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Safety of Mifepristone in Medical Abortion in Hyperthyroidism pregnant mice

Reproductive and Developmental Medicine 2019年第1期3卷 30-35页

作者： Yun-Hui Tang Xiao-Ying Yao Department of Family Planning Obstetrics and Gynecology Hospital of Fudan UniversityShanghai 200011China

Objective:To study the safety of mifepristone on thyroid hormone level by using hyperthyroidism pregnant model in mouse to simulate the process of medical abortion and observe the changes of thyroid hormone during ***:A total of 60 female Institute of Cancer Research(ICR)mice aged 6-8 weeks were divided into control group,control group with 0 mgRU486 group(control-0 mgRU486),control group with 2 mgRU486 group(control-2 mgRU486),hyperthyroid pregnant mice with 0 mgRU486 group(hyper-0 mgRU486),hyperthyroid pregnant mice with 2 mgRU486 group(hyper-2 mgRU486),and hyperthyroid pregnant mice with 20 mgRU486 group(hyper-20 mgRU486).In the hyperthyroidism groups,L-thyroxine sodium was intraperitoneally injected every day at 30μg·kg^(−1)·day^(−1) until the end of the *** the 7^(th) day of the experiment,free triiodothyronine(FT3),free tetraiodothyroxine(FT4),thyroxine(TT4),and thyroid-stimulating hormone(TSH)levels were *** mice in the control groups and those in the experimental groups were paired with the male mice(2:1)on the 10^(th) day of the experiment,and the caging was *** the 8^(th) day of pregnancy(day 8),pregnant mice were subcutaneously injected with mifepristone in different doses and were sacrificed 6 h *** rate and the number of embryos were *** tissues were observed by hematoxylin and eosin(HE)*** TSH level was determined by ***:Six hours after injection with mifepristone,serum FT3,FT4,and TT4 levels of pregnant mice were all *** increased levels in the mice under hyperthyroidism were different from those in the control groups(Pmice under hyperthyroidism was significantly i

关键词： Hyperthyroidism Medical Abortion Mifepristone pregnant mice

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A protective role of resveratrol against the effects of immobilization stress in corpora lutea of mice in early pregnancy

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Journal of Integrative Agriculture 2020年第7期19卷 1857-1866页

作者： Saif ULLAH Sheeraz MUSTAFA Wael ENNAB Muhammad JAN Muhammad SHAFIQ Ngekure MXKAVITA LU Zeng-peng MAO Da-gan SHI Fang-xiong College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095P.R.China

In the present study,we aimed to investigate a protective role for resveratrol against the effects of immobilization stress on corpora lutea(CL)of mice in early pregnancy.A total of 45 early-pregnant mice were divided into no immobilization stress(NIS)group,immobilization stress(IS)group,and immobilization and resveratrol treatment(IS+RES)group(n=15).mice were immobilized in plastic tubes(50 mL)for 3 h per day during day 1 to 7 of *** the IS+RES group,5 mg kg-'d-1 of resveratrol was administered just prior to application of *** analyzed apoptotic activity in CL by Western botting analysis(WB),transmission electron microscopy(TEM),and immunohistochemistry(IHC).Serum progesterone levels were examined with radioimmunoassay(RIA).IHC results showed that the intensity of positive staining for Bax was increased,and for BcI-2 was decreased in CL after IS,while resveratrol treatment reversed the positive staining for Bax and *** revealed that immobilization stress up-regulated the expression of Bax and caspase-9,and down-regulated Bcl-2 expression,while resveratrol treatment attenuated the effects of immobilization stress on the expression of Bax,Bcl-2 and *** to our TEM results,apoptosis as defined by chromatin condensation was found in CL after immobilization stress,while resveratrol inhibited the *** also demonstrated that immobilization stress decreased progesterone concentrations and ovarian expression of StAR,while resveratrol restored the concentrations of progesterone and expression of StAR back to *** results indicated that immobilization stress induced luteal regression while resveratrol inhibited luteal regression,suggesting that resveratrol plays a protective role on corpora lutea of mice during early pregnancy.

关键词： immobilization stress apoptosis corpora lutea resveratrol pregnant mice

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