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preorganization boosts the artificial esterase activity of a self-assembling peptide

Science China Chemistry 2021年第9期64卷 1554-1559页

作者： Yaoxia Chen Wenwen Zhang Yinghao Ding Chunhui Liang Yang Shi Zhi-Wen Hu Ling Wang Zhimou Yang State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy Nankai UniversityTianjin300071China Key Laboratory of Bioactive Materials Ministry of EducationState Key Laboratory of Medicinal Chemical BiologyCollege of Life Sciencesand Collaborative Innovation Center of Chemical Science and Engineering(Tianjin)National Institute for Advanced MaterialsNankai UniversityTianjin300071China Department of Cell Biology School of Basic Medical ScienceCheeloo College of MedicineShandong UniversityJinan250100China

The creation of artificial enzymes to mimic natural enzymes remains a great challenge owing to the complexity of the structural arrangement of the essential amino acids in catalytic *** this study,we used the phosphatase-based enzyme-instructed self-assembly(EISA)to supervise artificial esterases'final structures and catalytic *** reported that peptide precursors containing different phosphorylation sites could preorganize into alternated nanostructures and undergo dephosphorylation in the presence of alkaline phosphatase(ALP)with variation in kinetic and thermodynamic *** identical self-assembly compositions were formed after dephosphorylation,precursors with more enhanced preorganized states tended to better promote ALP dephosphorylation,facilitate further self-assembly,and strengthen the catalytic activities of the final *** envisioned that our strategy would be useful for further construction and manipulation of various artificial enzymes with superior catalytic activities.

关键词： enzyme-instructed self-assembly preorganization artificial esterase catalytic activities peptide folding

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Macrocyclic versus acyclic preorganization in organoplatinum(Ⅱ)-based host-guest complexes

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Chinese Chemical Letters 2019年第11期30卷 1927-1930页

作者： Xiaolong Zhang Yifei Han Guangyao Liu Feng Wang CAS Key Laboratory of Soft Matter Chemistry iChEM (Collaborative Innovation Center of Chemistry for Energy Materials)Department of Polymer Science and EngineeringUniversity of Science and Technology of China

Two host-guest systems have been constructed,by employing structurally similar terpyridine platinum(II)macrocycle and molecular tweezer as the synthetic *** macrocycle/guest complex displays low-energy emission signal,reinforced non-covalent binding affinity,and enhanced photosensitization capability than those of the molecular tweezer/guest *** discrepancy between macrocyclic and acyclic preorganization modes originates from the different numbers of Pt(II)Pt(II)metal-metal bonds in host-guest complexation structures.

关键词： Supramolecular chemistry preorganization Host-guest recognition Metal-metal interactions Photosensitization

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