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prevention of Physiological Impairments from Whole Body Vibration by Conditioning with 4F ApoA-I Mimetic

Journal of Health Science 2014年第9期2卷 441-452页

作者： Ji-Geng Yan Lin-ling Zhang Michael Agresti Yuhui Yan Ammar Matloob Hani S. Matloub Kirkwood A. Pritchard Jr. Research Lab of Department of Plastic and Reconstructive Surgery Medical College of Wisconsin 8701 Watertown Plank RoadMilwaukee Wisconsin 53226 USA Research Lab of Department of Pediatric Surgery Children 's Hospital of Wisconsin 9000 West Wisconsin Avenue WauwatosaWisconsin 53226 USA

Is physical fatigue one of the major causes of motor vehicle accidents？ Our study results challenged this traditional belief, and indicated that motor vehicle induced whole body vibration （WBV） is the actual cause. In this study, rats were subjected to simulated WBV. After 2 weeks all rats were evaluated by multiple physiological tests. Results indicated that WBV for short periods impaired the animal＇s mental judgment capabilities as well as sensory and motor functions. The primary reason for this is that WBV caused vasoconstriction, which decreased the cerebral blood flow as shown by Doppler imaging. This reduction in blood flow impaired the animal＇s ability to run a maze. Nerve functions were affected as well. This was shown by a reduction in nerve conduction velocity （NCV）. An increase in tail flick and Von Frey withdrawal times showed sensory deficits. Grip strength was also reduced. 4F （human apolipoprotein A-I molecule mimetic） conditioning has shown preventive effects against WBV injury as indicated by the above functional tests. This animal model simulated the most common motor vehicle travel vibration and validated the biological cause and mechanism of physiological impairment from WBV, which can be translated into a practical application for motor vehicle accident prevention.

关键词： Vibration injury neural impairment 4F (human apolipoprotein A-I molecule mimetic) prevention of motor vehicleaccidents.

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