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Barrier Effect of Placenta Membrane of pregnant rat on Mixed Rare Earth Changle

Journal of Rare Earths 2003年第3期21卷 391-394页

作者：周莉陈辉黄可欣李树蕾聂毓秀 Department of Histology and Embryology School of Basic Medical Sciences of Jilin University A trainer attending advanced studies from Jilin Health School in China

To assess the potential health risks of mixed rare earths Changle for human embryo, whether it crosses placenta membrane or placenta barrier should be determined. In order to arrive at the aim placenta tissue was observed after contamination with optical and electron microscope to show distribution and destiny of mixed rare earth Changle in placenta tissue. Meanwhile the amount of rare earths in serum of pregnant rat, amniotic fluid and extract of embryo tissue were measured by using Inductively Coupled Plasma Mass Spectrometer (ICP MS). The rats were administered to 0 3, 2, 5 and 20 mg·kg -1 mixed rare earths Changle every day, respectively by oral from the 6th to 18th day after pregnancy. The results show that many particles are found in syncytiotrophoblast around capillaries of placental villi in contaminated groups under light microscope, and there are more particles following increased dose. It also was observed that some dense bodies with the envelope in placenta membrane and to difference extent damages the mitochondria crista within syncytiotrophoblast cytoplasm in contaminated groups under transmission electron microscope (TEM). Results of ICP MS assay indicate that the level of Ce increases with contamination dose in the serum of pregnant rats, and the level of total rare earth element remarkably rises in amniotic fluid and serum of pregnant rats for 20 mg·kg -1 group as compared with the control without change for the other groups.

关键词： cyotobiology mixed rare earth Changle placenta membrane ICP MS assay pregnant rat rare earths

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Studies on Nutritional Effects of Traditional Chinese Tonics with Nutrients Fortification on pregnant Women and pregnant rats

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Chinese Journal of Integrative Medicine 1997年第3期3卷 174-178页

作者：凌诚德华金中李菊花张振钧丁以斌

Objective: To explore the nutritional and health promoting effects of nutrient mixture (traditional Chinese tonics ＋ nutrient fortification). Methods: (1) One hundred and three primigravid women were divided randomly into the test group and the control group treated with nutrient mixture and vitamins respectively and the effects of treatment were observed. (2) Effects of nutrient mixture were also observed in pregnant rats. Results: (1) Clinical study showed the serum levels of iron, zinc, hemoglobin of the test group were allraised after treatment, and these parameters and the concentration of iron in umbilical cord blood as well as the weight of the new-born baby of the test group were higher than those of the control group (P ＜0. 05 or P＜0. 01). (2) Results of the experimental study showed that the food utilization rate, hemoglobin level, fetal growth and developing parameters of the test group were all higher than those of the control group significantly (P ＜0. 05 or P＜ 0. 01 ). Conclusion: The nutrient mixture has a good nutritional and health promoting effect on pregnancy.

关键词： nutrition with traditional Chinese tonic nutrient pregnant women pregnant rat nutritional and health promoting effect

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Ototoxicity of styrene

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Journal of Otology 2011年第2期6卷 1-9页

作者： Donald Henderson Center for Hearing and Deafness Center for Hearing and Deafness The State University of New York at Buffalo BuffaloNY 14214U.S.A

Styrene is extensively used in industry,but its ototoxicity,in particular in the pregnant female and the offspring,is still not well *** the current study,young adult male rats and pregnant female rats were exposed to styrene by gavage at different *** young adult male rats received a total of 12g/kg styrene within different periods (800 mg/kg/day for 5 days/week for 3 weeks,400 mg/kg/day for 5 days/week for 6 weeks,200 mg/kg/day for 5 days/week for 12 weeks,and 100 mg/kg/day for 5 days/week for 24 weeks) and the pregnant female rats received styrene at a dose of 400 mg/kg/day for 5 days/week for 6 weeks starting from the gestation *** loss and hair cell loss were assessed 5 days after the styrene treatment in the young adult male rats and in the mother *** cochlear impairments in the rat pups were examined 2 months after their *** styrene exposure caused hearing loss and hair cell loss starting from the mid-frequency region in the third row of outer hair cells (OHCs) and the impairments appeared to be related to the dosing level in each single ***,the styrene exposure to the pregnant rats interfered with auditory functional development of their fetus,leading to a deficit of cochlear amplification,although the OHCs appeared to develop *** results indicate that a short-term high-level styrene exposure may be more ototoxic than a long-term low-level exposure for a similar total styrene dose and the styrene in the pregnant woman’s body may interfere with auditory development of their fetus.

关键词： Styrene ototoxicity pregnant rat Exposure during gestation Exposure during lactation

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