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Direct-writing Process and in vivo Evaluation of Prevascularized Composite Constructs for Muscle Tissue Engineering Application

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Journal of Bionic Engineering 2020年第3期17卷 457-468页

作者： Qin Lian Tingze Zhao Tian Jiao Yige Huyan Heng Gu Lin Gao State Key Laboratory for Manufacturing System Engineering Xi'an Jiaotong UniversityXi'an 710049China Health Science Center Xi'an Jiaotong Universityy Xi'an 710061China

Tissue engineered skeletal muscle is expected to treat muscle defects caused by trauma and ***,designing and manufacturing thick and complex tissue engineered skeletal muscle requires vascularization to ensure its internal cell viability and nutrient supply in *** this article,we developed a set of Direct-Writing(DW)bio-printing procedure to manufacture a prevascularized composite construct with Human Umbilical Vein Endothelial Cell(HUVEC)and C2C12 cells for muscle tissue engineering *** put the cells into the construct during the DW process to obtain the prevascularization and intend to promote its vascularization in vivo *** constructs with cells or without cells were implanted respectively into nude mice back for 3 weeks,after which the mice healthily live for all the time and all the implants are tightly bonded to the *** immunohistochemical analysis,CD31-positive blood vessels existed in the implanted samples with cells are more substantial than those without cells,but the implanted samples with HUVEC and C2C12 cells have much more number of small blood vessels distributing ***,the implants with cells,especially that with HUVEC and C2C12 cells,are able to get better fusion with the host skin and subcutaneous *** analysis demonstrates that our DW-based constructs have the potential to be getting to vascularize the tissue engineered muscle.

关键词： DW muscle tissue engineering in vivo experiment prevascularization

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Heterotopic bone formation in the musculus latissimus dorsi of sheep usingβ-tricalcium phosphate scaffolds:evaluation of different seeding techniques

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Regenerative Biomaterials 2018年第2期5卷 77-84页

作者： Simon Spalthoff Rudiger Zimmerer Jan Dittmann Horst Kokemuller Marco Tiede Laura Flohr Philippe Korn Nils-Claudius Gellrich Philipp Jehn Department of Oral and Maxillofacial Surgery Hannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany Department of Conservative Dentistry Periodontology and Preventive DentistryHannover Medical SchoolCarl-Neuberg-Str.1Hannover 30625Germany

Osseous reconstruction of large bone defects remains a challenge in oral and maxillofacial *** addition to autogenous bone grafts,which despite potential donor-site mobility still represent the gold standard in reconstructive surgery,many studies have investigated less invasive alternatives such as in vitro cultivation *** study compared different types of seeding techniques on pureβ-tricalcium phosphate scaffolds in terms of bone formation and ceramic resorption in *** scaffolds loaded with autologous cancellous bone,venous blood,bone marrow aspirate concentrate or extracorporeal in vitro cultivated bone marrow stromal cells were cultured in sheep on a perforator vessel of the musculus latissimus dorsi over a 6-month *** and histomorphometric analyses revealed that scaffolds loaded with cancellous bone were superior at promoting heterotopic bone formation and ceramic degradation,with autogenous bone and bone marrow aspirate concentrate inducing in vivo formation of vital bone *** results confirm that autologous bone constitutes the preferred source of osteoinductive and osteogenic material that can reliably induce heterotopic bone formation in vivo.

关键词： heterotopic bone formation β-tricalcium phosphate bone marrow stromal cells bone marrow aspirate concentrate prevascularization ceramic degradation

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