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Efficacy of probiotics supplementation in amelioration of celiac disease symptoms and enhancement of immune system

World Journal of Clinical Cases 2023年第32期11卷 7741-7744页

作者： Mostafa Hossam-Eldin Moawad Ibraheem M Alkhawaldeh Abdulqadir J Naswhan Department of Clinical Faculty of PharmacyAlexandria UniversityIsmailiaEgypt Faculty of Medicine Mutah UniversityKarak 61710Jordan Nursing Department Hamad Medical CorporationDoha 3050Qatar

Patients with celiac disease(CD)have a mucosal layer that is unable to regulate the gut microbiota,leaving the host vulnerable to dangerous infections and *** compared to healthy people,this dysbiosis is marked by a decrease in intra-and intergeneric biodiversity,which demonstrates an imbalance between helpful bacteria and possibly harmful or proinflammatory *** early gut microbiota is influenced by the genotype of newborns with the HLADQ2 haplotypes,and this may modify how gluten is handled in the intestinal lumen,polarize innate or adaptive immune responses,and result in glutensensitive *** outcome of gluten digestion can vary depending on the composition of the intestinal gut bacteria and the partial conversion of gluten into peptides larger than ten amino acids in the small intestines,which can be *** the small intestine,114 different bacterial strains belonging to 32 different species have 27 of them exhibiting peptidolytic ***,the individual risk of developing a gluten-related illness is further influenced by microbial composition and gluten degrading *** conclusion that lactobacilli and Bifidobacterium *** be used as a probiotic supplement in CD patients is based on their shared possession of the most extensive peptidolytic and proteolytic activity thought to be engaged in the breakdown of gluten among all potential bacterial genera present in the gut *** children with CD autoimmunity,daily oral dose of *** HEAL9 and *** 8700:2 was found to modify the peripheral immune *** strains have demonstrated a beneficial effect on reducing pro-inflammatory cytokine TNF-production in CD children on gluten-free diets.

关键词： Celiac disease Gut microbiota probiotics probiotics supplementation Efficacy Immune system

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Effects of Bifidobacterium supplementation on intestinal microbiota composition and the immune response in healthy infants

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World Journal of Pediatrics 2016年第2期12卷 177-182页

作者： Bing-Bing Wu Yi Yang Xiu Xu Wei-Ping Wang Pediatrics Institute Key Laboratory of Neonatal DiseasesMinistry of HealthChildren's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China Department of Pediatric Healthcare Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China

Background:Intestinal microbiotas are thought to be the most important source of maturational stimuli to the development of the immune ***,few studies have focused on the development of T helper(Th)1 immune response and antibody response to vaccinations in healthy infants,especially in a large *** this randomized,double-blind control trial,we investigated the effects of Bifidobacterium longum BB536(BB536)supplementation on intestinal microbiota composition and the immune response in term ***:In total,300 healthy newborns were recruited,randomized and fed formula either supplemented with BB536 or with no *** samples were analyzed at months 2,4 and *** representative cytokine for Th1[interferon-γ(IFN-γ)]and Th2[interleukin-4(IL-4)]secretion cells were measured using enzyme-linked immunospot assay at 4 and 7 months of *** antibody response to vaccines was measured at months 7 and ***:A total of 264 infants completed the *** amount of bifidobacteria and the bifidobacteria/Enterobacteriaceae ratio(B/E)were signifi cantly higher in the BB536 supplementation group at months 2 and *** number of IFN-γsecretion cells and the ratio of IFN-γ/IL-4 secretion cells were increased in the BB536 supplementation group at 7 ***,the higher value of B/E in the early stages seems to be related to the increased Th1 *** difference was observed between groups in the antibody response after ***:BB536 has positive effects on establishing a healthy intestinal microbiota early in life,and it also plays an important role in improving the Th1 immune response.

关键词： intestinal microbiota probiotics supplementation term infants T helper 1/T helper 2 balance vaccination

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