩麻Harpagophytum procumbens DC.的镇痛、抗炎作用与其次生代谢产物中环烯醚萜苷和苯丙醇苷衍生物的结构多变有关。作者采用LC-DAD-MS/SPE-NMR联用技术对该植物根中微量的异环烯醚萜苷进行了检测。[第一段]

关键词：环烯醚萜苷南非钩麻同分异构体 Harpagophytum 技术鉴定 procumbens 次生代谢产物抗炎作用联用技术衍生物

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钩果草:从非洲传统草药到现代抗风湿药

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国外医药（植物药分册） 2001年第4期16卷 139-142页

作者：国植徐莉天津药物研究院天津300193

钩果草系非洲传统草药。大量临床研究表明,钩果草的干燥块茎及其提取物在减轻各种骨关节病、风湿病患者的疼痛、提高他们的能动性、改善生活质量方面是安全、有效的。德国 Com-mission E 和欧洲植物治疗科学联盟分别发表专论,承认钩果... 详细信息

钩果草系非洲传统草药。大量临床研究表明,钩果草的干燥块茎及其提取物在减轻各种骨关节病、风湿病患者的疼痛、提高他们的能动性、改善生活质量方面是安全、有效的。德国 Com-mission E 和欧洲植物治疗科学联盟分别发表专论,承认钩果草次生块茎及其提取物的临床抗风湿病功效,并批准作为上述疾病常规治疗的辅助治疗手段。

关键词：钩果草环烯醚萜风湿病 Harpagophytum procumbens Devil's Claw

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