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Linked brain connectivity patterns with psychopathological and cognitive phenotypes in drug-naive first-episode schizophrenia

引用

Psychoradiology 2022年第2期2卷 43-53页

作者： Hui Sun Wenjing Zhang Hengyi Cao Huaiqiang Sun Jing Dai Siyi Li Jiaxin Zeng XiaWei Biqiu Tang Qiyong Gong Su Lui Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan University610041 ChengduChina Center for Psychiatric Neuroscience Feinstein Institute for Medical Research11030 ManhassetNYUSA Division of Psychiatry Research Zucker Hillside Hospital11004 Glen OaksNYUSA Department of Psychoradiology Chengdu Mental Health Center610031 ChengduChina

Background Schizophrenia is considered to be a disorder of dysconnectivity characterized by abnormal functional integration between distinct brain *** brain connection abnormalities were found to be correlated with various clinical manifestations,but whether a common deficit in functional connectivity(FC)in relation to both clinical symptoms and cognitive impairments could present in first-episode patients who have never received any medication remains *** To find a core deficit in the brain connectome that is related to both psychopathological and cognitive *** A total of 75 patients with first-episode schizophrenia and 51 healthy control participants underwent scanning of the brain and clinical ratings of behaviors.A principal component analysis was performed on the clinical ratings of symptom and *** correlation analyses were conducted between the main psychopathological components and resting-state FC that were found abnormal in schizophrenia *** Using the principal component analysis,the first principal component(PC1)explained 37%of the total variance of seven clinical *** ratings of GAF and BACS contributed negatively to PC1,while those of PANSS,HAMD,and HAMA contributed *** FCs positively correlated with PC1 mainly included connections related to the insula,precuneus gyrus,and some frontal brain *** negatively correlated with PC1 mainly included connections between the left middle cingulate cortex and superior and middle occipital *** In conclusion,we found a linked pattern of FC associated with both psychopathological and cognitive manifestations in drug-na¨ıve first-episode schizophrenia characterized as the dysconnection related to the frontal and visual cortex,which may represent a core deficit of brain FC in patients with schizophrenia.

关键词： schizophrenia untreated functional connectome principal correlation analysis psychopathology

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