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The Experimental and Clinical Study on the Effect of Curcumin on cell Cycle Proteins and Regulating Proteins of Apoptosis in Acute Myelogenous Leukemia

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2002年第4期22卷 295-298页

作者：陈燕吴裕丹何静陈文娟 InstituteofHematology

To investigate whether the Bcl- 2 gene family is involved in m odulating mechanism of apoptosis and change of cell cycle protein induced by curcumin in acute myeloid leukemia HL - 6 0 cell line and primary acute m yelogenous leukem ic cells,the Bcl- 2 family member Mcl- 1,Bax and Bak and cell cycle proteins including P2 7kipl,P2 1wafl,cyclin D3and p Rbp- were selected and their ex- pression detected by SABC imm uno- histochem ical stain m *** attitude of sub- G1 peak in DNA histogram was determined by *** TU NEL positive cell percentage was identified by term inal deoxynucleotidyl transferase (Td T ) - m ediated Biotin d U NP end labeling *** was found that when HL - 6 0 cells were treated with 2 5μm ol/ L curcumin for 2 4 h,the expression level of Mcl- 1was down- regulated,but that of Bax and Bak up- regulated time- *** was significant difference in the expression level of Mcl- 1,Bax and Bak between the curcumin- treated groups and control group(Pcell cycle in prim aty acute m yelogenous leukemia at newly diagnosis,but could in- crease the peak of Sub- G1 (Pcells and AML *** can induce apoptosis of primary acute myelogenous leukemic cells and disturb cell cycle progression of HL - 6 0 *** m echanism appeared to be m ediated by perturbing G0 / G1 phases checkpoints which associated with up- regulation of P2 7kipl,P2 1wafl and p Rbp- expression,and down- regulation of cyclin D3.

关键词： curcum in Bcl- 2 gene family cell cycle protein HL - 6 0 cell prim ary leukemic cell

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